Protein: DLG3
Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)

Gene: DLG3
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q92796

Gene Ontology (top 5):
GO:0001736 - establishment of planar polarity
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1091548

DLG1
Disks large homolog 1

3

19

High-throughput

0.861

High

1006087

DLG4
Disks large homolog 4

2

17

Small-scale

0.783

High

1368721

PKHA2
Pleckstrin homology domain-containing family A member 2

2

6

High-throughput

0.783

High

1229251

RHG17
Rho GTPase-activating protein 17

2

5

High-throughput

0.776

High

1368713

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

10

High-throughput

0.776

High

375800

RASK
GTPase KRas

2

20

High-throughput

0.754

High

1368708

OSBP2
Oxysterol-binding protein 2

2

0

High-throughput

0.742

High

1098529

NMDE2
Glutamate receptor ionotropic, NMDA 2B

6

20

Small-scale

0.729

High

967894

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

Small-scale

0.724

High

1125290

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.724

High

1368714

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

11

Small-scale

0.713

High

168730

CSKP
Peripheral plasma membrane protein CASK

1

15

High-throughput

0.691

High

1152416

DLG2
Disks large homolog 2

1

18

High-throughput

0.691

High

1368711

ARHGQ
Rho guanine nucleotide exchange factor 26

1

13

High-throughput

0.691

High

1368718

RGAP1
Rac GTPase-activating protein 1

1

2

High-throughput

0.691

High

402978

ANXA1
Annexin A1

1

1

High-throughput

0.665

High

1088782

NMDE1
Glutamate receptor ionotropic, NMDA 2A

3

20

Small-scale

0.665

High

1145761

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

Small-scale

0.656

High

1368727

DLGP2
Disks large-associated protein 2

3

20

High-throughput

0.653

High

1279514

ARHG8
Neuroepithelial cell-transforming gene 1 protein

1

10

High-throughput

0.647

High

292496

RHBL1
Rhomboid-related protein 1

3

0

High-throughput

0.638

High

1133905

NMDE3
Glutamate receptor ionotropic, NMDA 2C

2

20

Small-scale

0.629

High

1368731

ZN232
Zinc finger protein 232

2

2

High-throughput

0.628

High

159776

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

19

High-throughput

0.618

High

374826

RASH
GTPase HRas

1

18

High-throughput

0.618

High

601396

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

710408

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

953602

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

962343

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

978210

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1015652

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1150213

TEAD4
Transcriptional enhancer factor TEF-3

3

1

High-throughput

0.609

High

399606

VTNC
Vitronectin

2

1

High-throughput

0.606

High

969344

RS8
Small ribosomal subunit protein eS8

2

1

High-throughput

0.606

High

1368736

GUAD
Guanine deaminase

1

1

Small-scale

0.589

High

154400

DLGP1
Disks large-associated protein 1

2

20

Small-scale

0.584

High

1140260

IF4H
Eukaryotic translation initiation factor 4H

2

0

High-throughput

0.580

High

1135552

FRPD4
FERM and PDZ domain-containing protein 4

1

10

High-throughput

0.579

High

246076

KIF1B
Kinesin-like protein KIF1B

1

17

High-throughput

0.575

High

1260704

HECW1
E3 ubiquitin-protein ligase HECW1

1

10

High-throughput

0.575

High

1368710

EXOC4
Exocyst complex component 4

1

3

Small-scale

0.573

High

396645

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

1368726

CRIPT
Cysteine-rich PDZ-binding protein

1

3

Small-scale

0.561

High

665000

ERD21
ER lumen protein-retaining receptor 1

2

1

High-throughput

0.553

High

648789

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

20

High-throughput

0.536

High

1179629

RGPA2
Ral GTPase-activating protein subunit alpha-2

1

5

High-throughput

0.536

High

1310278

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

1332090

EIF1A
Probable RNA-binding protein EIF1AD

1

2

High-throughput

0.536

High

1339429

NBEA
Neurobeachin

1

2

High-throughput

0.536

High

1351925

RBCC1
RB1-inducible coiled-coil protein 1

1

8

High-throughput

0.536

High

1368735

DLGP4
Disks large-associated protein 4

1

20

High-throughput

0.536

High

106390

APRIO
Alternative prion protein

2

6

High-throughput

0.533

High

668681

APC
Adenomatous polyposis coli protein

1

15

Small-scale

0.527

High

300452

KRT34
Keratin, type I cuticular Ha4

1

6

High-throughput

0.515

High

980979

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.515

High

1007535

KRT85
Keratin, type II cuticular Hb5

1

4

High-throughput

0.515

High

1112939

CUL2
Cullin-2

1

5

High-throughput

0.515

High

1146081

K1H1
Keratin, type I cuticular Ha1

1

6

High-throughput

0.515

High

1367967

KRT35
Keratin, type I cuticular Ha5

1

6

High-throughput

0.515

High

1368715

KLDC3
Kelch domain-containing protein 3

1

1

High-throughput

0.515

High

1368723

KRT82
Keratin, type II cuticular Hb2

1

4

High-throughput

0.515

High

1368733

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

15

High-throughput

0.515

High

1368728

HECW2
E3 ubiquitin-protein ligase HECW2

1

10

High-throughput

0.514

High

1368719

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.513

High

185896

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

1368722

CLTR2
Cysteinyl leukotriene receptor 2

1

19

High-throughput

0.501

High

1368732

EXOC7
Exocyst complex component 7

1

1

Small-scale

0.501

High

754589

S10A3
Protein S100-A3

1

0

High-throughput

0.493

High

126159

AP3B1
AP-3 complex subunit beta-1

1

3

High-throughput

0.489

High

1130013

KCTD2
BTB/POZ domain-containing protein KCTD2

1

10

High-throughput

0.489

High

1200462

COBL1
Cordon-bleu protein-like 1

1

7

High-throughput

0.489

High

1233132

RGPA1
Ral GTPase-activating protein subunit alpha-1

1

5

High-throughput

0.489

High

1288353

TLK2
Serine/threonine-protein kinase tousled-like 2

1

7

High-throughput

0.489

High

1293032

RLGPB
Ral GTPase-activating protein subunit beta

1

2

High-throughput

0.489

High

1368712

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

1

High-throughput

0.489

High

1368716

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.489

High

791595

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

1022637

LRP2
Low-density lipoprotein receptor-related protein 2

1

8

Small-scale

0.481

High

1324499

NLGN1
Neuroligin-1

1

19

Small-scale

0.481

High

1339603

NLGN2
Neuroligin-2

1

19

Small-scale

0.481

High

1368717

SEM4C
Semaphorin-4C

1

7

Small-scale

0.481

High

1368725

NLGN3
Neuroligin-3

1

19

Small-scale

0.481

High

62062

WDR91
WD repeat-containing protein 91

1

6

High-throughput

0.479

High

338016

ABCA1
Phospholipid-transporting ATPase ABCA1

1

1

Small-scale

0.479

High

347852

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

661310

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

10

Small-scale

0.479

High

752045

GCYA2
Guanylate cyclase soluble subunit alpha-2

1

8

Small-scale

0.479

High

1024121

TFAM
Transcription factor A, mitochondrial

1

2

High-throughput

0.479

High

1032633

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

10

Small-scale

0.479

High

1092405

GRIK2
Glutamate receptor ionotropic, kainate 2

1

20

Small-scale

0.479

High

1113895

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1127300

KCJ12
ATP-sensitive inward rectifier potassium channel 12

1

20

Small-scale

0.479

High

1157441

GRIK5
Glutamate receptor ionotropic, kainate 5

1

20

Small-scale

0.479

High

1326501

ARL14
ADP-ribosylation factor-like protein 14

1

9

High-throughput

0.479

High

1340768

COP1
E3 ubiquitin-protein ligase COP1

1

1

Small-scale

0.479

High

1235211

Q6IS01
DLGAP1 protein

1

20

High-throughput

0.470

High

252891

EXOC3
Exocyst complex component 3

1

0

Small-scale

0.458

High

504695

F163B
Protein FAM163B

1

2

High-throughput

0.457

High

248996

EVI5
Ecotropic viral integration site 5 protein homolog

1

3

High-throughput

0.445

High

404862

PRIO
Major prion protein

1

3

High-throughput

0.445

High

1206647

TJAP1
Tight junction-associated protein 1

1

6

High-throughput

0.445

High

700418

AOAH
Acyloxyacyl hydrolase

1

1

High-throughput

0.439

High

1368720

RPF2
Ribosome production factor 2 homolog

1

1

High-throughput

0.439

High

1368709

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

1368724

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.437

High

1059911

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

Small-scale

0.408

High

4755

A0A1B0GTN4
DLG associated protein 2

1

20

High-throughput

0.407

High

91532

C9J1X0
WD repeat-containing protein 91

1

6

High-throughput

0.407

High

117033

J3KQY1
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.407

High

1368734

CNPY2
Protein canopy homolog 2

2

0

High-throughput

0.328

High

1248609

DHR11
Dehydrogenase/reductase SDR family member 11

2

0

High-throughput

0.316

High

1103838

TARB1
tRNA

1

0

High-throughput

0.279

Low

1368729

S18L2
SS18-like protein 2

1

0

High-throughput

0.279

Low

1368730

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025