Protein: LMTK1
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)

Gene: LMTK1, AATK
Organism: Homo sapiens
Interactions: 189
UniProt ID: Q6ZMQ8

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0007420 - brain development
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1251972

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

20

Small-scale

0.757

High

1025475

CDK5
Cyclin-dependent kinase 5

1

20

Small-scale

0.747

High

410912

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.743

High

331768

MTMR5
Myotubularin-related protein 5

1

20

High-throughput

0.698

High

711143

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

20

High-throughput

0.698

High

1053688

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.698

High

1144531

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

461615

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.646

High

786684

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

12

Small-scale

0.637

High

767063

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

20

High-throughput

0.625

High

1050803

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.625

High

1251948

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

20

High-throughput

0.625

High

567011

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

2

5

High-throughput

0.618

High

1251963

ATD3A
ATPase family AAA domain-containing protein 3A

2

20

High-throughput

0.618

High

181800

EPHB6
Ephrin type-B receptor 6

1

19

High-throughput

0.618

High

213952

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

High-throughput

0.618

High

343605

OXSR1
Serine/threonine-protein kinase OSR1

1

20

High-throughput

0.618

High

443414

CDK1
Cyclin-dependent kinase 1

1

20

High-throughput

0.618

High

683859

MOES
Moesin

1

20

High-throughput

0.618

High

1251924

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.618

High

967812

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

3

12

Small-scale

0.615

High

767458

RADI
Radixin

1

20

High-throughput

0.578

High

1158391

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.578

High

1142244

CD5R1
Cyclin-dependent kinase 5 activator 1

1

4

Small-scale

0.573

High

968353

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

2

12

High-throughput

0.565

High

1153049

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

14

High-throughput

0.561

High

1040153

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

2

20

High-throughput

0.558

High

1194870

PTN20
Tyrosine-protein phosphatase non-receptor type 20

1

20

High-throughput

0.555

High

594026

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.553

High

1154109

ITSN1
Intersectin-1

1

20

High-throughput

0.553

High

1251926

MILK1
MICAL-like protein 1

1

20

High-throughput

0.553

High

1251929

EHBP1
EH domain-binding protein 1

1

20

High-throughput

0.553

High

1251937

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.553

High

1251967

ITSN2
Intersectin-2

1

20

High-throughput

0.553

High

290944

PPM1B
Protein phosphatase 1B

1

15

High-throughput

0.541

High

776976

PPM1A
Protein phosphatase 1A

1

13

High-throughput

0.541

High

884831

PPM1F
Protein phosphatase 1F

1

20

High-throughput

0.541

High

1251946

MTMR9
Myotubularin-related protein 9

1

19

High-throughput

0.541

High

1251964

MTMRA
Myotubularin-related protein 10

1

19

High-throughput

0.541

High

1251982

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

1

19

High-throughput

0.541

High

255651

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

9

High-throughput

0.536

High

292156

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

20

High-throughput

0.536

High

343970

HS74L
Heat shock 70 kDa protein 4L

1

20

High-throughput

0.536

High

727856

DNJA1
DnaJ homolog subfamily A member 1

1

20

High-throughput

0.536

High

995654

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.536

High

1251933

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.536

High

1251940

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

20

High-throughput

0.536

High

1024389

S25A3
Solute carrier family 25 member 3

1

18

High-throughput

0.500

High

1032491

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

18

High-throughput

0.500

High

1251951

NTPCR
Cancer-related nucleoside-triphosphatase

1

9

High-throughput

0.500

High

58731

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

20

High-throughput

0.494

High

124613

EYA2
Protein phosphatase EYA2

1

12

High-throughput

0.494

High

326725

DUS14
Dual specificity protein phosphatase 14

1

20

High-throughput

0.494

High

341602

EYA4
Protein phosphatase EYA4

1

18

High-throughput

0.494

High

593849

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

18

High-throughput

0.494

High

703950

DUS1
Dual specificity protein phosphatase 1

1

20

High-throughput

0.494

High

719235

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.494

High

719507

BKRB2
B2 bradykinin receptor

1

1

High-throughput

0.494

High

951725

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

20

High-throughput

0.494

High

1062379

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

19

High-throughput

0.494

High

1161866

DUS5
Dual specificity protein phosphatase 5

1

20

High-throughput

0.494

High

1163843

DUS6
Dual specificity protein phosphatase 6

1

20

High-throughput

0.494

High

1229391

DUS29
Dual specificity phosphatase 29

1

20

High-throughput

0.494

High

1251085

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

20

High-throughput

0.494

High

1251927

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

20

High-throughput

0.494

High

1251932

STYX
Serine/threonine/tyrosine-interacting protein

1

20

High-throughput

0.494

High

1251939

MTMR8
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8

1

19

High-throughput

0.494

High

1251942

PPM1M
Protein phosphatase 1M

1

14

High-throughput

0.494

High

1251949

DUS9
Dual specificity protein phosphatase 9

1

20

High-throughput

0.494

High

1251955

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

20

High-throughput

0.494

High

1251981

CC14A
Dual specificity protein phosphatase CDC14A

1

20

High-throughput

0.494

High

137747

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

7

High-throughput

0.489

High

415660

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.489

High

916285

TXTP
Tricarboxylate transport protein, mitochondrial

1

20

High-throughput

0.489

High

1145597

RCN1
Reticulocalbin-1

1

7

High-throughput

0.489

High

1251958

GHC1
Mitochondrial glutamate carrier 1

1

20

High-throughput

0.489

High

1251975

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

20

High-throughput

0.489

High

1251977

FBW1B
F-box/WD repeat-containing protein 11

1

9

High-throughput

0.489

High

64044

CNOT1
CCR4-NOT transcription complex subunit 1

1

2

High-throughput

0.479

High

126130

AP3B1
AP-3 complex subunit beta-1

1

20

High-throughput

0.479

High

221603

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

6

High-throughput

0.479

High

243664

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

12

High-throughput

0.479

High

244166

KIF5C
Kinesin heavy chain isoform 5C

1

20

High-throughput

0.479

High

271266

CPNE3
Copine-3

1

8

High-throughput

0.479

High

301090

RL1D1
Ribosomal L1 domain-containing protein 1

1

2

High-throughput

0.479

High

323883

SC31A
Protein transport protein Sec31A

1

20

High-throughput

0.479

High

344724

AP2A1
AP-2 complex subunit alpha-1

1

20

High-throughput

0.479

High

414063

P53
Cellular tumor antigen p53

1

12

High-throughput

0.479

High

426288

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

9

High-throughput

0.479

High

483589

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

6

High-throughput

0.479

High

612255

ARF4
ADP-ribosylation factor 4

1

17

High-throughput

0.479

High

637033

VATB2
V-type proton ATPase subunit B, brain isoform

1

5

High-throughput

0.479

High

800509

VATA
V-type proton ATPase catalytic subunit A

1

7

High-throughput

0.479

High

837234

ACTY
Beta-centractin

1

11

High-throughput

0.479

High

839779

EPS15
Epidermal growth factor receptor substrate 15

1

20

High-throughput

0.479

High

845321

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

20

High-throughput

0.479

High

868192

SYQ
Glutamine--tRNA ligase

1

5

High-throughput

0.479

High

898097

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

20

High-throughput

0.479

High

900381

FXR2
RNA-binding protein FXR2

1

12

High-throughput

0.479

High

957767

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

9

High-throughput

0.479

High

989020

AP2B1
AP-2 complex subunit beta

1

20

High-throughput

0.479

High

1008205

PRKDC
DNA-dependent protein kinase catalytic subunit

1

19

High-throughput

0.479

High

1056805

FMR1
Fragile X messenger ribonucleoprotein 1

1

12

High-throughput

0.479

High

1123682

DCTN1
Dynactin subunit 1

1

20

High-throughput

0.479

High

1123945

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

8

High-throughput

0.479

High

1130698

DIP2A
Disco-interacting protein 2 homolog A

1

17

High-throughput

0.479

High

1139631

SYK
Lysine--tRNA ligase

1

7

High-throughput

0.479

High

1140454

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

1145878

RBP1
RalA-binding protein 1

1

20

High-throughput

0.479

High

1241079

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

20

High-throughput

0.479

High

1248006

AFTIN
Aftiphilin

1

1

High-throughput

0.479

High

1251923

GCC2
GRIP and coiled-coil domain-containing protein 2

1

20

High-throughput

0.479

High

1251925

NUP93
Nuclear pore complex protein Nup93

1

6

High-throughput

0.479

High

1251930

NBEA
Neurobeachin

1

20

High-throughput

0.479

High

1251934

CNOT9
CCR4-NOT transcription complex subunit 9

1

2

High-throughput

0.479

High

1251935

SYAP1
Synapse-associated protein 1

1

5

High-throughput

0.479

High

1251936

EXOC4
Exocyst complex component 4

1

3

High-throughput

0.479

High

1251941

DDX27
Probable ATP-dependent RNA helicase DDX27

1

18

High-throughput

0.479

High

1251954

KLC2
Kinesin light chain 2

1

17

High-throughput

0.479

High

1251956

PDCL3
Phosducin-like protein 3

1

5

High-throughput

0.479

High

1251959

PPIP2
Proline-serine-threonine phosphatase-interacting protein 2

1

20

High-throughput

0.479

High

1251960

CNO10
CCR4-NOT transcription complex subunit 10

1

3

High-throughput

0.479

High

1251961

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

4

High-throughput

0.479

High

1251962

FANCI
Fanconi anemia group I protein

1

6

High-throughput

0.479

High

1251970

ANFY1
Rabankyrin-5

1

20

High-throughput

0.479

High

1251973

BAZ1B
Tyrosine-protein kinase BAZ1B

1

15

High-throughput

0.479

High

1251980

SYNRG
Synergin gamma

1

1

High-throughput

0.479

High

1251987

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

1251988

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

9

High-throughput

0.479

High

298191

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.458

High

403184

APOB
Apolipoprotein B-100

1

1

High-throughput

0.457

High

1112563

CUL1
Cullin-1

1

17

High-throughput

0.457

High

1251918

ACD11
Acyl-CoA dehydrogenase family member 11

1

5

High-throughput

0.457

High

1251920

FBX11
F-box only protein 11

1

1

High-throughput

0.457

High

1251971

DIC
Mitochondrial dicarboxylate carrier

1

20

High-throughput

0.457

High

1251984

FBW1A
F-box/WD repeat-containing protein 1A

1

11

High-throughput

0.457

High

257129

CCD22
Coiled-coil domain-containing protein 22

1

20

High-throughput

0.437

High

261917

PP1RB
E3 ubiquitin-protein ligase PPP1R11

1

1

High-throughput

0.437

High

361802

PNPH
Purine nucleoside phosphorylase

1

2

High-throughput

0.437

High

566721

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.437

High

834125

IPP2
Protein phosphatase inhibitor 2

1

1

High-throughput

0.437

High

878488

PAXI
Paxillin

1

20

High-throughput

0.437

High

895586

SERPH
Serpin H1

1

12

High-throughput

0.437

High

976746

ERF1
Eukaryotic peptide chain release factor subunit 1

1

3

High-throughput

0.437

High

1011822

RT05
Small ribosomal subunit protein uS5m

1

6

High-throughput

0.437

High

1063363

GOGA2
Golgin subfamily A member 2

1

16

High-throughput

0.437

High

1083261

AP1B1
AP-1 complex subunit beta-1

1

20

High-throughput

0.437

High

1085181

WASC5
WASH complex subunit 5

1

3

High-throughput

0.437

High

1091776

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

11

High-throughput

0.437

High

1116511

FHL3
Four and a half LIM domains protein 3

1

20

High-throughput

0.437

High

1137796

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1144835

RABE1
Rab GTPase-binding effector protein 1

1

13

High-throughput

0.437

High

1148853

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

20

High-throughput

0.437

High

1150919

TRIPB
Thyroid receptor-interacting protein 11

1

20

High-throughput

0.437

High

1178936

WASC4
WASH complex subunit 4

1

3

High-throughput

0.437

High

1191585

RABL6
Rab-like protein 6

1

2

High-throughput

0.437

High

1225362

WAC2A
WASH complex subunit 2A

1

3

High-throughput

0.437

High

1225932

F91A1
Protein FAM91A1

1

2

High-throughput

0.437

High

1233126

RGPA1
Ral GTPase-activating protein subunit alpha-1

1

6

High-throughput

0.437

High

1250811

RFIP1
Rab11 family-interacting protein 1

1

20

High-throughput

0.437

High

1251917

RINL
Ras and Rab interactor-like protein

1

10

High-throughput

0.437

High

1251919

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

High-throughput

0.437

High

1251921

TPPC5
Trafficking protein particle complex subunit 5

1

1

High-throughput

0.437

High

1251922

AHNK2
Protein AHNAK2

1

16

High-throughput

0.437

High

1251928

ENAH
Protein enabled homolog

1

19

High-throughput

0.437

High

1251931

NEDD1
Protein NEDD1

1

12

High-throughput

0.437

High

1251938

AP2M1
AP-2 complex subunit mu

1

12

High-throughput

0.437

High

1251944

RBM14
RNA-binding protein 14

1

17

High-throughput

0.437

High

1251945

TPPC9
Trafficking protein particle complex subunit 9

1

3

High-throughput

0.437

High

1251947

NEB2
Neurabin-2

1

20

High-throughput

0.437

High

1251950

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

14

High-throughput

0.437

High

1251952

RFIP5
Rab11 family-interacting protein 5

1

19

High-throughput

0.437

High

1251953

EGLN1
Egl nine homolog 1

1

5

High-throughput

0.437

High

1251965

ARP10
Actin-related protein 10

1

9

High-throughput

0.437

High

1251966

GGA3
ADP-ribosylation factor-binding protein GGA3

1

20

High-throughput

0.437

High

1251969

F135A
Protein FAM135A

1

6

High-throughput

0.437

High

1251974

HOOK1
Protein Hook homolog 1

1

20

High-throughput

0.437

High

1251976

DCTN4
Dynactin subunit 4

1

1

High-throughput

0.437

High

1251978

MRT4
mRNA turnover protein 4 homolog

1

5

High-throughput

0.437

High

1251979

NEB1
Neurabin-1

1

20

High-throughput

0.437

High

1251983

TPPC4
Trafficking protein particle complex subunit 4

1

1

High-throughput

0.437

High

1251985

SBDS
Ribosome maturation protein SBDS

1

2

High-throughput

0.437

High

1251986

RBGP1
Rab GTPase-activating protein 1

1

20

High-throughput

0.437

High

1251943

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.316

High

903716

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.279

Low

133365

DCTN6
Dynactin subunit 6

1

0

High-throughput

0.249

Low

874040

TPC10
Trafficking protein particle complex subunit 10

1

0

High-throughput

0.249

Low

1251957

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.249

Low

1251968

RELCH
RAB11-binding protein RELCH

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025