Protein: TBL1X
F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)

Gene: TBL1X
Organism: Homo sapiens
Interactions: 122
UniProt ID: O60907

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

261440

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

4

17

Small-scale

0.890

High

261392

H4
Histone H4

3

7

Small-scale

0.834

High

261437

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

15

High-throughput

0.811

High

261352

TBL1X
F-box-like/WD repeat-containing protein TBL1X

2

16

Small-scale

0.799

High

261378

ARL3
ADP-ribosylation factor-like protein 3

2

7

High-throughput

0.783

High

261413

H2B2E
Histone H2B type 2-E

2

6

Small-scale

0.768

High

261404

GPS2
G protein pathway suppressor 2

8

2

Small-scale

0.756

High

261442

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

2

11

Small-scale

0.754

High

261354

NCOR1
Nuclear receptor corepressor 1

8

20

Small-scale

0.753

High

188125

HDAC3
Histone deacetylase 3

8

16

Small-scale

0.753

High

261459

NCOR2
Nuclear receptor corepressor 2

5

20

Small-scale

0.726

High

261419

WDR59
GATOR2 complex protein WDR59

2

18

High-throughput

0.726

High

261411

DDB1
DNA damage-binding protein 1

1

10

Small-scale

0.724

High

261458

T22D4
TSC22 domain family protein 4

3

4

High-throughput

0.667

High

261425

HORM2
HORMA domain-containing protein 2

1

0

High-throughput

0.656

High

261456

HDAC5
Histone deacetylase 5

3

20

Small-scale

0.656

High

261396

FOXK2
Forkhead box protein K2

2

11

Small-scale

0.649

High

261382

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

Small-scale

0.647

High

261387

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

5

Small-scale

0.647

High

261395

UBC9
SUMO-conjugating enzyme UBC9

1

7

Small-scale

0.647

High

261418

H2A2A
Histone H2A type 2-A

1

7

Small-scale

0.647

High

261420

H32
Histone H3.2

1

12

Small-scale

0.647

High

261373

CTNB1
Catenin beta-1

3

13

Small-scale

0.640

High

261423

MKX
Homeobox protein Mohawk

2

5

High-throughput

0.628

High

261377

ARL2
ADP-ribosylation factor-like protein 2

1

6

High-throughput

0.621

High

261435

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.618

High

261394

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.618

High

261432

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

5

Small-scale

0.618

High

261436

SIN3A
Paired amphipathic helix protein Sin3a

1

2

Small-scale

0.618

High

261362

THB
Thyroid hormone receptor beta

2

20

Small-scale

0.602

High

261385

ERF
ETS domain-containing transcription factor ERF

2

15

High-throughput

0.601

High

261386

MECP2
Methyl-CpG-binding protein 2

2

7

Small-scale

0.594

High

142745

NFIB
Nuclear factor 1 B-type

2

10

High-throughput

0.584

High

261359

NFIC
Nuclear factor 1 C-type

2

18

High-throughput

0.584

High

261401

NFIA
Nuclear factor 1 A-type

2

15

High-throughput

0.584

High

261410

NFIX
Nuclear factor 1 X-type

2

16

High-throughput

0.584

High

261358

PAI2
Plasminogen activator inhibitor 2

2

4

High-throughput

0.574

High

261414

LRC36
Leucine-rich repeat-containing protein 36

2

5

High-throughput

0.574

High

261353

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

10

High-throughput

0.558

High

261388

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.552

High

261439

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.549

High

221014

HAIR
Lysine-specific demethylase hairless

1

2

High-throughput

0.541

High

249314

DLX3
Homeobox protein DLX-3

1

5

High-throughput

0.541

High

155265

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

2

High-throughput

0.536

High

261356

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

261371

TKT
Transketolase

1

3

High-throughput

0.536

High

261400

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

261408

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

261415

EFMT2
EEF1A lysine methyltransferase 2

1

1

High-throughput

0.536

High

261429

HDAC7
Histone deacetylase 7

1

20

High-throughput

0.536

High

261438

KLDC3
Kelch domain-containing protein 3

1

5

High-throughput

0.536

High

261444

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

167201

KLF11
Krueppel-like factor 11

1

14

High-throughput

0.515

High

261368

DNJB1
DnaJ homolog subfamily B member 1

1

13

High-throughput

0.515

High

261434

IL17F
Interleukin-17F

1

0

High-throughput

0.513

High

261441

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.513

High

261361

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.501

High

261449

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

9

Small-scale

0.501

High

261383

DGKG
Diacylglycerol kinase gamma

1

2

High-throughput

0.489

High

261433

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.489

High

261450

HAOX2
2-Hydroxyacid oxidase 2

1

1

High-throughput

0.489

High

261457

CCL26
C-C motif chemokine 26

1

1

High-throughput

0.489

High

261399

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

5

High-throughput

0.481

High

261453

DNJB4
DnaJ homolog subfamily B member 4

1

13

High-throughput

0.481

High

172318

XPO1
Exportin-1

1

14

High-throughput

0.479

High

181480

TBXT
T-box transcription factor T

1

4

High-throughput

0.479

High

224917

TLX3
T-cell leukemia homeobox protein 3

1

13

High-throughput

0.479

High

226500

TLX2
T-cell leukemia homeobox protein 2

1

7

High-throughput

0.479

High

229490

NRDC
Nardilysin

1

1

Small-scale

0.479

High

246327

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.479

High

259197

BRD4
Bromodomain-containing protein 4

1

15

High-throughput

0.479

High

261360

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

261363

MYOD1
Myoblast determination protein 1

1

1

High-throughput

0.479

High

261364

GATA1
Erythroid transcription factor

1

10

High-throughput

0.479

High

261365

PAX7
Paired box protein Pax-7

1

4

High-throughput

0.479

High

261366

GATA2
Endothelial transcription factor GATA-2

1

10

High-throughput

0.479

High

261367

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

10

High-throughput

0.479

High

261369

PAX6
Paired box protein Pax-6

1

4

High-throughput

0.479

High

261372

TLX1
T-cell leukemia homeobox protein 1

1

14

High-throughput

0.479

High

261374

HNF1B
Hepatocyte nuclear factor 1-beta

1

6

High-throughput

0.479

High

261375

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

261376

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

261379

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

261380

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

261381

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

261384

EMD
Emerin

1

2

Small-scale

0.479

High

261389

PAX9
Paired box protein Pax-9

1

4

High-throughput

0.479

High

261390

HDAC4
Histone deacetylase 4

1

20

High-throughput

0.479

High

261391

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

261393

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

Small-scale

0.479

High

261397

TF65
Transcription factor p65

1

4

Small-scale

0.479

High

261398

HME1
Homeobox protein engrailed-1

1

3

High-throughput

0.479

High

261402

FOXI1
Forkhead box protein I1

1

10

High-throughput

0.479

High

261403

FOXL1
Forkhead box protein L1

1

10

High-throughput

0.479

High

261405

CTBP1
C-terminal-binding protein 1

1

7

Small-scale

0.479

High

261406

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

261407

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

261409

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

4

High-throughput

0.479

High

261412

TBR1
T-box brain protein 1

1

4

High-throughput

0.479

High

261421

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

261422

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

4

Small-scale

0.479

High

261427

SP7
Transcription factor Sp7

1

12

High-throughput

0.479

High

261430

HDAC2
Histone deacetylase 2

1

20

High-throughput

0.479

High

261443

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

261445

NANOG
Homeobox protein NANOG

1

16

High-throughput

0.479

High

261451

VSX1
Visual system homeobox 1

1

5

High-throughput

0.479

High

261454

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

261455

RCOR1
REST corepressor 1

1

16

High-throughput

0.479

High

261355

PRDM1
PR domain zinc finger protein 1

1

0

High-throughput

0.458

High

261370

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

261431

LHX4
LIM/homeobox protein Lhx4

1

0

High-throughput

0.458

High

261446

CYBP
Calcyclin-binding protein

1

0

Small-scale

0.458

High

261447

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

261428

TCP1L
T-complex protein 10A homolog 1

1

2

High-throughput

0.445

High

261424

ZDH23
Palmitoyltransferase ZDHHC23

1

4

Small-scale

0.437

High

261448

ZDH18
Palmitoyltransferase ZDHHC18

1

3

Small-scale

0.437

High

261452

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

5

High-throughput

0.407

High

261416

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

261417

SPT46
Spermatogenesis-associated protein 46

1

0

High-throughput

0.279

Low

261426

LY65B
Lymphocyte antigen 6 complex locus protein G5b

1

0

High-throughput

0.279

Low

261357

HPT
Haptoglobin

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025