HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29656893, 37059091
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 1834
+	Hs
		1019017 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		801240 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		1173178 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		1154050 NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		801143 MDC1_HUMAN (1-2089): 0: 665: 100.00		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		1056827 MDC1_HUMAN (1-2089): 0: 665: 100.00		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Hs
		1056910 MDC1_HUMAN (1-2089): 0: 665: 100.00		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		1018956 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Hs
		1019050 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		1019194 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CABIN_HUMAN (880-1364): 9.59e-09: 63.1: 13.91
+	Hs
		1270850 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Mm
		1157867 PAXI1_MOUSE (1840-2081): 5.99e-54: 209: 29.80		KMT2C_MOUSE (886-1764): 1.24e-21: 105: 10.35
+	Hs
		152608 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		KMT2D_HUMAN (889-1742): 5.87e-09: 63.6: 9.85
+	Hs
		1056872 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Mm
		1157866 PAXI1_MOUSE (1840-2081): 5.99e-54: 209: 29.80		KMT2D_MOUSE (1288-1753): 3.78e-10: 67.8: 8.26
+	Hs
		152660 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2D_HUMAN (889-1742): 5.87e-09: 63.6: 9.85
+	Hs
		1303336 MUC4_HUMAN (143-1535): 2.62e-31: 137: 12.14		MUC4_HUMAN (854-1798): 2.2e-17: 91.7: 9.09
+	Hs
		801197 NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		311825 TACC2_HUMAN (151-1928): 1.23e-24: 115: 9.64		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57