Protein: RTN2
Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI)

Gene: RTN2
Organism: Homo sapiens
Interactions: 120
UniProt ID: O75298

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005882 - intermediate filament
GO:0007420 - brain development
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

275566

RTN4
Reticulon-4

4

15

High-throughput

0.699

High

275564

JPH1
Junctophilin-1

3

1

High-throughput

0.667

High

275480

VTNC
Vitronectin

2

1

High-throughput

0.628

High

275522

RTN1
Reticulon-1

2

15

High-throughput

0.628

High

275544

LPAR1
Lysophosphatidic acid receptor 1

2

3

High-throughput

0.611

High

275575

AT1B4
Protein ATP1B4

3

4

High-throughput

0.609

High

275475

RTN3
Reticulon-3

2

15

High-throughput

0.601

High

275481

GLPB
Glycophorin-B

2

1

High-throughput

0.574

High

275489

FPR2
N-formyl peptide receptor 2

2

7

High-throughput

0.574

High

275503

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

2

4

High-throughput

0.558

High

275524

TM128
Transmembrane protein 128

2

3

High-throughput

0.558

High

275478

TSN15
Tetraspanin-15

1

4

High-throughput

0.536

High

275483

CD63
CD63 antigen

1

4

High-throughput

0.536

High

275492

COPB2
Coatomer subunit beta'

1

5

High-throughput

0.536

High

275502

COPA
Coatomer subunit alpha

1

6

High-throughput

0.536

High

275572

VAPA
Vesicle-associated membrane protein-associated protein A

1

8

High-throughput

0.536

High

275493

INGR2
Interferon gamma receptor 2

1

0

High-throughput

0.513

High

275521

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

275546

LDAF1
Lipid droplet assembly factor 1

1

0

High-throughput

0.513

High

275574

NAT8B
N-acetyltransferase 8B

1

0

High-throughput

0.513

High

275576

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.513

High

275488

COT2
COUP transcription factor 2

1

1

High-throughput

0.489

High

275494

GPV
Platelet glycoprotein V

1

5

High-throughput

0.489

High

275510

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.489

High

275511

MALL
MAL-like protein

1

1

High-throughput

0.489

High

275532

SVOPL
Putative transporter SVOPL

1

5

High-throughput

0.489

High

275535

F241A
Uncharacterized protein FAM241A

1

3

High-throughput

0.489

High

275541

SFT2A
Vesicle transport protein SFT2A

1

1

High-throughput

0.489

High

275548

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

1

High-throughput

0.489

High

275550

TM169
Transmembrane protein 169

1

3

High-throughput

0.489

High

275560

TSN10
Tetraspanin-10

1

4

High-throughput

0.489

High

275529

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

48457

ESYT2
Extended synaptotagmin-2

1

7

High-throughput

0.445

High

50457

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.445

High

60271

NBAS
NBAS subunit of NRZ tethering complex

1

2

High-throughput

0.445

High

104307

F5H6I7
Atlastin GTPase 3

1

11

High-throughput

0.445

High

158064

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.445

High

211695

ZW10
Centromere/kinetochore protein zw10 homolog

1

2

High-throughput

0.445

High

215465

EMC8
ER membrane protein complex subunit 8

1

2

High-throughput

0.445

High

275472

ERLN1
Erlin-1

1

3

High-throughput

0.445

High

275477

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

8

High-throughput

0.445

High

275479

NB5R3
NADH-cytochrome b5 reductase 3

1

4

High-throughput

0.445

High

275484

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.445

High

275486

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

4

High-throughput

0.445

High

275490

CALR
Calreticulin

1

7

High-throughput

0.445

High

275491

CALX
Calnexin

1

7

High-throughput

0.445

High

275495

COPD
Coatomer subunit delta

1

2

High-throughput

0.445

High

275498

TMEDA
Transmembrane emp24 domain-containing protein 10

1

8

High-throughput

0.445

High

275499

SSRD
Translocon-associated protein subunit delta

1

2

High-throughput

0.445

High

275500

BAP31
B-cell receptor-associated protein 31

1

4

High-throughput

0.445

High

275501

COPB
Coatomer subunit beta

1

2

High-throughput

0.445

High

275505

COPZ1
Coatomer subunit zeta-1

1

2

High-throughput

0.445

High

275506

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.445

High

275507

NUCB2
Nucleobindin-2

1

2

High-throughput

0.445

High

275509

REEP5
Receptor expression-enhancing protein 5

1

7

High-throughput

0.445

High

275512

PRDX4
Peroxiredoxin-4

1

4

High-throughput

0.445

High

275513

GANAB
Neutral alpha-glucosidase AB

1

3

High-throughput

0.445

High

275514

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.445

High

275515

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

2

High-throughput

0.445

High

275516

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

2

High-throughput

0.445

High

275517

RCN1
Reticulocalbin-1

1

2

High-throughput

0.445

High

275518

TMED2
Transmembrane emp24 domain-containing protein 2

1

8

High-throughput

0.445

High

275519

DHC24
Delta(24)-sterol reductase

1

3

High-throughput

0.445

High

275520

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

5

High-throughput

0.445

High

275523

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

10

High-throughput

0.445

High

275528

LCLT1
Lysocardiolipin acyltransferase 1

1

2

High-throughput

0.445

High

275531

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

5

High-throughput

0.445

High

275533

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

2

High-throughput

0.445

High

275534

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.445

High

275536

DHB11
Estradiol 17-beta-dehydrogenase 11

1

10

High-throughput

0.445

High

275537

PDZD8
PDZ domain-containing protein 8

1

2

High-throughput

0.445

High

275539

ATLA2
Atlastin-2

1

11

High-throughput

0.445

High

275540

MCFD2
Multiple coagulation factor deficiency protein 2

1

2

High-throughput

0.445

High

275542

SCFD1
Sec1 family domain-containing protein 1

1

3

High-throughput

0.445

High

275543

ATLA1
Atlastin-1

1

11

High-throughput

0.445

High

275545

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.445

High

275547

ASTRA
Protein Aster-A

1

2

High-throughput

0.445

High

275554

ERP44
Endoplasmic reticulum resident protein 44

1

4

High-throughput

0.445

High

275555

ESYT1
Extended synaptotagmin-1

1

7

High-throughput

0.445

High

275558

LNP
Endoplasmic reticulum junction formation protein lunapark

1

6

High-throughput

0.445

High

275561

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

2

High-throughput

0.445

High

275562

TMX1
Thioredoxin-related transmembrane protein 1

1

7

High-throughput

0.445

High

275565

APMAP
Adipocyte plasma membrane-associated protein

1

3

High-throughput

0.445

High

275567

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

3

High-throughput

0.445

High

275568

TM38B
Trimeric intracellular cation channel type B

1

2

High-throughput

0.445

High

275570

PSD3
PH and SEC7 domain-containing protein 3

1

2

High-throughput

0.445

High

275571

TECR
Very-long-chain enoyl-CoA reductase

1

2

High-throughput

0.445

High

275573

COPG2
Coatomer subunit gamma-2

1

5

High-throughput

0.445

High

275577

DHRS7
Dehydrogenase/reductase SDR family member 7

1

9

High-throughput

0.445

High

275578

TMED5
Transmembrane emp24 domain-containing protein 5

1

8

High-throughput

0.445

High

275580

COPG1
Coatomer subunit gamma-1

1

5

High-throughput

0.445

High

85140

B7Z3K1
cDNA FLJ51973

1

3

High-throughput

0.407

High

213542

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

2

High-throughput

0.407

High

255940

S19A2
Thiamine transporter 1

1

2

High-throughput

0.407

High

275473

STAM2
Signal transducing adapter molecule 2

1

3

High-throughput

0.407

High

275474

MICA2
[F-actin]-monooxygenase MICAL2

1

3

High-throughput

0.407

High

275482

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

High-throughput

0.407

High

275496

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.407

High

275497

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

2

High-throughput

0.407

High

275508

ARF5
ADP-ribosylation factor 5

1

5

High-throughput

0.407

High

275530

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

2

High-throughput

0.407

High

275538

VP37A
Vacuolar protein sorting-associated protein 37A

1

2

High-throughput

0.407

High

275551

SCYL1
N-terminal kinase-like protein

1

5

High-throughput

0.407

High

275552

NUDC1
NudC domain-containing protein 1

1

2

High-throughput

0.407

High

275553

PXL2A
Peroxiredoxin-like 2A

1

3

High-throughput

0.407

High

275556

NDC1
Nucleoporin NDC1

1

2

High-throughput

0.407

High

275557

WDR11
WD repeat-containing protein 11

1

2

High-throughput

0.407

High

275559

RGAP1
Rac GTPase-activating protein 1

1

4

High-throughput

0.407

High

275569

GPTC2
G patch domain-containing protein 2

1

2

High-throughput

0.407

High

275579

SERC
Phosphoserine aminotransferase

1

2

High-throughput

0.407

High

275476

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

0

High-throughput

0.347

High

275485

ICAM2
Intercellular adhesion molecule 2

3

0

High-throughput

0.347

High

275549

MCRS1
Microspherule protein 1

3

0

High-throughput

0.347

High

275563

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.328

High

275504

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.279

Low

275525

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

275526

SYPL2
Synaptophysin-like protein 2

1

0

High-throughput

0.279

Low

275527

CK087
Uncharacterized protein C11orf87

1

0

High-throughput

0.279

Low

185131

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.251

Low

275487

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025