HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: CHAP1 (Q96JM3)
Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828)
Gene: CHAMP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22990118
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016604 - nuclear body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2089 Hs			1 812
+	Hs
		1056827 MDC1_HUMAN (1-2089): 0: 665: 100.00		MDC1_HUMAN (135-725): 6.26e-13: 74.9: 9.98
+	Hs
		1056910 MDC1_HUMAN (1-2089): 0: 665: 100.00		CBP_HUMAN (165-566): 3.23e-11: 69.6: 17.59
+	Hs
		1056876 MDC1_HUMAN (1-2089): 0: 665: 100.00		MICA3_HUMAN (182-723): 2.31e-10: 66.9: 11.44
+	Hs
		801310 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		CHAP1_HUMAN (1-812): 1.59e-115: 371: 100.00
+	Hs
		741039 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		ZEB1_HUMAN (361-798): 4.28e-41: 165: 16.25
+	Hs
		801096 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		IF4G1_HUMAN (112-705): 1.45e-24: 112: 11.69
+	Hs
		1018956 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		MDC1_HUMAN (135-725): 6.26e-13: 74.9: 9.98
+	Hs
		1019050 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CBP_HUMAN (165-566): 3.23e-11: 69.6: 17.59
+	Hs
		1019194 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CABIN_HUMAN (174-479): 6.78e-11: 68.5: 17.65
+	Hs
		1270850 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		CBP_HUMAN (165-566): 3.23e-11: 69.6: 17.59
+	Hs
		801143 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		MDC1_HUMAN (135-725): 6.26e-13: 74.9: 9.98
+	Hs
		152608 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		KMT2D_HUMAN (104-630): 1.61e-09: 64.2: 19.02
+	Hs
		1056872 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		MDC1_HUMAN (135-725): 6.26e-13: 74.9: 9.98
+	Mm
		1157867 PAXI1_MOUSE (1840-2081): 5.99e-54: 209: 29.80		KMT2C_MOUSE (52-727): 1.37e-11: 70.7: 8.88
+	Hs
		1173188 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2C_HUMAN (271-696): 8.4e-10: 64.8: 11.45
+	Hs
		152660 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2D_HUMAN (104-630): 1.61e-09: 64.2: 19.02
+	Mm
		1157866 PAXI1_MOUSE (1840-2081): 5.99e-54: 209: 29.80		KMT2D_MOUSE (70-738): 5.61e-09: 62.2: 10.15
+	Hs
		1137771 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		OBSCN_HUMAN (136-679): 3.63e-21: 102: 15.54
+	Hs
		1264771 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		TITIN_HUMAN (75-712): 9.93e-10: 64.7: 11.98
+	Hs
		311825 TACC2_HUMAN (151-1928): 1.23e-24: 115: 9.64		CBP_HUMAN (165-566): 3.23e-11: 69.6: 17.59