HitPredict

Interactor 1: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 716 Hs			1 999
+	Hs
		850687 KS6A3_HUMAN (6-294): 2.42e-88: 294: 22.34		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		714362 MARK4_HUMAN (9-262): 3.68e-86: 289: 28.21		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		504064 IKKE_HUMAN (1-716): 1.32e-170: 508: 100.00		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		1050214 IKKE_HUMAN (1-716): 1.32e-170: 508: 100.00		Q53FC7_HUMAN (682-813): 3.1e-27: 120: 20.46
+	Hs
		504911 TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		158411 IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97		HS71L_HUMAN (682-814): 9.92e-31: 131: 15.04
+	Hs
		158382 IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		254440 ROCK2_HUMAN (7-705): 1.81e-120: 393: 16.15		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		503719 KS6A3_HUMAN (6-294): 2.42e-88: 294: 22.34		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		504119 KS6A1_HUMAN (4-348): 2.36e-88: 294: 20.17		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		564041 KS6A3_HUMAN (6-294): 2.42e-88: 294: 22.34		HSP76_HUMAN (682-813): 1.1e-27: 121: 19.70
+	Hs
		564080 KS6A1_HUMAN (4-348): 2.36e-88: 294: 20.17		HSP76_HUMAN (682-813): 1.1e-27: 121: 19.70
+	Dm
		332639 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP68_DROME (33-607): 3.18e-61: 222: 29.89
+	Dm
		505090 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP7D_DROME (682-814): 2.14e-27: 121: 16.54
+	Dm
		669799 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP7A_DROME (682-821): 1.64e-26: 118: 17.14
+	Dm
		365410 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP71_DROME (682-832): 2.86e-24: 111: 15.23
+	Dm
		1213523 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP72_DROME (682-815): 6.5e-24: 109: 15.67
+	Dm
		1365056 IKKB_DROME (1-317): 5.09e-29: 125: 31.77		HSP74_DROME (682-815): 7.74e-24: 109: 15.67