HitPredict

Interactor 1: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Interactor 2: DCA10 (Q5QP82)
DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)
Gene: DCAF10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	26496610, 31973889, 21145461
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Hs			1 559
+	Hs
		1043441 CUL4B_HUMAN (1-913): 0: 1184: 100.00		WDR5B_HUMAN (12-325): 5.26e-48: 171: 12.50
+	Hs
		152876 CUL4B_HUMAN (1-913): 0: 1184: 100.00		APAF_HUMAN (63-475): 1.84e-42: 165: 12.92
+	Hs
		1043469 CUL4B_HUMAN (1-913): 0: 1184: 100.00		POC1B_HUMAN (286-554): 4.01e-40: 154: 9.03
+	Hs
		1043568 CUL4B_HUMAN (1-913): 0: 1184: 100.00		SKI8_HUMAN (130-325): 4.55e-40: 149: 26.40
+	Hs
		1043509 CUL4B_HUMAN (1-913): 0: 1184: 100.00		SNR40_HUMAN (333-557): 6.41e-23: 102: 9.21
+	Hs
		903209 CUL4B_HUMAN (1-913): 0: 1184: 100.00		WDR5_HUMAN (404-558): 4.98e-21: 96.3: 13.55
+	Hs
		1043037 CUL4A_HUMAN (161-913): 0: 955: 81.83		DCA10_HUMAN (1-559): 4.4e-96: 305: 100.00
+	Hs
		1043562 CUL4B_HUMAN (1-913): 0: 1184: 100.00		TBL1R_HUMAN (378-557): 1.15e-12: 72.4: 7.74
+	Hs
		1043085 CUL4A_HUMAN (161-913): 0: 955: 81.83		WDR5B_HUMAN (12-325): 5.26e-48: 171: 12.50
+	Hs
		1043114 CUL4A_HUMAN (161-913): 0: 955: 81.83		POC1B_HUMAN (286-554): 4.01e-40: 154: 9.03
+	Hs
		1043208 CUL4A_HUMAN (161-913): 0: 955: 81.83		SKI8_HUMAN (130-325): 4.55e-40: 149: 26.40
+	Hs
		921556 CUL4A_HUMAN (161-913): 0: 955: 81.83		GBB2_HUMAN (184-555): 2.19e-26: 111: 13.64
+	Hs
		1043157 CUL4A_HUMAN (161-913): 0: 955: 81.83		SNR40_HUMAN (333-557): 6.41e-23: 102: 9.21
+	Hs
		903208 CUL4A_HUMAN (161-913): 0: 955: 81.83		WDR5_HUMAN (404-558): 4.98e-21: 96.3: 13.55
+	Hs
		792982 CUL4A_HUMAN (161-913): 0: 955: 81.83		LIS1_HUMAN (400-555): 6.63e-16: 81.7: 12.82
+	Hs
		1043340 CUL4A_HUMAN (161-913): 0: 955: 81.83		WSB1_HUMAN (171-322): 3.49e-13: 73.6: 22.56
+	Hs
		1043262 CUL4A_HUMAN (161-913): 0: 955: 81.83		WSB2_HUMAN (171-348): 7.11e-12: 69.4: 23.56
+	Hs
		152875 CUL3_HUMAN (186-913): 0: 853: 37.19		APAF_HUMAN (63-475): 1.84e-42: 165: 12.92
+	Hs
		903207 CUL3_HUMAN (186-913): 0: 853: 37.19		WDR5_HUMAN (404-558): 4.98e-21: 96.3: 13.55
+	Hs
		209433 CUL3_HUMAN (186-913): 0: 853: 37.19		PLRG1_HUMAN (390-555): 2.21e-14: 77.8: 9.28