Protein: MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)

Gene: MCL1
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q07820

Gene Ontology (top 5):
GO:0001709 - cell fate determination
GO:0001836 - release of cytochrome c from mitochondria
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

219622

B2L11
Bcl-2-like protein 11

32

16

Small-scale

0.992

High

1060264

BAK
Bcl-2 homologous antagonist/killer

26

18

Small-scale

0.991

High

1060259

APR
Phorbol-12-myristate-13-acetate-induced protein 1

22

7

Small-scale

0.988

High

1060080

BAX
Apoptosis regulator BAX

13

16

Small-scale

0.980

High

939617

BID
BH3-interacting domain death agonist

7

10

Small-scale

0.970

High

1060292

BBC3
Bcl-2-binding component 3, isoforms 1/2

5

7

Small-scale

0.908

High

1060286

BMF
Bcl-2-modifying factor

5

7

Small-scale

0.892

High

1060251

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

18

Small-scale

0.821

High

332399

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

2

1

Small-scale

0.808

High

1060260

BECN1
Beclin-1

2

7

Small-scale

0.776

High

1060273

HUWE1
E3 ubiquitin-protein ligase HUWE1

22

3

Small-scale

0.768

High

1060278

BAD
Bcl2-associated agonist of cell death

2

8

Small-scale

0.767

High

1060280

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

9

2

Small-scale

0.756

High

1060288

BBC3B
Bcl-2-binding component 3, isoforms 3/4

10

5

Small-scale

0.752

High

1060281

FBXW7
F-box/WD repeat-containing protein 7

11

5

Small-scale

0.752

High

1060156

B2CL1
Bcl-2-like protein 1

2

16

Small-scale

0.737

High

413698

P53
Cellular tumor antigen p53

2

9

Small-scale

0.727

High

1060290

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

2

Small-scale

0.724

High

1060283

TRI11
E3 ubiquitin-protein ligase TRIM11

5

3

Small-scale

0.719

High

1060279

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

4

2

Small-scale

0.692

High

225571

AAKB2
5'-AMP-activated protein kinase subunit beta-2

4

1

High-throughput

0.691

High

1060314

AAKB1
5'-AMP-activated protein kinase subunit beta-1

4

1

High-throughput

0.691

High

1060304

SEPT9
Septin-9

4

1

High-throughput

0.683

High

1060303

STAR9
StAR-related lipid transfer protein 9

3

1

High-throughput

0.667

High

1060254

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

4

0

High-throughput

0.661

High

1060295

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

1

Small-scale

0.647

High

1060270

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

3

1

Small-scale

0.640

High

551003

PCNA
Proliferating cell nuclear antigen

3

0

Small-scale

0.640

High

1060255

BIK
Bcl-2-interacting killer

3

5

Small-scale

0.639

High

1060291

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

1

High-throughput

0.628

High

1060313

FBW1A
F-box/WD repeat-containing protein 1A

2

4

Small-scale

0.624

High

930297

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

3

0

High-throughput

0.622

High

1060310

BOK
Bcl-2-related ovarian killer protein

1

18

Small-scale

0.621

High

241491

PRKN
E3 ubiquitin-protein ligase parkin

1

7

Small-scale

0.618

High

289254

SPB7
Serpin B7

2

3

High-throughput

0.611

High

635583

FILA
Filaggrin

2

1

High-throughput

0.611

High

662777

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

2

1

High-throughput

0.611

High

1060296

KCNF1
Voltage-gated potassium channel regulatory subunit KCNF1

2

1

High-throughput

0.606

High

251211

RNBP6
Ran-binding protein 6

2

0

High-throughput

0.602

High

67165

ZAR1L
Protein ZAR1-like

2

1

High-throughput

0.601

High

1060252

EP300
Histone acetyltransferase p300

2

5

Small-scale

0.595

High

522079

BCL2
Apoptosis regulator Bcl-2

1

16

Small-scale

0.590

High

1060267

APRV1
Retroviral-like aspartic protease 1

2

0

High-throughput

0.585

High

840044

CASP3
Caspase-3

2

6

Small-scale

0.585

High

761650

HSP74
Heat shock 70 kDa protein 4

2

2

Small-scale

0.584

High

992149

SKP1
S-phase kinase-associated protein 1

2

1

Small-scale

0.584

High

1060258

CUL1
Cullin-1

2

2

Small-scale

0.584

High

1060262

JOS1
Josephin-1

2

1

Small-scale

0.584

High

891487

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.578

High

848478

MAGA8
Melanoma-associated antigen 8

2

0

High-throughput

0.576

High

667802

CDK2
Cyclin-dependent kinase 2

1

5

Small-scale

0.561

High

1060253

CDC20
Cell division cycle protein 20 homolog

1

3

Small-scale

0.561

High

1060257

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.561

High

1060301

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

2

Small-scale

0.561

High

1060315

TRAF6
TNF receptor-associated factor 6

1

4

Small-scale

0.561

High

858580

IEX1
Radiation-inducible immediate-early gene IEX-1

2

0

Small-scale

0.551

High

923382

MK10
Mitogen-activated protein kinase 10

1

13

Small-scale

0.550

High

126018

HRK
Activator of apoptosis harakiri

2

4

Small-scale

0.545

High

991503

DYL1
Dynein light chain 1, cytoplasmic

1

4

High-throughput

0.536

High

1060284

DYL2
Dynein light chain 2, cytoplasmic

1

4

High-throughput

0.536

High

963558

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

Small-scale

0.529

High

1060307

FBW1B
F-box/WD repeat-containing protein 11

1

4

Small-scale

0.527

High

423639

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

946483

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.513

High

1060269

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.513

High

1060285

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

1060289

GBP5
Guanylate-binding protein 5

1

0

High-throughput

0.513

High

1060312

SC5A6
Sodium-dependent multivitamin transporter

1

0

High-throughput

0.513

High

728194

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

High-throughput

0.506

High

640865

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

8

Small-scale

0.501

High

703551

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.501

High

891135

GSK3A
Glycogen synthase kinase-3 alpha

1

9

Small-scale

0.501

High

1060265

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.501

High

1060274

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

2

Small-scale

0.501

High

1060282

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.501

High

1060272

BOP
Protein Bop

1

6

Small-scale

0.500

High

1041022

CAV1
Caveolin-1

1

0

Small-scale

0.493

High

697087

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.480

High

1060294

UBXN6
UBX domain-containing protein 6

1

0

Small-scale

0.480

High

157280

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

163092

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

317631

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.479

High

336653

BAG4
BAG family molecular chaperone regulator 4

1

5

Small-scale

0.479

High

347663

BAG3
BAG family molecular chaperone regulator 3

1

5

Small-scale

0.479

High

373899

RASN
GTPase NRas

1

6

High-throughput

0.479

High

374545

RASH
GTPase HRas

1

6

High-throughput

0.479

High

375449

RASK
GTPase KRas

1

6

High-throughput

0.479

High

410795

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

Small-scale

0.479

High

443332

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.479

High

463477

LYN
Tyrosine-protein kinase Lyn

1

3

Small-scale

0.479

High

558069

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

567385

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.479

High

1037128

H11
Histone H1.1

1

1

Small-scale

0.479

High

1060256

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

1060271

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1060277

KAT2B
Histone acetyltransferase KAT2B

1

1

Small-scale

0.479

High

1060293

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

Small-scale

0.479

High

1060309

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

293608

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

537034

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

785822

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

1060261

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1060287

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1060298

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1060300

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.458

High

1060305

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1060308

FBX4
F-box only protein 4

1

0

Small-scale

0.458

High

408832

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.445

High

518742

GRAB
Granzyme B

1

1

Small-scale

0.445

High

853662

MK08
Mitogen-activated protein kinase 8

1

13

Small-scale

0.445

High

853781

MK09
Mitogen-activated protein kinase 9

1

13

Small-scale

0.445

High

952773

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.445

High

1060316

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.445

High

895540

SERPH
Serpin H1

1

2

Small-scale

0.437

High

1060276

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

339073

NADK
NAD kinase

1

0

High-throughput

0.426

High

559939

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

Small-scale

0.426

High

1060299

PAAT
ATPase PAAT

1

0

High-throughput

0.426

High

1060306

ZPI
Protein Z-dependent protease inhibitor

1

2

High-throughput

0.407

High

669188

EDNRA
Endothelin-1 receptor

3

0

High-throughput

0.347

High

1060302

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

0

High-throughput

0.328

High

1060263

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.318

High

1060311

STX8
Syntaxin-8

2

0

High-throughput

0.316

High

466888

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.282

High

1060275

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

1

0

High-throughput

0.279

Low

1060297

TMPS5
Transmembrane protease serine 5

1

0

High-throughput

0.279

Low

1060268

OTUD1
OTU domain-containing protein 1

1

0

Small-scale

0.249

Low

1060266

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025