HitPredict

Interactor 1: MRT2 (G5EC44)
Cell cycle checkpoint protein RAD1 homolog mrt-2 (EC 3.1.11.2)
Gene: mrt-2

Interactor 2: G5EFI9 (G5EFI9)
Checkpoint protein
Gene: hus-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.937

Property	Details
Experiments	19123269, 12679813, 11778048, 12445383, 14704431
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hus1~Rad1
Common GO terms	GO:0000077 - DNA damage checkpoint signaling GO:0000723 - telomere maintenance GO:0005634 - nucleus GO:0006289 - nucleotide-excision repair GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage and 1 others more... GO:0030896 - checkpoint clamp complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 267 Ce			1 277
+	Hs
		245873 PCNA_HUMAN (1-267): 3.41e-91: 271: 14.96		HUS1_HUMAN (1-276): 4.13e-110: 321: 29.17
+	Hs
		238247 RAD1_HUMAN (16-265): 6.09e-80: 244: 28.79		HUS1_HUMAN (1-276): 4.13e-110: 321: 29.17
+	Hs
		238276 RAD1_HUMAN (16-265): 6.09e-80: 244: 28.79		HUS1B_HUMAN (1-275): 1.68e-99: 294: 23.35
+	Dm
		1371279 Q9VQD4_DROME (6-267): 2.55e-72: 224: 21.56		Q9VN60_DROME (1-275): 3.72e-97: 288: 22.34
+	Sp
		605289 RAD1_SCHPO (19-264): 2.14e-64: 205: 20.88		HUS1_SCHPO (1-277): 3.05e-89: 268: 17.00