HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: DLG3 (P70175)
Disks large homolog 3 (Synapse-associated protein 102) (SAP-102) (SAP102)
Gene: DLG3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	27507650, 28706196, 28671696, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C2~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1340 Mm			1 849
+	Hs
		1368714 SYGP1_HUMAN (1-1340): 0: 1060: 98.59		DLG3_HUMAN (1-849): 0: 678: 95.52
+	Rn
		1224329 SYGP1_RAT (1-1298): 0: 1028: 98.69		DLG3_RAT (1-849): 0: 706: 99.65
+	Mm
		104585 SYGP1_MOUSE (1-1340): 0: 1071: 100.00		DLG1_MOUSE (27-849): 0: 577: 67.31
+	Mm
		104543 SYGP1_MOUSE (1-1340): 0: 1071: 100.00		DLG4_MOUSE (104-849): 0: 573: 63.55
+	Hs
		1006093 SYGP1_HUMAN (1-1340): 0: 1060: 98.59		DLG4_HUMAN (104-849): 0: 574: 63.55
+	Rn
		723903 SYGP1_RAT (1-1298): 0: 1028: 98.69		DLG4_RAT (104-849): 0: 574: 63.42
+	Mm
		1190099 DAB2P_MOUSE (97-1339): 0: 849: 47.75		DLG4_MOUSE (104-849): 0: 573: 63.55
+	Mm
		104620 SYGP1_MOUSE (1-1340): 0: 1071: 100.00		DLG2_MOUSE (220-611): 3.28e-22: 104: 15.29
+	Mm
		1190773 IQGA2_MOUSE (216-731): 1.42e-115: 399: 14.09		DLG4_MOUSE (104-849): 0: 573: 63.55
+	Mm
		1223783 RASL1_MOUSE (162-702): 6.13e-120: 395: 18.95		DLG4_MOUSE (104-849): 0: 573: 63.55
+	Rn
		1021802 NF1_RAT (408-712): 7.34e-86: 312: 25.08		CSKP_RAT (49-352): 7.78e-22: 103: 10.86