Protein: NCOA3
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)

Gene: NCOA3
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q9Y6Q9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000993 - RNA polymerase II complex binding
GO:0003713 - transcription coactivator activity
GO:0004402 - histone acetyltransferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

397349

ESR1
Estrogen receptor

29

20

Small-scale

0.992

High

1368546

CBP
CREB-binding protein

12

20

Small-scale

0.977

High

1067894

EP300
Histone acetyltransferase p300

10

20

Small-scale

0.976

High

520654

RARA
Retinoic acid receptor alpha

9

20

Small-scale

0.968

High

1367723

ESR2
Estrogen receptor beta

8

20

Small-scale

0.964

High

520493

ANDR
Androgen receptor

8

20

Small-scale

0.960

High

789611

PPARG
Peroxisome proliferator-activated receptor gamma

8

20

Small-scale

0.950

High

404582

GCR
Glucocorticoid receptor

7

20

Small-scale

0.946

High

543556

VDR
Vitamin D3 receptor

5

20

Small-scale

0.914

High

625858

RXRA
Retinoic acid receptor RXR-alpha

4

20

Small-scale

0.888

High

543603

ERR1
Steroid hormone receptor ERR1

4

20

Small-scale

0.882

High

533370

THB
Thyroid hormone receptor beta

3

20

Small-scale

0.861

High

442969

PRGR
Progesterone receptor

3

20

Small-scale

0.834

High

1041812

PPARD
Peroxisome proliferator-activated receptor delta

2

20

Small-scale

0.778

High

1162098

H31T
Histone H3.1t

2

7

Small-scale

0.778

High

373657

MYC
Myc proto-oncogene protein

2

9

Small-scale

0.754

High

1150420

NCOA2
Nuclear receptor coactivator 2

2

19

Small-scale

0.754

High

1153801

NCOA1
Nuclear receptor coactivator 1

2

19

Small-scale

0.743

High

1293443

CARM1
Histone-arginine methyltransferase CARM1

6

8

Small-scale

0.738

High

227729

SPOP
Speckle-type POZ protein

6

2

Small-scale

0.738

High

177974

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

4

6

Small-scale

0.704

High

1438509

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

20

High-throughput

0.698

High

343289

ERR2
Steroid hormone receptor ERR2

1

20

Small-scale

0.647

High

652611

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

Small-scale

0.647

High

1060644

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

Small-scale

0.647

High

1134819

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

Small-scale

0.647

High

1407035

NPAS2
Neuronal PAS domain-containing protein 2

1

19

Small-scale

0.647

High

168007

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

6

Small-scale

0.646

High

960624

PSME3
Proteasome activator complex subunit 3

2

1

Small-scale

0.641

High

1491850

NEMO
NF-kappa-B essential modulator

2

18

Small-scale

0.634

High

1029185

E2F1
Transcription factor E2F1

2

3

Small-scale

0.629

High

1158216

MK14
Mitogen-activated protein kinase 14

2

6

Small-scale

0.625

High

137552

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.621

High

282958

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

20

Small-scale

0.621

High

522840

COT1
COUP transcription factor 1

1

20

Small-scale

0.621

High

565543

RARG
Retinoic acid receptor gamma

1

20

High-throughput

0.621

High

933969

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.621

High

1095520

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.621

High

1149288

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

20

Small-scale

0.621

High

533239

RARB
Retinoic acid receptor beta

1

20

Small-scale

0.618

High

533314

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.618

High

834106

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.618

High

838262

STAT6
Signal transducer and activator of transcription 6

1

8

Small-scale

0.618

High

902797

RORG
Nuclear receptor ROR-gamma

1

20

Small-scale

0.618

High

799622

BRCA1
Breast cancer type 1 susceptibility protein

2

12

Small-scale

0.613

High

703758

MK01
Mitogen-activated protein kinase 1

2

4

Small-scale

0.602

High

980637

H4
Histone H4

2

7

Small-scale

0.602

High

851829

NKX21
Homeobox protein Nkx-2.1

2

20

Small-scale

0.594

High

1369237

KAT2B
Histone acetyltransferase KAT2B

2

13

Small-scale

0.594

High

885936

KC1E
Casein kinase I isoform epsilon

1

10

Small-scale

0.586

High

700555

PSB9
Proteasome subunit beta type-9

1

5

Small-scale

0.586

High

1109433

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.586

High

143362

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.584

High

474415

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

623612

RO52
E3 ubiquitin-protein ligase TRIM21

2

5

Small-scale

0.584

High

664840

CCND1
G1/S-specific cyclin-D1

2

5

Small-scale

0.584

High

872955

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

1045964

TF65
Transcription factor p65

2

9

Small-scale

0.584

High

1088137

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1153960

SMAD2
Mothers against decapentaplegic homolog 2

2

10

Small-scale

0.584

High

1155960

EZH2
Histone-lysine N-methyltransferase EZH2

2

15

Small-scale

0.584

High

278458

NCOR1
Nuclear receptor corepressor 1

1

17

Small-scale

0.561

High

362430

ABL1
Tyrosine-protein kinase ABL1

1

6

Small-scale

0.561

High

370830

FOS
Protein c-Fos

1

14

Small-scale

0.561

High

635228

HNF1A
Hepatocyte nuclear factor 1-alpha

1

5

Small-scale

0.561

High

896495

ETV1
ETS translocation variant 1

1

20

Small-scale

0.561

High

1051350

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.561

High

1089085

TP53B
TP53-binding protein 1

1

3

Small-scale

0.561

High

1316809

MYCD
Myocardin

1

6

Small-scale

0.561

High

1491796

NCOR2
Nuclear receptor corepressor 2

1

8

Small-scale

0.561

High

559556

XRCC5
X-ray repair cross-complementing protein 5

1

5

High-throughput

0.536

High

571018

MIF
Macrophage migration inhibitory factor

1

2

High-throughput

0.536

High

902255

RAB28
Ras-related protein Rab-28

1

2

High-throughput

0.536

High

1175865

T132A
Transmembrane protein 132A

1

1

High-throughput

0.536

High

1225122

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

7

Small-scale

0.536

High

1451447

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

2

High-throughput

0.536

High

1245820

ATAD2
ATPase family AAA domain-containing protein 2

1

4

Small-scale

0.534

High

1248003

ANR11
Ankyrin repeat domain-containing protein 11

1

7

Small-scale

0.527

High

1403626

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

Small-scale

0.527

High

949475

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

2

Small-scale

0.515

High

951930

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.515

High

1120419

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

6

High-throughput

0.515

High

1386657

OPTN
Optineurin

1

17

High-throughput

0.515

High

390234

ALBU
Albumin

1

0

High-throughput

0.513

High

414939

P53
Cellular tumor antigen p53

1

10

Small-scale

0.501

High

691590

1433T
14-3-3 protein theta

1

6

Small-scale

0.501

High

853761

MK08
Mitogen-activated protein kinase 8

1

6

Small-scale

0.501

High

891930

GSK3B
Glycogen synthase kinase-3 beta

1

4

Small-scale

0.501

High

1381432

MRTFA
Myocardin-related transcription factor A

1

19

Small-scale

0.501

High

1407984

ANM1
Protein arginine N-methyltransferase 1

1

8

Small-scale

0.501

High

1461580

MRTFB
Myocardin-related transcription factor B

1

5

Small-scale

0.501

High

1083478

MN1
Transcriptional activator MN1

1

0

Small-scale

0.480

High

173627

XPO1
Exportin-1

1

10

High-throughput

0.479

High

181586

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

210154

CRX
Cone-rod homeobox protein

1

18

High-throughput

0.479

High

210372

PHF1
PHD finger protein 1

1

2

Small-scale

0.479

High

217013

KLF4
Krueppel-like factor 4

1

14

High-throughput

0.479

High

225153

TLX3
T-cell leukemia homeobox protein 3

1

19

High-throughput

0.479

High

240025

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

260665

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

297722

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

Small-scale

0.479

High

339912

KLF8
Krueppel-like factor 8

1

14

High-throughput

0.479

High

341715

EYA4
Protein phosphatase EYA4

1

7

High-throughput

0.479

High

355627

NSD2
Histone-lysine N-methyltransferase NSD2

1

15

Small-scale

0.479

High

378530

IL1A
Interleukin-1 alpha

1

3

Small-scale

0.479

High

386499

SPTA1
Spectrin alpha chain, erythrocytic 1

1

7

Small-scale

0.479

High

456901

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

538500

EGR2
E3 SUMO-protein ligase EGR2

1

5

High-throughput

0.479

High

540977

ERG
Transcriptional regulator ERG

1

19

High-throughput

0.479

High

552895

TPR
Nucleoprotein TPR

1

9

Small-scale

0.479

High

577518

ETS1
Protein C-ets-1

1

19

Small-scale

0.479

High

578324

ETS2
Protein C-ets-2

1

19

Small-scale

0.479

High

626417

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

Small-scale

0.479

High

651115

RFX1
MHC class II regulatory factor RFX1

1

16

Small-scale

0.479

High

662305

PAX7
Paired box protein Pax-7

1

17

High-throughput

0.479

High

662527

GATA2
Endothelial transcription factor GATA-2

1

5

High-throughput

0.479

High

662680

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

5

High-throughput

0.479

High

681566

PSA3
Proteasome subunit alpha type-3

1

3

Small-scale

0.479

High

685402

PAX6
Paired box protein Pax-6

1

15

High-throughput

0.479

High

725350

TLX1
T-cell leukemia homeobox protein 1

1

17

High-throughput

0.479

High

773108

MYH9
Myosin-9

1

9

Small-scale

0.479

High

775944

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

776277

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

846945

ETV4
ETS translocation variant 4

1

20

High-throughput

0.479

High

873137

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

885459

HXA1
Homeobox protein Hox-A1

1

9

Small-scale

0.479

High

887395

CEBPA
CCAAT/enhancer-binding protein alpha

1

15

High-throughput

0.479

High

937672

FOXG1
Forkhead box protein G1

1

12

Small-scale

0.479

High

938005

FOXA1
Hepatocyte nuclear factor 3-alpha

1

11

High-throughput

0.479

High

938524

PAX9
Paired box protein Pax-9

1

15

High-throughput

0.479

High

942133

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

942483

GSC
Homeobox protein goosecoid

1

15

High-throughput

0.479

High

969105

PRS8
26S proteasome regulatory subunit 8

1

9

Small-scale

0.479

High

996567

ACTS
Actin, alpha skeletal muscle

1

1

Small-scale

0.479

High

1014681

SMAD3
Mothers against decapentaplegic homolog 3

1

10

Small-scale

0.479

High

1033337

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

1040096

PAX2
Paired box protein Pax-2

1

15

High-throughput

0.479

High

1048148

TLE3
Transducin-like enhancer protein 3

1

14

High-throughput

0.479

High

1050587

UBE3A
Ubiquitin-protein ligase E3A

1

8

Small-scale

0.479

High

1053387

CTSL2
CTD small phosphatase-like protein 2

1

1

Small-scale

0.479

High

1056666

PAX8
Paired box protein Pax-8

1

15

High-throughput

0.479

High

1091270

FOXI1
Forkhead box protein I1

1

9

High-throughput

0.479

High

1091760

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

12

Small-scale

0.479

High

1114795

CUL3
Cullin-3

1

10

Small-scale

0.479

High

1118803

KLF5
Krueppel-like factor 5

1

14

High-throughput

0.479

High

1119499

RUNX2
Runt-related transcription factor 2

1

5

Small-scale

0.479

High

1133768

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1138208

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

1145854

IRF4
Interferon regulatory factor 4

1

3

High-throughput

0.479

High

1160908

TBR1
T-box brain protein 1

1

7

High-throughput

0.479

High

1271078

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.479

High

1277059

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1289348

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

4

High-throughput

0.479

High

1339258

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.479

High

1351213

SP7
Transcription factor Sp7

1

14

High-throughput

0.479

High

1364030

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

1380306

FBXW7
F-box/WD repeat-containing protein 7

1

10

Small-scale

0.479

High

1405468

FEV
Protein FEV

1

19

High-throughput

0.479

High

1413245

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1434989

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1445873

GCM1
Chorion-specific transcription factor GCMa

1

1

High-throughput

0.479

High

1460409

KLF15
Krueppel-like factor 15

1

12

High-throughput

0.479

High

1461958

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.479

High

1462292

CHIP
E3 ubiquitin-protein ligase CHIP

1

13

Small-scale

0.479

High

1491860

MORC2
ATPase MORC2

1

1

Small-scale

0.479

High

133391

DCTN6
Dynactin subunit 6

1

0

Small-scale

0.460

High

183990

S22A2
Solute carrier family 22 member 2

1

0

Small-scale

0.460

High

1161810

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

Small-scale

0.460

High

1452091

BABA2
BRISC and BRCA1-A complex member 2

1

0

Small-scale

0.460

High

1137618

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

635018

MAK
Serine/threonine-protein kinase MAK

1

2

Small-scale

0.445

High

1445976

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

14

High-throughput

0.437

High

1322277

IQCK
IQ domain-containing protein K

1

0

Small-scale

0.251

Low

1276390

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025