HitPredict

Interactor 1: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	21900206
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 347
+	Hs
		1066027 ARHG6_HUMAN (1-776): 0: 621: 100.00		RHG44_HUMAN (6-252): 4.15e-52: 186: 22.10
+	Hs
		924563 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		1217523 TIAM2_HUMAN (120-772): 1.93e-88: 307: 14.05		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		1078900 ITSN1_HUMAN (18-575): 4.42e-86: 300: 15.88		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		1307421 ITSN2_HUMAN (17-575): 4.43e-83: 291: 16.67		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Hs
		924938 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		855774 FGD1_MOUSE (200-698): 9.43e-82: 282: 17.55		SRC8_MOUSE (7-343): 2.48e-52: 183: 13.24
+	Hs
		50588 PKHG3_HUMAN (234-727): 9.14e-82: 286: 19.80		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		69770 B1ALK7_HUMAN (155-769): 5.57e-124: 389: 50.77		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		548677 VAV_HUMAN (1-746): 1.59e-120: 384: 16.20		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		654982 VAV_MOUSE (1-746): 9.79e-118: 377: 16.84		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Hs
		855781 VAV2_HUMAN (1-746): 1.37e-111: 361: 15.14		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		1141129 VAV2_MOUSE (1-746): 8.26e-109: 353: 15.28		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Hs
		924777 Q96D37_HUMAN (55-746): 1.96e-101: 332: 14.62		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		1078828 ITSN1_HUMAN (18-575): 4.42e-86: 300: 15.88		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		1078876 PREX1_HUMAN (218-552): 8.7e-83: 291: 23.40		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		1078919 ITSN2_HUMAN (17-575): 4.43e-83: 291: 16.67		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		957987 FGD1_HUMAN (239-698): 2.56e-80: 279: 18.33		SH3R1_HUMAN (271-339): 2.43e-11: 66.8: 20.83