Protein: TRIM3
Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)

Gene: TRIM3
Organism: Homo sapiens
Interactions: 75
UniProt ID: O75382

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005794 - Golgi apparatus
GO:0007399 - nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

279069

TRIM2
Tripartite motif-containing protein 2

5

17

Small-scale

0.924

High

279012

TRIM3
Tripartite motif-containing protein 3

5

16

Small-scale

0.922

High

279031

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.891

High

224561

ACTN4
Alpha-actinin-4

3

9

Small-scale

0.854

High

279020

RO52
E3 ubiquitin-protein ligase TRIM21

2

17

High-throughput

0.783

High

279059

LNX1
E3 ubiquitin-protein ligase LNX

2

11

High-throughput

0.783

High

279067

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

High-throughput

0.783

High

279038

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.778

High

279076

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

20

Small-scale

0.767

High

279039

UBC9
SUMO-conjugating enzyme UBC9

2

20

Small-scale

0.757

High

279071

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

2

20

High-throughput

0.700

High

279036

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

High-throughput

0.698

High

279050

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

279028

KC1E
Casein kinase I isoform epsilon

4

8

Small-scale

0.692

High

279033

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

Small-scale

0.647

High

279037

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

279064

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

Small-scale

0.647

High

279015

ESR1
Estrogen receptor

2

20

Small-scale

0.624

High

240277

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.618

High

279052

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.618

High

279048

TEAD2
Transcriptional enhancer factor TEF-4

3

4

High-throughput

0.607

High

279027

KC1D
Casein kinase I isoform delta

2

6

High-throughput

0.606

High

279051

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

4

High-throughput

0.606

High

279057

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

2

20

High-throughput

0.606

High

279068

KCTD7
BTB/POZ domain-containing protein KCTD7

2

11

High-throughput

0.606

High

279075

MYO5B
Unconventional myosin-Vb

2

6

High-throughput

0.606

High

279053

Q7KZS0
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.594

High

142463

IMA3
Importin subunit alpha-3

2

8

Small-scale

0.584

High

279044

CUL3
Cullin-3

2

18

Small-scale

0.584

High

279046

BECN1
Beclin-1

2

5

Small-scale

0.584

High

279077

MYO5A
Unconventional myosin-Va

2

7

Small-scale

0.584

High

279017

ARLY
Argininosuccinate lyase

2

0

High-throughput

0.580

High

279072

ROP1A
Ropporin-1A

2

0

High-throughput

0.580

High

279019

TAU
Microtubule-associated protein tau

2

15

High-throughput

0.571

High

279024

TEAD1
Transcriptional enhancer factor TEF-1

2

4

High-throughput

0.553

High

269427

KI21B
Kinesin-like protein KIF21B

1

10

Small-scale

0.552

High

279022

DNMT1
DNA

1

6

High-throughput

0.541

High

279029

FXR1
RNA-binding protein FXR1

1

8

High-throughput

0.541

High

279030

FXR2
RNA-binding protein FXR2

1

8

High-throughput

0.541

High

279062

TSC1
Hamartin

1

15

High-throughput

0.541

High

279045

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.536

High

279065

ARRD3
Arrestin domain-containing protein 3

1

3

High-throughput

0.536

High

279025

CDN1A
Cyclin-dependent kinase inhibitor 1

1

6

Small-scale

0.501

High

279049

EMC4
ER membrane protein complex subunit 4

1

1

High-throughput

0.489

High

279021

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

12

High-throughput

0.481

High

169351

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

9

Small-scale

0.479

High

191195

TLR3
Toll-like receptor 3

1

2

Small-scale

0.479

High

279016

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

13

High-throughput

0.479

High

279018

P53
Cellular tumor antigen p53

1

15

Small-scale

0.479

High

279040

VIGLN
Vigilin

1

15

High-throughput

0.479

High

279041

RL6
Large ribosomal subunit protein eL6

1

2

Small-scale

0.479

High

279042

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

279043

PABP4
Polyadenylate-binding protein 4

1

9

Small-scale

0.479

High

279047

IMB1
Importin subunit beta-1

1

5

Small-scale

0.479

High

279055

SERB1
SERPINE1 mRNA-binding protein 1

1

1

Small-scale

0.479

High

279063

DDX17
Probable ATP-dependent RNA helicase DDX17

1

6

Small-scale

0.479

High

279070

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

279073

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.479

High

279074

SAE1
SUMO-activating enzyme subunit 1

1

4

Small-scale

0.479

High

279034

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

279054

ZN276
Zinc finger protein 276

1

20

High-throughput

0.445

High

279066

DTBP1
Dysbindin

1

4

High-throughput

0.445

High

104955

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

279013

PRP6
Pre-mRNA-processing factor 6

1

3

Small-scale

0.437

High

279023

U2AF2
Splicing factor U2AF 65 kDa subunit

1

12

Small-scale

0.437

High

279026

NOTC1
Neurogenic locus notch homolog protein 1

1

9

Small-scale

0.437

High

279035

FOXA1
Hepatocyte nuclear factor 3-alpha

1

7

High-throughput

0.437

High

279061

MIPT3
TRAF3-interacting protein 1

1

1

High-throughput

0.417

High

279058

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

279032

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.279

Low

279056

TMIE
Transmembrane inner ear expressed protein

1

0

High-throughput

0.279

Low

279014

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

87571

RBRP
Putative RNA-binding regulatory peptide

1

0

High-throughput

0.232

Low

279060

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025