HitPredict

Interactor 1: ARI5B (Q14865)
AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2)
Gene: ARID5B

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1188 Hs			1 488
+	Hs
		1038383 ARI5B_HUMAN (1-1188): 0: 1901: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		782369 KDM5C_HUMAN (238-549): 1.82e-70: 261: 18.21		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270501 KDM5B_HUMAN (243-535): 7.32e-62: 234: 17.82		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		666546 KDM5A_HUMAN (240-509): 9.16e-51: 199: 18.15		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		782341 KDM5C_HUMAN (238-549): 1.82e-70: 261: 18.21		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140293 KDM5B_MOUSE (243-528): 2.51e-61: 232: 16.89		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1038782 KDM5B_HUMAN (243-535): 7.32e-62: 234: 17.82		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		57763 ARI1A_MOUSE (307-567): 6.25e-39: 161: 15.65		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Dm
		1276545 KDM5_DROME (231-546): 1.22e-54: 211: 17.42		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		1117679 ARI4B_HUMAN (323-536): 9.31e-37: 153: 24.89		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270349 JARD2_HUMAN (257-462): 9.34e-37: 153: 14.16		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		666529 KDM5A_HUMAN (240-509): 9.16e-51: 199: 18.15		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		57753 ARI1A_MOUSE (307-567): 6.25e-39: 161: 15.65		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		146213 ARI1A_HUMAN (307-567): 1.84e-39: 162: 15.65		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038432 ARI4B_HUMAN (323-536): 9.31e-37: 153: 24.89		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Sc
		693059 ECM5_YEAST (254-599): 7.64e-49: 192: 15.13		RPD3_YEAST (5-422): 0: 577: 60.95
+	Mm
		93520 ARI1B_MOUSE (318-568): 5.48e-43: 174: 15.54		Q9JM08_MOUSE (10-431): 0: 568: 58.02
+	Mm
		57887 ARI4B_MOUSE (323-540): 5.78e-37: 154: 23.87		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Hs
		1260198 KDM5B_HUMAN (243-535): 7.32e-62: 234: 17.82		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37
+	Hs
		978219 ARI5A_HUMAN (324-594): 1.05e-52: 197: 35.02		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37