Interactor 1: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 24119142
Identification Methods x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains C2-set_2~C2-set_2, C2-set_2~ig, C2-set_2~Ig_3, ig~ig, Ig_3~ig, Ig_3~Ig_3
Common GO terms GO:0001540 - amyloid-beta binding
GO:0001650 - fibrillar center
GO:0001666 - response to hypoxia
GO:0001774 - microglial cell activation
GO:0001914 - regulation of T cell mediated cytotoxicity
and 56 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 404
Hs

1 404
+ Hs
+ Ce
+ Hs
+ Hs
+ Dm
+ Dm
+ Hs
+ Mm
+ Hs
+ Dm
+ Hs
+ Dm
+ Rn
+ Hs
+ Dm
+ Rn
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024