HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: UBP25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
Gene: USP25

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	28619731, 35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1055
+	Hs
		1043635 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Hs
		1041490 CUL2_HUMAN (30-768): 0: 672: 26.17		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Hs
		1041879 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP34_HUMAN (132-425): 1.83e-73: 269: 22.11
+	Hs
		1042213 CUL3_HUMAN (1-768): 0: 951: 100.00		USP9X_HUMAN (142-459): 2.23e-67: 250: 20.22
+	Hs
		1042856 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP24_HUMAN (158-405): 3.95e-35: 148: 21.40
+	Hs
		1043072 CUL4A_HUMAN (10-768): 0: 791: 38.32		UBP34_HUMAN (132-425): 1.83e-73: 269: 22.11
+	Hs
		1042855 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP22_HUMAN (477-661): 1.12e-19: 96.2: 17.30
+	Hs
		1042214 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		1043144 CUL4A_HUMAN (10-768): 0: 791: 38.32		USP9X_HUMAN (142-459): 2.23e-67: 250: 20.22
+	Hs
		1043436 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBP48_HUMAN (157-406): 1.37e-66: 245: 25.86
+	Hs
		1043145 CUL4A_HUMAN (10-768): 0: 791: 38.32		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		1043497 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		1041131 CUL1_HUMAN (18-768): 0: 707: 30.57		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78