Protein: SPB6
Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor)

Gene: SPB6, SERPINB6
Organism: Homo sapiens
Interactions: 44
UniProt ID: P35237

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366536

TPA
Tissue-type plasminogen activator

2

20

High-throughput

0.811

High

767083

SPB8
Serpin B8

2

10

High-throughput

0.811

High

767104

KLK13
Kallikrein-13

2

20

High-throughput

0.789

High

628392

KLK2
Kallikrein-2

2

20

Small-scale

0.768

High

366097

THRB
Prothrombin

1

20

Small-scale

0.647

High

767094

TM11A
Transmembrane protease serine 11A

1

15

High-throughput

0.618

High

767095

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

240898

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

287875

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.541

High

767088

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

7

High-throughput

0.536

High

342767

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

411467

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

623147

RO52
E3 ubiquitin-protein ligase TRIM21

1

7

High-throughput

0.479

High

767081

CRK
Adapter molecule crk

1

3

High-throughput

0.479

High

767082

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.479

High

767086

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

767089

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

767090

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

767093

SOSD1
Sclerostin domain-containing protein 1

1

1

Small-scale

0.479

High

767097

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

767098

OPTN
Optineurin

1

1

High-throughput

0.479

High

767102

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

279290

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

550886

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

767103

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

142287

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.445

High

404705

PRIO
Major prion protein

1

2

High-throughput

0.445

High

767085

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

1

High-throughput

0.445

High

767101

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

767105

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

105451

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

371314

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

558962

LYL1
Protein lyl-1

1

2

High-throughput

0.437

High

588037

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

767080

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

767091

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.437

High

767092

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.437

High

767106

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

621440

HXK1
Hexokinase-1

1

0

High-throughput

0.426

High

767087

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.426

High

767096

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

767084

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.261

Low

767099

C170L
Cep170-like protein

1

0

High-throughput

0.249

Low

767100

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025