Protein: RPGF5
Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)

Gene: RPGF5, RAPGEF5
Organism: Homo sapiens
Interactions: 34
UniProt ID: Q92565

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005886 - plasma membrane
GO:0007264 - small GTPase-mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982111

RAP1A
Ras-related protein Rap-1A

2

20

Small-scale

0.778

High

725426

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

0

High-throughput

0.770

High

165131

RASM
Ras-related protein M-Ras

1

20

Small-scale

0.724

High

518620

RAP2A
Ras-related protein Rap-2a

1

20

Small-scale

0.647

High

507297

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

5

High-throughput

0.628

High

592951

ANK1
Ankyrin-1

2

3

High-throughput

0.628

High

651689

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

2

7

High-throughput

0.628

High

839167

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

2

2

High-throughput

0.628

High

1030674

ANK2
Ankyrin-2

2

3

High-throughput

0.628

High

1091440

ANK3
Ankyrin-3

2

3

High-throughput

0.628

High

1131693

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

2

4

High-throughput

0.628

High

1143213

PLEC
Plectin

2

2

High-throughput

0.628

High

1153205

HERC1
Probable E3 ubiquitin-protein ligase HERC1

2

4

High-throughput

0.628

High

1191451

GRDN
Girdin

2

2

High-throughput

0.628

High

1364795

WNK1
Serine/threonine-protein kinase WNK1

2

6

High-throughput

0.628

High

1246898

RICTR
Rapamycin-insensitive companion of mTOR

2

0

High-throughput

0.602

High

1292175

LIPB1
Liprin-beta-1

2

0

High-throughput

0.602

High

318209

DDHD2
Triacylglycerol hydrolase DDHD2

2

2

High-throughput

0.574

High

1103720

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

2

High-throughput

0.574

High

1364796

TBB1
Tubulin beta-1 chain

2

1

High-throughput

0.574

High

1109637

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

5

High-throughput

0.536

High

1125373

FLNC
Filamin-C

1

3

High-throughput

0.536

High

1346605

VANG1
Vang-like protein 1

1

0

High-throughput

0.518

High

1032632

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

0

High-throughput

0.513

High

1202107

HS904
Putative heat shock protein HSP 90-alpha A4

2

2

High-throughput

0.504

High

594064

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.479

High

619085

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

5

Small-scale

0.479

High

839057

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

Small-scale

0.479

High

566776

PDIA4
Protein disulfide-isomerase A4

1

2

High-throughput

0.470

High

1364798

KCND3
A-type voltage-gated potassium channel KCND3

1

0

Small-scale

0.458

High

1364797

ZNHI2
Zinc finger HIT domain-containing protein 2

2

0

High-throughput

0.328

High

505633

TM253
Transmembrane protein 253

1

0

High-throughput

0.282

High

1206603

PLAC9
Placenta-specific protein 9

1

0

High-throughput

0.282

High

1226482

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025