HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: DBLOH (Q9NR28)
Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]
Gene: DIABLO

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 27476169, 28514442, 10929712, 33961781, 35941108, 16282325, 20957035, 12218061, 25246529, 12865429, 30359437, 35027744, 14960576, 12525502, 19506082, 19153467, 25065467, 11606597
Identification Methods affinity chromatography technology, pull down, enzymatic study, x-ray crystallography, unspecified method, anti tag coimmunoprecipitation, coimmunoprecipitation, surface plasmon resonance
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~Smac_DIABLO
Common GO terms GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0009898 - cytoplasmic side of plasma membrane
GO:0035631 - CD40 receptor complex
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 618
Hs

1 239
+ Mm
+ Mm
+ Hs
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+ Hs
+ Hs
+ Mm
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+ Rn
+ Hs

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Last updated: 15 Jul 2024