Protein: PIAS3
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)

Gene: PIAS3
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9Y6X2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003712 - transcription coregulator activity
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

991472

SUMO1
Small ubiquitin-related modifier 1

4

20

Small-scale

0.888

High

993839

UBC9
SUMO-conjugating enzyme UBC9

2

14

High-throughput

0.791

High

964529

SUMO2
Small ubiquitin-related modifier 2

2

20

Small-scale

0.786

High

1338551

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

9

Small-scale

0.740

High

827979

STAT3
Signal transducer and activator of transcription 3

7

5

Small-scale

0.737

High

1045965

TF65
Transcription factor p65

3

7

Small-scale

0.672

High

939243

SUMO3
Small ubiquitin-related modifier 3

1

20

Small-scale

0.647

High

572303

TRI27
Zinc finger protein RFP

2

7

Small-scale

0.643

High

269128

MITF
Microphthalmia-associated transcription factor

2

6

Small-scale

0.636

High

1106772

SMAD4
Mothers against decapentaplegic homolog 4

2

16

Small-scale

0.631

High

1461596

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

9

Small-scale

0.621

High

1032796

SATB1
DNA-binding protein SATB1

2

4

Small-scale

0.595

High

1368547

CBP
CREB-binding protein

2

8

Small-scale

0.586

High

1406406

GFI1
Zinc finger protein Gfi-1

1

2

Small-scale

0.586

High

714565

PML
Protein PML

2

10

High-throughput

0.584

High

1367728

ESR2
Estrogen receptor beta

2

20

Small-scale

0.584

High

227730

SPOP
Speckle-type POZ protein

2

3

Small-scale

0.584

High

1014682

SMAD3
Mothers against decapentaplegic homolog 3

1

16

Small-scale

0.561

High

1153961

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.561

High

988874

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

Small-scale

0.554

High

944607

GEMI4
Gem-associated protein 4

2

0

Small-scale

0.551

High

1156000

ZFHX3
Zinc finger homeobox protein 3

1

0

Small-scale

0.549

High

190097

FOXP2
Forkhead box protein P2

1

2

High-throughput

0.541

High

540978

ERG
Transcriptional regulator ERG

1

14

High-throughput

0.541

High

874022

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

1085496

SRBP2
Sterol regulatory element-binding protein 2

1

13

High-throughput

0.541

High

1121661

MORC3
MORC family CW-type zinc finger protein 3

1

1

High-throughput

0.541

High

1460487

MBD1
Methyl-CpG-binding domain protein 1

1

2

Small-scale

0.529

High

915497

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.529

High

965960

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

Small-scale

0.515

High

603397

KPCA
Protein kinase C alpha type

1

4

High-throughput

0.515

High

1139889

SETB1
Histone-lysine N-methyltransferase SETDB1

1

5

High-throughput

0.515

High

280887

PR40A
Pre-mRNA-processing factor 40 homolog A

1

5

High-throughput

0.508

High

555543

SKIL
Ski-like protein

1

2

High-throughput

0.508

High

647691

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.508

High

968060

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.508

High

211610

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

8

Small-scale

0.501

High

221817

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.501

High

1093456

TRI32
E3 ubiquitin-protein ligase TRIM32

1

12

Small-scale

0.501

High

1307827

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

8

Small-scale

0.501

High

1347013

SNIP1
Smad nuclear-interacting protein 1

1

3

Small-scale

0.501

High

578741

GLNA
Glutamine synthetase

1

2

High-throughput

0.494

High

1371349

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

968846

PRS4
26S proteasome regulatory subunit 4

1

0

High-throughput

0.486

High

520494

ANDR
Androgen receptor

1

20

Small-scale

0.481

High

791886

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

1040655

CREM
cAMP-responsive element modulator

1

3

High-throughput

0.481

High

1207468

HABP4
Intracellular hyaluronan-binding protein 4

1

3

Small-scale

0.481

High

1380897

TRI63
E3 ubiquitin-protein ligase TRIM63

1

16

High-throughput

0.481

High

1419346

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.481

High

1454048

SENP1
Sentrin-specific protease 1

1

2

Small-scale

0.481

High

219885

SMAD6
Mothers against decapentaplegic homolog 6

1

16

Small-scale

0.479

High

397353

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

403054

ANXA1
Annexin A1

1

1

Small-scale

0.479

High

414940

P53
Cellular tumor antigen p53

1

10

High-throughput

0.479

High

442970

PRGR
Progesterone receptor

1

20

Small-scale

0.479

High

541073

PIM1
Serine/threonine-protein kinase pim-1

1

4

Small-scale

0.479

High

652612

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

16

Small-scale

0.479

High

1005309

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

1067895

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.479

High

1089086

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

1133769

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1145802

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

1

Small-scale

0.479

High

1314507

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1420194

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

14

Small-scale

0.479

High

1437715

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

3

Small-scale

0.479

High

1452650

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

2

Small-scale

0.479

High

967091

1433G
14-3-3 protein gamma

1

3

High-throughput

0.470

High

1347424

LMO3
LIM domain only protein 3

1

1

High-throughput

0.470

High

1399313

MUS81
Structure-specific endonuclease subunit MUS81

1

0

Small-scale

0.458

High

1430833

BC11A
BCL11 transcription factor A

1

0

Small-scale

0.458

High

1449664

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.458

High

138543

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.457

High

387488

APOE
Apolipoprotein E

1

2

High-throughput

0.457

High

1057077

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

1250484

MCAF1
Activating transcription factor 7-interacting protein 1

1

3

High-throughput

0.457

High

1150421

NCOA2
Nuclear receptor coactivator 2

1

7

Small-scale

0.445

High

731752

STIP1
Stress-induced-phosphoprotein 1

1

5

Small-scale

0.439

High

771948

CBS
Cystathionine beta-synthase

1

2

Small-scale

0.439

High

1335129

SERB1
SERPINE1 mRNA-binding protein 1

1

3

Small-scale

0.439

High

1460927

ZPI
Protein Z-dependent protease inhibitor

1

1

High-throughput

0.439

High

834244

CSK
Tyrosine-protein kinase CSK

1

2

Small-scale

0.437

High

1126797

BECN1
Beclin-1

1

1

Small-scale

0.437

High

253125

PLIN3
Perilipin-3

2

0

High-throughput

0.316

High

1389339

REX1B
Required for excision 1-B domain-containing protein

1

0

High-throughput

0.265

Low

1490950

CHSP1
Calcium-regulated heat-stable protein 1

1

0

High-throughput

0.265

Low

1387356

OTUB2
Ubiquitin thioesterase OTUB2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025