HitPredict

Interactor 1: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Interactor 2: CBX8 (Q9HC52)
Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)
Gene: CBX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	16169070
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1291 Hs			1 389
+	Hs
		1065757 SETB1_HUMAN (1-1291): 0: 1373: 100.00		CDYL_HUMAN (2-312): 1.24e-66: 223: 14.65
+	Hs
		1065768 SETB1_HUMAN (1-1291): 0: 1373: 100.00		CDY2_HUMAN (6-312): 1.45e-54: 190: 13.76
+	Hs
		1065698 SETB1_HUMAN (1-1291): 0: 1373: 100.00		MPP8_HUMAN (6-356): 2.27e-52: 188: 18.85
+	Hs
		203690 SETB1_HUMAN (1-1291): 0: 1373: 100.00		SUV91_HUMAN (11-102): 9.92e-27: 112: 25.25
+	Hs
		1027006 SETB1_HUMAN (1-1291): 0: 1373: 100.00		CBX3_HUMAN (9-144): 1.3e-26: 106: 25.74
+	Hs
		800384 SETB1_HUMAN (1-1291): 0: 1373: 100.00		CBX5_HUMAN (11-144): 1.06e-25: 104: 25.00
+	Hs
		949786 SETB1_HUMAN (1-1291): 0: 1373: 100.00		CBX1_HUMAN (17-122): 3.63e-23: 97.5: 28.97
+	Hs
		123140 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		1334148 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		CDY2_HUMAN (6-312): 1.45e-54: 190: 13.76
+	Hs
		1304468 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		MPP8_HUMAN (6-356): 2.27e-52: 188: 18.85
+	Hs
		203794 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		SUV91_HUMAN (11-102): 9.92e-27: 112: 25.25
+	Hs
		1331975 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		SUV92_HUMAN (9-103): 2.94e-26: 110: 22.43
+	Hs
		1027268 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		CBX3_HUMAN (9-144): 1.3e-26: 106: 25.74
+	Hs
		800530 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		CBX5_HUMAN (11-144): 1.06e-25: 104: 25.00
+	Hs
		949889 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		CBX1_HUMAN (17-122): 3.63e-23: 97.5: 28.97
+	Hs
		203597 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		SUV91_HUMAN (11-102): 9.92e-27: 112: 25.25
+	Mm
		1125433 EHMT1_MOUSE (995-1287): 2.13e-66: 248: 21.84		Q9DCC5_MOUSE (9-144): 1.3e-26: 106: 25.74
+	Hs
		203638 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		CBX5_HUMAN (11-144): 1.06e-25: 104: 25.00
+	Mm
		949933 EHMT1_MOUSE (995-1287): 2.13e-66: 248: 21.84		CBX1_MOUSE (17-122): 3.63e-23: 97.5: 28.97
+	Hs
		203662 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		CBX1_HUMAN (17-122): 3.63e-23: 97.5: 28.97