HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: ABTB1 (Q969K4)
Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein)
Gene: ABTB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25416956, 21145461, 31515488
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 478
+	Hs
		1042047 CUL3_HUMAN (1-768): 0: 951: 100.00		ABTB2_HUMAN (6-446): 2.5e-61: 218: 17.75
+	Hs
		64280 CUL3_HUMAN (1-768): 0: 951: 100.00		ABTB3_HUMAN (6-445): 1.9e-60: 215: 18.25
+	Hs
		1042057 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH23_HUMAN (271-477): 2.18e-50: 181: 22.12
+	Hs
		1041715 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH22_HUMAN (273-474): 2.14e-43: 163: 21.95
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (97-374): 9.38e-37: 144: 13.93
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (91-285): 1.61e-35: 141: 17.95
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (63-285): 3.09e-35: 140: 12.28
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (105-263): 1.01e-34: 139: 18.87
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (105-263): 1.43e-34: 138: 18.87
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (105-285): 8.7e-34: 136: 16.02
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (80-271): 2.03e-33: 135: 15.10
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (105-285): 3.6e-33: 134: 13.81
+	Hs
		1042026 CUL3_HUMAN (1-768): 0: 951: 100.00		Q8N4I8_HUMAN (87-285): 5.27e-35: 134: 13.57
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (52-361): 5.88e-33: 133: 16.29
+	Hs
		1041991 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB2_HUMAN (100-270): 2.57e-30: 126: 17.54
+	Hs
		152489 CUL3_HUMAN (1-768): 0: 951: 100.00		ENC1_HUMAN (96-270): 1.04e-28: 121: 17.32
+	Hs
		1042036 CUL3_HUMAN (1-768): 0: 951: 100.00		LZTR1_HUMAN (245-445): 2.33e-22: 102: 13.04
+	Hs
		1041780 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD8_HUMAN (86-442): 2.9e-18: 90.5: 16.67
+	Hs
		214258 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOP_HUMAN (101-262): 1.68e-10: 64.4: 17.90
+	Hs
		1041805 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOPL_HUMAN (105-212): 2.1e-09: 61.3: 26.61