HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: FBXW5 (Q969U6)
F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
Gene: FBXW5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	18381890, 36688959, 17079684, 22910413
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 566
+	Hs
		1043501 CUL4B_HUMAN (10-759): 0: 927: 82.31		FBXW5_HUMAN (1-566): 0: 1077: 100.00
+	Hs
		1042224 CUL3_HUMAN (32-759): 0: 814: 38.23		FBXW5_HUMAN (1-566): 0: 1077: 100.00
+	Hs
		1041137 CUL1_HUMAN (59-759): 0: 745: 30.55		FBXW5_HUMAN (1-566): 0: 1077: 100.00
+	Hs
		1041427 CUL2_HUMAN (51-759): 0: 710: 27.00		FBXW5_HUMAN (1-566): 0: 1077: 100.00