HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29656893, 12611903
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BRCT~BRCT_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006974 - DNA damage response
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 777
+	Hs
		1019103 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		801335 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		1056981 MDC1_HUMAN (1-2089): 0: 665: 100.00		TNKS2_HUMAN (396-760): 1.04e-52: 200: 18.97
+	Hs
		310053 MDC1_HUMAN (1-2089): 0: 665: 100.00		TNKS1_HUMAN (364-552): 9.86e-28: 122: 23.98
+	Hs
		1305982 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Mm
		103608 ANK2_MOUSE (231-1876): 4.19e-49: 196: 11.28		ANK3_MOUSE (104-622): 8.12e-77: 273: 14.69
+	Hs
		1167351 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		BCOR_HUMAN (152-543): 1.16e-44: 176: 23.93
+	Hs
		62456 A6NEM2_HUMAN (191-1876): 5.64e-55: 215: 7.76		MPP8_HUMAN (119-549): 1.23e-51: 195: 15.51
+	Dm
		65570 FUTSC_DROME (102-1944): 3.69e-41: 170: 8.41		A8JNM5_DROME (291-673): 1.73e-50: 194: 13.97
+	Hs
		862028 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		DAPK1_HUMAN (194-574): 1.25e-79: 281: 15.62
+	Hs
		166985 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		ANR28_HUMAN (221-515): 1.02e-47: 185: 17.16
+	Hs
		257726 PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07		ANR17_HUMAN (177-599): 3.04e-64: 236: 15.72
+	Hs
		166913 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		ANR28_HUMAN (221-515): 1.02e-47: 185: 17.16
+	Hs
		556716 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		ANK1_HUMAN (453-703): 3.76e-22: 105: 13.44
+	Hs
		1295178 ZN469_HUMAN (108-1444): 1.39e-21: 105: 8.20		Q9H4D1_HUMAN (216-431): 1.1e-17: 90: 8.04
+	Hs
		883603 ZN469_HUMAN (108-1444): 1.39e-21: 105: 8.20		RIPK4_HUMAN (216-431): 2.07e-17: 89.2: 7.59
+	Hs
		965154 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		Q9H4D1_HUMAN (216-431): 1.1e-17: 90: 8.04
+	Hs
		883487 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		RIPK4_HUMAN (216-431): 2.07e-17: 89.2: 7.59