HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: UIMC1 (Q96RL1)
BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)
Gene: UIMC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	21622030, 29656893, 22990118, 24240613
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016604 - nuclear body GO:0035861 - site of double-strand break
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 719
+	Hs
		1019092 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		UIMC1_HUMAN (1-719): 0: 1231: 100.00
+	Hs
		1173212 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		UIMC1_HUMAN (1-719): 0: 1231: 100.00