HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: KS6B2 (Q9UBS0)
Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta)
Gene: RPS6KB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25324306, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 482
+	Hs
		682173 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT2_HUMAN (26-391): 9.02e-155: 450: 41.24
+	Hs
		1035058 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT3_HUMAN (6-391): 7.6e-154: 447: 39.85
+	Hs
		681830 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT1_HUMAN (5-391): 6.01e-153: 445: 39.19
+	Hs
		981051 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KPCT_HUMAN (8-399): 2.54e-145: 433: 34.67
+	Hs
		568651 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KAPCA_HUMAN (31-387): 1.3e-144: 419: 34.17
+	Hs
		969070 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		KPCE_HUMAN (2-395): 2.02e-145: 435: 34.23
+	Hs
		117002 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		SGK1_HUMAN (55-393): 4e-100: 308: 47.03
+	Hs
		272862 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KS6A4_HUMAN (39-450): 2.95e-78: 261: 24.07
+	Hs
		1053243 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		KS6B2_HUMAN (1-482): 0: 531: 100.00
+	Rn
		193486 STIP1_RAT (265-457): 1.25e-22: 102: 18.14		AKT3_RAT (6-391): 7.74e-152: 442: 39.59
+	Hs
		568664 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		KAPCA_HUMAN (31-387): 1.3e-144: 419: 34.17
+	Hs
		118776 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		SGK3_HUMAN (46-393): 3.33e-94: 295: 45.00
+	Dm
		1179507 Q7K3D4_DROME (3-148): 5.36e-22: 99.5: 23.31		Q9VR61_DROME (18-403): 5.76e-91: 297: 24.44