HitPredict

Interactor 1: MTMR2 (Q13614)
Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
Gene: MTMR2

Interactor 2: MTMRC (Q9C0I1)
Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein)
Gene: MTMR12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	27880917, 28675297, 25659891, 35271311, 12847286
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	GRAM~Myotub-related, Myotub-related~Myotub-related
Common GO terms	GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0046856 - phosphatidylinositol dephosphorylation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 643 Hs			1 747
+	Hs
		1036533 MTM1_HUMAN (42-641): 0: 805: 64.78		MTMRC_HUMAN (13-747): 0: 930: 100.00
+	Hs
		1040925 MTMR2_HUMAN (1-643): 0: 934: 100.00		MTMRA_HUMAN (14-730): 0: 788: 35.06
+	Hs
		1036536 MTM1_HUMAN (42-641): 0: 805: 64.78		MTMRA_HUMAN (14-730): 0: 788: 35.06
+	Hs
		1040903 MTMR2_HUMAN (1-643): 0: 934: 100.00		MTMR2_HUMAN (41-561): 0: 559: 24.50
+	Hs
		1040859 MTMR2_HUMAN (1-643): 0: 934: 100.00		MTMR1_HUMAN (39-561): 0: 552: 22.74
+	Hs
		59913 MTMR2_HUMAN (1-643): 0: 934: 100.00		MTMRB_HUMAN (46-706): 0: 544: 27.43
+	Hs
		1036512 MTMR2_HUMAN (1-643): 0: 934: 100.00		MTM1_HUMAN (33-561): 0: 542: 21.65
+	Hs
		1040916 MTMR2_HUMAN (1-643): 0: 934: 100.00		MTMR9_HUMAN (66-553): 7.7e-144: 434: 21.01
+	Hs
		59912 MTM1_HUMAN (42-641): 0: 805: 64.78		MTMRB_HUMAN (46-706): 0: 544: 27.43
+	Hs
		1036511 MTM1_HUMAN (42-641): 0: 805: 64.78		MTM1_HUMAN (33-561): 0: 542: 21.65
+	Hs
		1040880 MTMR1_HUMAN (11-643): 0: 879: 69.72		MTMR9_HUMAN (66-553): 7.7e-144: 434: 21.01
+	Hs
		1289611 MTMR8_HUMAN (88-635): 0: 672: 37.88		MTMR8_HUMAN (59-608): 1.02e-164: 493: 21.58
+	Hs
		1289613 MTMR8_HUMAN (88-635): 0: 672: 37.88		MTMR9_HUMAN (66-553): 7.7e-144: 434: 21.01
+	Hs
		309479 MTMR2_HUMAN (1-643): 0: 934: 100.00		MTMR5_HUMAN (209-280): 1.4e-14: 80.2: 18.07
+	Hs
		1040909 MTMR2_HUMAN (1-643): 0: 934: 100.00		MTMRD_HUMAN (209-280): 3.4e-11: 69: 18.07
+	Hs
		309478 MTMR1_HUMAN (11-643): 0: 879: 69.72		MTMR5_HUMAN (209-280): 1.4e-14: 80.2: 18.07
+	Hs
		1040871 MTMR1_HUMAN (11-643): 0: 879: 69.72		MTMRD_HUMAN (209-280): 3.4e-11: 69: 18.07
+	Dm
		1181856 Q9VMI9_DROME (79-634): 0: 739: 59.83		Q7KSP6_DROME (39-326): 2.7e-49: 189: 14.21