Protein: AGRE5
Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta]

Gene: AGRE5, ADGRE5
Organism: Homo sapiens
Interactions: 176
UniProt ID: P48960

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

878109

AGRE2
Adhesion G protein-coupled receptor E2

2

15

High-throughput

0.789

High

835256

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

6

High-throughput

0.691

High

878068

LPAR1
Lysophosphatidic acid receptor 1

4

12

High-throughput

0.691

High

349394

TSN15
Tetraspanin-15

3

14

High-throughput

0.662

High

749316

TNFL8
Tumor necrosis factor ligand superfamily member 8

3

3

High-throughput

0.662

High

878106

GPC5B
G-protein coupled receptor family C group 5 member B

3

2

High-throughput

0.662

High

467005

DAF
Complement decay-accelerating factor

1

1

Small-scale

0.647

High

878065

TM171
Transmembrane protein 171

3

0

High-throughput

0.638

High

878037

GL8D1
Glycosyltransferase 8 domain-containing protein 1

3

0

High-throughput

0.634

High

179842

BET1
BET1 homolog

2

1

High-throughput

0.628

High

226419

SNG2
Synaptogyrin-2

2

3

High-throughput

0.628

High

548319

CP2C9
Cytochrome P450 2C9

2

2

High-throughput

0.628

High

789876

FDFT
Squalene synthase

2

1

High-throughput

0.628

High

878034

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

2

7

High-throughput

0.628

High

878047

ZDH21
Palmitoyltransferase ZDHHC21

2

6

High-throughput

0.628

High

878082

S29A1
Equilibrative nucleoside transporter 1

2

2

High-throughput

0.628

High

878088

YIPF3
Protein YIPF3

2

3

High-throughput

0.628

High

878101

SERC1
Serine incorporator 1

2

2

High-throughput

0.628

High

878107

B4GT7
Beta-1,4-galactosyltransferase 7

2

1

High-throughput

0.628

High

878110

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

2

6

High-throughput

0.628

High

878112

VDAC3
Non-selective voltage-gated ion channel VDAC3

2

1

High-throughput

0.628

High

878117

ALG6
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

2

1

High-throughput

0.628

High

878118

MTCH2
Mitochondrial carrier homolog 2

2

4

High-throughput

0.628

High

62919

POTEF
POTE ankyrin domain family member F

2

0

High-throughput

0.602

High

250925

TPST1
Protein-tyrosine sulfotransferase 1

2

0

High-throughput

0.602

High

878022

NNTM
NAD(P) transhydrogenase, mitochondrial

2

0

High-throughput

0.602

High

878035

TM63B
Mechanosensitive cation channel TMEM63B

2

0

High-throughput

0.602

High

878044

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

0

High-throughput

0.602

High

878057

LEMD2
LEM domain-containing protein 2

2

0

High-throughput

0.602

High

878099

JPH1
Junctophilin-1

2

0

High-throughput

0.602

High

878114

GOT1B
Vesicle transport protein GOT1B

2

0

High-throughput

0.602

High

565579

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

2

3

High-throughput

0.601

High

844989

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.601

High

878026

S39AE
Metal cation symporter ZIP14

2

13

High-throughput

0.601

High

878060

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

2

7

High-throughput

0.601

High

878078

OPALI
Opalin

2

0

High-throughput

0.576

High

397728

NU5M
NADH-ubiquinone oxidoreductase chain 5

2

2

High-throughput

0.574

High

878061

MFSD8
Major facilitator superfamily domain-containing protein 8

2

4

High-throughput

0.574

High

878073

YIPF6
Protein YIPF6

2

2

High-throughput

0.574

High

878095

IPPK
Inositol-pentakisphosphate 2-kinase

2

1

High-throughput

0.574

High

878102

ZDH18
Palmitoyltransferase ZDHHC18

2

4

High-throughput

0.574

High

878045

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.553

High

132580

UPK1A
Uroplakin-1a

1

16

High-throughput

0.536

High

139194

UPK2
Uroplakin-2

1

6

High-throughput

0.536

High

141824

ACKR2
Atypical chemokine receptor 2

1

10

High-throughput

0.536

High

165545

SCAM3
Secretory carrier-associated membrane protein 3

1

2

High-throughput

0.536

High

165916

FFAR1
Free fatty acid receptor 1

1

8

High-throughput

0.536

High

184409

SURF4
Surfeit locus protein 4

1

2

High-throughput

0.536

High

186415

TM9S1
Transmembrane 9 superfamily member 1

1

2

High-throughput

0.536

High

219286

B4GA1
Beta-1,4-glucuronyltransferase 1

1

2

High-throughput

0.536

High

226314

SNG1
Synaptogyrin-1

1

3

High-throughput

0.536

High

270438

FZD7
Frizzled-7

1

6

High-throughput

0.536

High

351879

S1PR4
Sphingosine 1-phosphate receptor 4

1

14

High-throughput

0.536

High

373832

RASN
GTPase NRas

1

9

High-throughput

0.536

High

419970

B3A2
Anion exchange protein 2

1

4

High-throughput

0.536

High

640374

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

11

High-throughput

0.536

High

698481

CALX
Calnexin

1

8

High-throughput

0.536

High

723219

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

5

High-throughput

0.536

High

723675

NTR1
Neurotensin receptor type 1

1

5

High-throughput

0.536

High

771759

SCN4A
Sodium channel protein type 4 subunit alpha

1

11

High-throughput

0.536

High

833810

P2RY2
P2Y purinoceptor 2

1

12

High-throughput

0.536

High

852696

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

1

High-throughput

0.536

High

868291

P2RY1
P2Y purinoceptor 1

1

10

High-throughput

0.536

High

878005

PSN1
Presenilin-1

1

1

High-throughput

0.536

High

878015

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.536

High

878019

AT2C1
Calcium-transporting ATPase type 2C member 1

1

1

High-throughput

0.536

High

878023

TMED1
Transmembrane emp24 domain-containing protein 1

1

4

High-throughput

0.536

High

878029

OCLN
Occludin

1

1

High-throughput

0.536

High

878031

ZACN
Ligand-gated cation channel ZACN

1

7

High-throughput

0.536

High

878036

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.536

High

878043

CERS6
Ceramide synthase 6

1

4

High-throughput

0.536

High

878046

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

2

High-throughput

0.536

High

878049

K2013
Uncharacterized protein KIAA2013

1

1

High-throughput

0.536

High

878050

AN13A
Ankyrin repeat domain-containing protein 13A

1

1

High-throughput

0.536

High

878055

TM87A
Transmembrane protein 87A

1

3

High-throughput

0.536

High

878062

GOGA5
Golgin subfamily A member 5

1

4

High-throughput

0.536

High

878063

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

7

High-throughput

0.536

High

878070

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

878074

CLP1L
Lipid scramblase CLPTM1L

1

1

High-throughput

0.536

High

878076

SGCZ
Zeta-sarcoglycan

1

1

High-throughput

0.536

High

878079

SERC2
Serine incorporator 2

1

2

High-throughput

0.536

High

878080

HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

1

1

High-throughput

0.536

High

878084

PTSS2
Phosphatidylserine synthase 2

1

1

High-throughput

0.536

High

878086

FUT8
Alpha-(1,6)-fucosyltransferase

1

1

High-throughput

0.536

High

878087

TTYH3
Protein tweety homolog 3

1

3

High-throughput

0.536

High

878091

TTYH1
Protein tweety homolog 1

1

3

High-throughput

0.536

High

878097

GPR35
G-protein coupled receptor 35

1

12

High-throughput

0.536

High

878098

AT131
Endoplasmic reticulum transmembrane helix translocase

1

5

High-throughput

0.536

High

878100

GPC5C
G-protein coupled receptor family C group 5 member C

1

2

High-throughput

0.536

High

878103

T161A
Transmembrane protein 161A

1

1

High-throughput

0.536

High

878104

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

1

High-throughput

0.536

High

878108

CLC2D
C-type lectin domain family 2 member D

1

10

High-throughput

0.536

High

506576

GPHRB
Golgi pH regulator B

2

6

High-throughput

0.533

High

230770

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

316491

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.513

High

483891

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.513

High

878020

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

0

High-throughput

0.513

High

878028

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

878053

TM252
Transmembrane protein 252

1

0

High-throughput

0.513

High

878111

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.513

High

878115

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.513

High

878116

BACE2
Beta-secretase 2

1

0

High-throughput

0.513

High

85353

GPHRA
Golgi pH regulator A

2

6

High-throughput

0.504

High

189128

IPO8
Importin-8

1

2

High-throughput

0.489

High

397672

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

2

High-throughput

0.489

High

878033

YIF1B
Protein YIF1B

1

2

High-throughput

0.489

High

878052

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

1

High-throughput

0.489

High

878058

ZNT7
Zinc transporter 7

1

9

High-throughput

0.489

High

878071

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.489

High

878090

UN93B
Protein unc-93 homolog B1

1

2

High-throughput

0.489

High

878094

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.489

High

878105

CLDN1
Claudin domain-containing protein 1

1

1

High-throughput

0.489

High

878113

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

1

High-throughput

0.489

High

217955

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.479

High

362962

EGFR
Epidermal growth factor receptor

1

16

High-throughput

0.479

High

410710

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

16

High-throughput

0.479

High

466150

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

557174

SRC
Proto-oncogene tyrosine-protein kinase Src

1

8

High-throughput

0.479

High

774202

BASI
Basigin

1

5

High-throughput

0.479

High

878008

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

878010

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

878011

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

878012

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

878014

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

878016

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

878018

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

878024

CUL3
Cullin-3

1

8

High-throughput

0.479

High

878027

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

878075

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

878092

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

878093

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

878096

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

878051

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.460

High

878069

AP2C
Transcription factor AP-2 gamma

1

1

High-throughput

0.457

High

76352

B4DQ88
cDNA FLJ52014, highly similar to EGF-like module-containing mucin-like hormone receptor-like 2

1

1

High-throughput

0.445

High

170700

CLGN
Calmegin

1

8

High-throughput

0.445

High

256008

S19A2
Thiamine transporter 1

1

3

High-throughput

0.445

High

641924

CD9
CD9 antigen

1

12

High-throughput

0.445

High

702750

5HT2C
5-hydroxytryptamine receptor 2C

1

7

High-throughput

0.445

High

703998

5HT1E
5-hydroxytryptamine receptor 1E

1

4

High-throughput

0.445

High

722413

CTR1
High affinity cationic amino acid transporter 1

1

9

High-throughput

0.445

High

868050

OR1D4
Olfactory receptor 1D4

1

3

High-throughput

0.445

High

878006

CCR9
C-C chemokine receptor type 9

1

11

High-throughput

0.445

High

878009

CD81
CD81 antigen

1

12

High-throughput

0.445

High

878013

TSN5
Tetraspanin-5

1

14

High-throughput

0.445

High

878021

TRDN
Triadin

1

2

High-throughput

0.445

High

878039

MFSD5
Molybdate-anion transporter

1

5

High-throughput

0.445

High

878040

NPAL3
NIPA-like protein 3

1

5

High-throughput

0.445

High

878041

S39A4
Zinc transporter ZIP4

1

13

High-throughput

0.445

High

878048

S35F2
Solute carrier family 35 member F2

1

8

High-throughput

0.445

High

878056

MFSD9
Major facilitator superfamily domain-containing protein 9

1

4

High-throughput

0.445

High

878066

S39A7
Zinc transporter SLC39A7

1

13

High-throughput

0.445

High

878077

MF14A
Hippocampus abundant transcript 1 protein

1

6

High-throughput

0.445

High

878081

S1PR3
Sphingosine 1-phosphate receptor 3

1

11

High-throughput

0.445

High

878007

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.437

High

878042

TMM88
Transmembrane protein 88

1

0

High-throughput

0.426

High

878064

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.426

High

878067

SL9A6
Sodium/hydrogen exchanger 6

1

0

High-throughput

0.426

High

878072

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.407

High

49443

TM223
Transmembrane protein 223

2

0

High-throughput

0.328

High

49636

T120B
Transmembrane protein 120B

2

0

High-throughput

0.328

High

328362

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

2

0

High-throughput

0.328

High

878017

RED1
Double-stranded RNA-specific editase 1

2

0

High-throughput

0.328

High

209751

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.279

Low

223608

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

223712

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.279

Low

690700

AOFB
Amine oxidase [flavin-containing] B

1

0

High-throughput

0.279

Low

878030

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.279

Low

878054

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.279

Low

878059

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.279

Low

878083

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.279

Low

878085

AFG2B
ATPase family gene 2 protein homolog B

1

0

High-throughput

0.279

Low

878089

XYLT2
Xylosyltransferase 2

1

0

High-throughput

0.279

Low

878025

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.251

Low

878032

MIDN
Midnolin

1

0

High-throughput

0.249

Low

878038

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025