HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KBTB2 (Q8IY47)
Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1)
Gene: KBTBD2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	27708159, 28514442, 33961781, 34878901, 35563538, 21145461, 34591642
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0010467 - gene expression GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 623
+	Hs
		1042149 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB7_HUMAN (3-615): 1.71e-158: 472: 24.29
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (3-588): 4.25e-139: 420: 21.45
+	Hs
		1041715 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH22_HUMAN (3-607): 1.88e-130: 398: 20.29
+	Hs
		1042083 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB8_HUMAN (10-592): 7.74e-124: 380: 32.83
+	Hs
		1041942 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB6_HUMAN (3-592): 8.1e-62: 219: 26.55
+	Hs
		238083 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH41_HUMAN (6-521): 8.06e-54: 195: 26.64
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (26-561): 9.93e-48: 178: 25.48
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (382-617): 5.3e-45: 170: 16.80
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (18-476): 5.18e-43: 165: 24.32
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (363-617): 5.54e-41: 160: 15.97
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (363-617): 1.34e-40: 158: 15.59
+	Hs
		1042027 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH36_HUMAN (364-618): 2.83e-34: 140: 15.58
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (429-620): 1.14e-30: 129: 13.07
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (203-428): 2.72e-29: 125: 17.03
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (431-617): 4.2e-27: 118: 15.39
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (450-617): 4.48e-18: 90: 16.28
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (359-619): 1.65e-16: 84.9: 11.72
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (437-616): 9.1e-12: 69.9: 13.04
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (515-617): 5.14e-10: 64.5: 13.76
+	Hs
		1042057 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH23_HUMAN (246-380): 5.3e-10: 64.1: 13.33