HitPredict

Interactor 1: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.864

Property	Details
Experiments	34079125, 33961781, 15975580
Identification Methods	proximity labelling technology, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0044291 - cell-cell contact zone GO:0045296 - cadherin binding and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1630 Hs			1 1190
+	Hs
		159190 DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Mm
		1143555 DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42		MPP2_MOUSE (426-888): 3.06e-95: 317: 16.15
+	Hs
		942375 LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Hs
		1021557 LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Dm
		677695 SCRIB_DROME (1-258): 6.81e-66: 249: 37.98		DLG1_DROME (12-421): 3.86e-35: 147: 17.36
+	Hs
		942321 DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		1143321 DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		942349 DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42		DLG2_HUMAN (8-518): 4.46e-45: 178: 15.49
+	Mm
		1143467 DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42		DLG2_MOUSE (8-534): 5.21e-45: 178: 15.58
+	Mm
		1143387 DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42		DLG1_MOUSE (1-513): 1.74e-44: 177: 16.44
+	Mm
		1113136 DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42		Q3UP61_MOUSE (8-513): 2.78e-44: 176: 16.28
+	Rn
		677787 DLG4_RAT (812-1187): 3.08e-49: 190: 22.42		DLG1_RAT (1-513): 8.04e-44: 174: 16.64
+	Hs
		942364 DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42		DLG3_HUMAN (2-318): 5.99e-23: 107: 16.61
+	Mm
		1119795 DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42		Q52KF7_MOUSE (2-318): 5.84e-23: 107: 16.61
+	Hs
		280053 MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Rn
		1144014 DLG2_RAT (587-879): 2.66e-21: 103: 18.52		DLG1_RAT (1-513): 8.04e-44: 174: 16.64
+	Rn
		677790 DLG4_RAT (812-1187): 3.08e-49: 190: 22.42		DLG3_RAT (372-595): 5.53e-13: 75.5: 18.10
+	Mm
		936180 DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42		DLG3_MOUSE (372-595): 5.97e-13: 75.5: 18.10
+	Mm
		936188 DLG2_MOUSE (587-879): 2.8e-21: 103: 18.52		DLG3_MOUSE (372-595): 5.97e-13: 75.5: 18.10