Protein: UB2G2
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)

Gene: UB2G2, UBE2G2
Organism: Homo sapiens
Interactions: 96
UniProt ID: P60604

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005783 - endoplasmic reticulum
GO:0005811 - lipid droplet

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

952481

AMFR
E3 ubiquitin-protein ligase AMFR

18

20

Small-scale

0.989

High

241245

PRKN
E3 ubiquitin-protein ligase parkin

6

20

Small-scale

0.942

High

647520

UBA1
Ubiquitin-like modifier-activating enzyme 1

6

20

Small-scale

0.940

High

507746

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

20

Small-scale

0.925

High

952425

UB2G2
Ubiquitin-conjugating enzyme E2 G2

4

16

Small-scale

0.916

High

952430

RBX1
E3 ubiquitin-protein ligase RBX1

3

20

Small-scale

0.845

High

952459

OTUB1
Ubiquitin thioesterase OTUB1

2

6

High-throughput

0.737

High

952488

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

9

0

Small-scale

0.720

High

244454

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

7

High-throughput

0.698

High

279036

TRIM3
Tripartite motif-containing protein 3

1

20

High-throughput

0.698

High

952431

MDM2
E3 ubiquitin-protein ligase Mdm2

1

13

High-throughput

0.698

High

952440

RN111
E3 ubiquitin-protein ligase Arkadia

1

20

High-throughput

0.698

High

952444

RN168
E3 ubiquitin-protein ligase RNF168

1

4

High-throughput

0.698

High

952452

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

20

High-throughput

0.698

High

952453

RFFL
E3 ubiquitin-protein ligase rififylin

1

20

High-throughput

0.698

High

952465

RNF26
E3 ubiquitin-protein ligase RNF26

1

20

High-throughput

0.698

High

952475

RN146
E3 ubiquitin-protein ligase RNF146

1

3

High-throughput

0.698

High

724380

COR1A
Coronin-1A

1

5

High-throughput

0.665

High

48348

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

20

Small-scale

0.647

High

623216

RO52
E3 ubiquitin-protein ligase TRIM21

1

20

Small-scale

0.647

High

952463

RNF5
E3 ubiquitin-protein ligase RNF5

1

20

Small-scale

0.647

High

952472

RN167
E3 ubiquitin-protein ligase RNF167

1

20

Small-scale

0.647

High

952462

RN157
E3 ubiquitin ligase RNF157

1

7

High-throughput

0.625

High

952454

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

20

Small-scale

0.621

High

543119

UBL4A
Ubiquitin-like protein 4A

1

20

High-throughput

0.618

High

952432

CUL3
Cullin-3

1

15

High-throughput

0.618

High

952442

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.618

High

952448

RN149
E3 ubiquitin-protein ligase RNF149

1

20

High-throughput

0.618

High

952451

RN139
E3 ubiquitin-protein ligase RNF139

1

20

Small-scale

0.618

High

952479

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

952480

FBW1B
F-box/WD repeat-containing protein 11

1

20

High-throughput

0.618

High

952461

BIRC8
Baculoviral IAP repeat-containing protein 8

1

20

High-throughput

0.555

High

952466

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

Small-scale

0.553

High

952486

HBS1L
HBS1-like protein

1

2

High-throughput

0.541

High

698542

CALX
Calnexin

1

4

High-throughput

0.536

High

952455

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

952439

Q6PIA0
Baculoviral IAP repeat-containing 8

1

20

High-throughput

0.528

High

320550

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

0

High-throughput

0.518

High

784855

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.518

High

952464

VAMP8
Vesicle-associated membrane protein 8

1

0

High-throughput

0.518

High

952469

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.518

High

952477

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

2

High-throughput

0.515

High

952487

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.515

High

699672

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.515

High

952427

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.513

High

952443

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

952458

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.513

High

952468

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

246284

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

19

Small-scale

0.501

High

952437

RC3H1
Roquin-1

1

7

Small-scale

0.501

High

952474

RC3H2
Roquin-2

1

8

Small-scale

0.501

High

936537

AF17
Protein AF-17

1

1

High-throughput

0.494

High

952445

ARL14
ADP-ribosylation factor-like protein 14

1

6

High-throughput

0.494

High

952450

CNNM3
Metal transporter CNNM3

1

1

High-throughput

0.494

High

952457

TRI43
Tripartite motif-containing protein 43

1

20

High-throughput

0.494

High

952484

KDM2A
Lysine-specific demethylase 2A

1

8

High-throughput

0.494

High

952438

ECM29
Proteasome adapter and scaffold protein ECM29

1

5

Small-scale

0.481

High

363065

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

567327

TCTP
Translationally-controlled tumor protein

1

5

High-throughput

0.479

High

952426

RAC3
Ras-related C3 botulinum toxin substrate 3

1

5

High-throughput

0.479

High

952428

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

952429

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

952434

DUS6
Dual specificity protein phosphatase 6

1

1

High-throughput

0.479

High

952478

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

774250

BASI
Basigin

1

2

High-throughput

0.470

High

133736

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

293455

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

347609

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

947094

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

952460

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

952473

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

952476

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

303222

S22A5
Organic cation/carnitine transporter 2

1

1

High-throughput

0.445

High

838972

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.445

High

952485

S27A5
Long-chain fatty acid transport protein 5

1

2

High-throughput

0.445

High

766365

PHB1
Prohibitin 1

1

1

High-throughput

0.437

High

952436

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

2

High-throughput

0.437

High

952470

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.437

High

952471

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

211125

CTR4
Cationic amino acid transporter 4

1

4

High-throughput

0.407

High

870218

S6A12
Sodium- and chloride-dependent betaine transporter

1

1

High-throughput

0.407

High

870349

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.407

High

912648

CTR2
Cationic amino acid transporter 2

1

5

High-throughput

0.407

High

952435

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

3

High-throughput

0.407

High

952446

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.407

High

952447

MFSD9
Major facilitator superfamily domain-containing protein 9

1

3

High-throughput

0.407

High

952449

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

209761

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.282

High

952456

TM45B
Transmembrane protein 45B

1

0

High-throughput

0.282

High

952433

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.249

Low

952467

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

952482

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

256017

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

952441

NIPA1
Magnesium transporter NIPA1

1

0

High-throughput

0.232

Low

952483

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025