Protein: RPGF2
Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)

Gene: RPGF2, RAPGEF2
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9Y4G8

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001568 - blood vessel development
GO:0001764 - neuron migration
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1401146

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

3

9

Small-scale

0.830

High

982144

RAP1A
Ras-related protein Rap-1A

2

20

Small-scale

0.799

High

1091743

GNDS
Ral guanine nucleotide dissociation stimulator

1

3

Small-scale

0.680

High

861855

NEDD4
E3 ubiquitin-protein ligase NEDD4

3

4

Small-scale

0.667

High

862582

YAP1
Transcriptional coactivator YAP1

3

12

Small-scale

0.667

High

1288695

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

10

Small-scale

0.665

High

1353184

RPGF6
Rap guanine nucleotide exchange factor 6

1

3

High-throughput

0.665

High

375038

RASH
GTPase HRas

1

20

Small-scale

0.647

High

959452

RAP2B
Ras-related protein Rap-2b

1

20

Small-scale

0.647

High

1490649

FBW1A
F-box/WD repeat-containing protein 1A

3

3

Small-scale

0.640

High

967066

1433G
14-3-3 protein gamma

2

20

High-throughput

0.628

High

972173

1433E
14-3-3 protein epsilon

2

4

High-throughput

0.628

High

1049945

1433F
14-3-3 protein eta

2

20

High-throughput

0.628

High

1119803

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

10

High-throughput

0.621

High

332465

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

3

High-throughput

0.618

High

1058962

ZO1
Tight junction protein 1

1

6

High-throughput

0.618

High

1090208

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

9

High-throughput

0.618

High

1215984

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

9

High-throughput

0.618

High

1361947

TITIN
Titin

1

4

High-throughput

0.618

High

1396879

SNX27
Sorting nexin-27

1

13

High-throughput

0.618

High

990914

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1461019

FBW1B
F-box/WD repeat-containing protein 11

2

3

High-throughput

0.584

High

1453191

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.559

High

750027

KINH
Kinesin-1 heavy chain

1

3

High-throughput

0.541

High

1087042

KIF5A
Kinesin heavy chain isoform 5A

1

3

High-throughput

0.541

High

1116170

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.541

High

691577

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

730393

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

835780

KPCI
Protein kinase C iota type

1

8

High-throughput

0.536

High

844130

HD
Huntingtin

1

1

High-throughput

0.536

High

1022816

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

High-throughput

0.536

High

1396705

LLR1
Leucine-rich repeat protein 1

1

2

High-throughput

0.536

High

1430105

RGAP1
Rac GTPase-activating protein 1

1

3

High-throughput

0.536

High

1491114

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.518

High

1127997

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.513

High

1131252

MESD
LRP chaperone MESD

1

0

High-throughput

0.513

High

1231298

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.513

High

1394947

VPS50
Syndetin

1

0

High-throughput

0.513

High

1404295

SEC62
Translocation protein SEC62

1

0

High-throughput

0.513

High

1419191

ANO3
Anoctamin-3

1

0

High-throughput

0.513

High

1400056

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

4

Small-scale

0.501

High

64444

BDP1
Transcription factor TFIIIB component B'' homolog

1

8

High-throughput

0.489

High

848755

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

1396158

Z512B
Zinc finger protein 512B

1

4

High-throughput

0.489

High

1436750

SP14L
Nuclear body protein SP140-like protein

1

3

High-throughput

0.489

High

62069

WDR91
WD repeat-containing protein 91

1

3

High-throughput

0.479

High

173604

XPO1
Exportin-1

1

2

High-throughput

0.479

High

239261

ZNRD2
Protein ZNRD2

1

2

High-throughput

0.479

High

508890

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

690436

STOM
Stomatin

1

1

High-throughput

0.479

High

705851

AMPL
Cytosol aminopeptidase

1

1

High-throughput

0.479

High

907639

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

913625

KIF11
Kinesin-like protein KIF11

1

3

High-throughput

0.479

High

971351

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1071202

ARL16
ADP-ribosylation factor-like protein 16

1

1

High-throughput

0.479

High

1125425

FLNC
Filamin-C

1

3

High-throughput

0.479

High

1143319

PLEC
Plectin

1

2

High-throughput

0.479

High

1328702

KCD17
BTB/POZ domain-containing protein KCTD17

1

5

High-throughput

0.479

High

1402083

HMCN1
Hemicentin-1

1

4

High-throughput

0.479

High

1406099

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

1439314

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.479

High

1452143

KCTD5
BTB/POZ domain-containing protein KCTD5

1

5

High-throughput

0.479

High

595658

H15
Histone H1.5

1

1

High-throughput

0.470

High

522310

OSTP
Osteopontin

1

0

Small-scale

0.460

High

386398

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

980600

H4
Histone H4

1

0

High-throughput

0.458

High

1040246

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.458

High

1108314

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1270453

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

1339068

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.458

High

109338

G5E9A6
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.445

High

106915

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1242065

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.437

High

1362042

CTTB2
Cortactin-binding protein 2

1

7

High-throughput

0.437

High

1429960

BRD8
Bromodomain-containing protein 8

1

5

High-throughput

0.437

High

91533

C9J1X0
WD repeat-containing protein 91

1

3

High-throughput

0.407

High

397819

ATP8
ATP synthase F(0) complex subunit 8

1

0

High-throughput

0.282

High

215761

ERI3
ERI1 exoribonuclease 3

1

0

High-throughput

0.279

Low

634202

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

1332166

SR1IP
Protein SREK1IP1

1

0

High-throughput

0.279

Low

1394495

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.279

Low

1460573

TRM6
tRNA

1

0

High-throughput

0.279

Low

1162093

H31T
Histone H3.1t

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025