HitPredict

Interactor 1: G5ECY6 (G5ECY6)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (RING-type E3 ubiquitin transferase CHIP)
Gene: chn-1

Interactor 2: HSP1 (P09446)
Heat shock protein hsp-1 (Heat shock 70 kDa protein A)
Gene: hsp-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	15294159, 36027913, 20047968
Identification Methods	two hybrid, pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008340 - determination of adult lifespan
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 266 Ce			1 640
+	Hs
		714095 CHIP_HUMAN (2-257): 9e-59: 190: 38.99		HS71L_HUMAN (2-640): 0: 953: 80.60
+	Mm
		926173 CHIP_MOUSE (2-257): 3.15e-59: 192: 38.63		HSP7C_MOUSE (1-614): 0: 942: 86.32
+	Mm
		571871 CHIP_MOUSE (2-257): 3.15e-59: 192: 38.63		HS71B_MOUSE (1-640): 0: 941: 80.09
+	Hs
		504954 CHIP_HUMAN (2-257): 9e-59: 190: 38.99		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		564209 CHIP_HUMAN (2-257): 9e-59: 190: 38.99		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Hs
		483811 CHIP_HUMAN (2-257): 9e-59: 190: 38.99		HS71B_HUMAN (1-640): 0: 933: 81.46
+	At
		1338010 CHIP_ARATH (2-258): 2.03e-55: 181: 30.71		HS704_ARATH (2-640): 0: 937: 76.01
+	Hs
		871829 CHIP_HUMAN (2-257): 9e-59: 190: 38.99		HSP72_HUMAN (2-640): 0: 925: 81.12
+	Dm
		505122 Q9XYW6_DROME (7-258): 2.6e-55: 181: 37.27		HSP7D_DROME (1-613): 0: 927: 84.18
+	Hs
		503738 PPP5_HUMAN (5-217): 2.52e-38: 141: 18.70		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		564043 PPP5_HUMAN (5-217): 2.52e-38: 141: 18.70		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Mm
		926131 PPP5_MOUSE (5-217): 4.7e-38: 141: 18.26		HSP7C_MOUSE (1-614): 0: 942: 86.32
+	At
		612321 OE64C_ARATH (3-117): 3.08e-34: 131: 27.59		HS701_ARATH (2-640): 0: 936: 75.27
+	Hs
		213468 SGTA_HUMAN (2-109): 9.01e-33: 123: 30.28		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Mm
		926144 SGTA_MOUSE (2-109): 1.27e-32: 123: 30.28		HSP7C_MOUSE (1-614): 0: 942: 86.32
+	At
		99225 OE64M_ARATH (2-117): 3.42e-33: 128: 27.35		HS701_ARATH (2-640): 0: 936: 75.27
+	Hs
		564188 RPAP3_HUMAN (3-209): 2.47e-30: 121: 16.35		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Dm
		505095 Q9VJD4_DROME (3-189): 1.06e-34: 129: 18.62		HSP7D_DROME (1-613): 0: 927: 84.18
+	Dm
		505082 Q9V3E9_DROME (3-205): 4.14e-31: 122: 17.07		HSP7D_DROME (1-613): 0: 927: 84.18
+	At
		1338008 HSOP1_ARATH (12-183): 1.85e-21: 95.2: 22.83		HS704_ARATH (2-640): 0: 937: 76.01