Protein: PIAS2
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)

Gene: PIAS2
Organism: Homo sapiens
Interactions: 182
UniProt ID: O75928

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

297786

UBC9
SUMO-conjugating enzyme UBC9

11

14

Small-scale

0.978

High

297784

SUMO1
Small ubiquitin-related modifier 1

8

20

Small-scale

0.972

High

297781

SUMO2
Small ubiquitin-related modifier 2

5

20

Small-scale

0.926

High

297778

SUMO3
Small ubiquitin-related modifier 3

3

20

Small-scale

0.841

High

297723

PIAS2
E3 SUMO-protein ligase PIAS2

2

9

Small-scale

0.800

High

297741

XRCC6
X-ray repair cross-complementing protein 6

2

4

High-throughput

0.754

High

297733

P53
Cellular tumor antigen p53

5

10

Small-scale

0.714

High

297828

Q7KZS0
SUMO-conjugating enzyme UBC9

2

14

High-throughput

0.706

High

297802

TRAF2
TNF receptor-associated factor 2

4

6

Small-scale

0.697

High

297762

CBS
Cystathionine beta-synthase

3

2

High-throughput

0.667

High

107790

SUMO5
Small ubiquitin-related modifier 5

1

20

High-throughput

0.665

High

297758

PML
Protein PML

3

10

Small-scale

0.664

High

297742

GFAP
Glial fibrillary acidic protein

4

7

High-throughput

0.647

High

297787

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

High-throughput

0.647

High

297845

TSR2
Pre-rRNA-processing protein TSR2 homolog

3

0

High-throughput

0.646

High

297727

MYC
Myc proto-oncogene protein

3

10

Small-scale

0.646

High

297836

NAV2
Neuron navigator 2

2

7

High-throughput

0.646

High

297728

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

9

High-throughput

0.642

High

297739

ANDR
Androgen receptor

2

20

Small-scale

0.622

High

297837

PIAS4
E3 SUMO-protein ligase PIAS4

1

9

High-throughput

0.621

High

225507

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

0

High-throughput

0.618

High

297740

PCNA
Proliferating cell nuclear antigen

1

3

Small-scale

0.618

High

297724

CCDB1
Cyclin-D1-binding protein 1

2

0

High-throughput

0.613

High

136650

TRAF5
TNF receptor-associated factor 5

2

11

High-throughput

0.606

High

256562

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

2

High-throughput

0.606

High

286833

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

2

1

High-throughput

0.606

High

297745

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

5

High-throughput

0.606

High

297747

CREB1
Cyclic AMP-responsive element-binding protein 1

2

2

High-throughput

0.606

High

297748

DESM
Desmin

2

7

High-throughput

0.606

High

297749

MX1
Interferon-induced GTP-binding protein Mx1

2

3

High-throughput

0.606

High

297752

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

1

High-throughput

0.606

High

297764

SOX5
Transcription factor SOX-5

2

11

High-throughput

0.606

High

297797

MTG8
Protein CBFA2T1

2

1

High-throughput

0.606

High

297803

TRAF3
TNF receptor-associated factor 3

2

9

High-throughput

0.606

High

297806

IKZF1
DNA-binding protein Ikaros

2

2

High-throughput

0.606

High

297810

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

2

3

High-throughput

0.606

High

297824

GRHL2
Grainyhead-like protein 2 homolog

2

1

High-throughput

0.606

High

297825

HMBX1
Homeobox-containing protein 1

2

1

High-throughput

0.606

High

297833

TRI50
E3 ubiquitin-protein ligase TRIM50

2

7

High-throughput

0.606

High

297841

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

1

High-throughput

0.606

High

297852

ZFP42
Zinc finger protein 42 homolog

2

3

High-throughput

0.606

High

297862

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

2

2

High-throughput

0.606

High

297870

HM20A
High mobility group protein 20A

2

5

High-throughput

0.606

High

297872

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

2

6

High-throughput

0.606

High

297876

HMGX4
HMG domain-containing protein 4

2

8

High-throughput

0.606

High

297877

MLX
Max-like protein X

2

9

High-throughput

0.606

High

297751

LMNB1
Lamin-B1

2

10

High-throughput

0.600

High

297732

GCR
Glucocorticoid receptor

2

20

Small-scale

0.595

High

297878

GT2D1
General transcription factor II-I repeat domain-containing protein 1

2

3

Small-scale

0.594

High

297794

FLI1
Friend leukemia integration 1 transcription factor

1

14

Small-scale

0.586

High

297854

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.586

High

297738

PARP1
Poly [ADP-ribose] polymerase 1

2

3

Small-scale

0.584

High

297779

KLF3
Krueppel-like factor 3

2

2

High-throughput

0.584

High

297736

TY3H
Tyrosine 3-monooxygenase

2

0

High-throughput

0.580

High

297774

RFX2
DNA-binding protein RFX2

2

0

High-throughput

0.580

High

297795

ZBT16
Zinc finger and BTB domain-containing protein 16

2

0

High-throughput

0.580

High

297813

SC23A
Protein transport protein Sec23A

2

0

High-throughput

0.580

High

297847

EXOS8
Exosome complex component RRP43

2

0

High-throughput

0.580

High

297851

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.580

High

297861

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

2

0

High-throughput

0.580

High

297873

ZN319
Zinc finger protein 319

2

0

High-throughput

0.580

High

297875

CGBP1
CGG triplet repeat-binding protein 1

2

0

High-throughput

0.580

High

297883

UBQL1
Ubiquilin-1

2

0

High-throughput

0.580

High

297887

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

297773

MK08
Mitogen-activated protein kinase 8

1

1

Small-scale

0.573

High

297888

DNM3A
DNA

1

2

Small-scale

0.573

High

297725

ZBED1
E3 SUMO-protein ligase ZBED1

1

2

High-throughput

0.573

High

297750

MX2
Interferon-induced GTP-binding protein Mx2

1

3

High-throughput

0.573

High

297839

CCHCR
Coiled-coil alpha-helical rod protein 1

1

2

High-throughput

0.573

High

297848

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

4

High-throughput

0.573

High

297815

MK14
Mitogen-activated protein kinase 14

1

1

Small-scale

0.561

High

297830

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

Small-scale

0.561

High

297881

RCOR1
REST corepressor 1

1

1

Small-scale

0.561

High

276652

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

1

High-throughput

0.553

High

297767

TXLNA
Alpha-taxilin

2

2

High-throughput

0.553

High

297769

PERI
Peripherin

2

7

High-throughput

0.553

High

297796

DEUP1
Deuterosome assembly protein 1

2

3

High-throughput

0.553

High

297834

HOME1
Homer protein homolog 1

2

2

High-throughput

0.553

High

297863

KIFC3
Kinesin-like protein KIFC3

2

1

High-throughput

0.553

High

297880

HOOK1
Protein Hook homolog 1

2

2

High-throughput

0.553

High

297743

TRI27
Zinc finger protein RFP

1

7

Small-scale

0.552

High

297855

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.549

High

297765

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.549

High

297744

GLNA
Glutamine synthetase

1

2

High-throughput

0.541

High

297790

GTF2I
General transcription factor II-I

1

3

High-throughput

0.541

High

297800

SRBP2
Sterol regulatory element-binding protein 2

1

13

High-throughput

0.541

High

297805

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.541

High

297734

JUN
Transcription factor Jun

1

6

Small-scale

0.536

High

297763

MSX2
Homeobox protein MSX-2

1

4

Small-scale

0.527

High

297879

MBD1
Methyl-CpG-binding domain protein 1

1

2

Small-scale

0.527

High

297799

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.523

High

297850

ACY3
N-acyl-aromatic-L-amino acid amidohydrolase

1

1

High-throughput

0.523

High

297726

ADA
Adenosine deaminase

1

0

High-throughput

0.518

High

297819

Q59GP6
Polyhomeotic-like protein 1 variant

1

4

High-throughput

0.515

High

297867

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.508

High

221773

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.501

High

269081

MITF
Microphthalmia-associated transcription factor

1

6

Small-scale

0.501

High

297731

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

297735

PRGR
Progesterone receptor

1

20

Small-scale

0.501

High

297771

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

5

Small-scale

0.501

High

297792

SMAD3
Mothers against decapentaplegic homolog 3

1

16

Small-scale

0.501

High

297807

SMAD4
Mothers against decapentaplegic homolog 4

1

16

Small-scale

0.501

High

297809

HIC1
Hypermethylated in cancer 1 protein

1

1

Small-scale

0.501

High

297823

PLAG1
Zinc finger protein PLAG1

1

6

Small-scale

0.501

High

297838

SNIP1
Smad nuclear-interacting protein 1

1

3

Small-scale

0.501

High

297843

ESR2
Estrogen receptor beta

1

20

Small-scale

0.501

High

297882

PLAL1
Zinc finger protein PLAGL1

1

6

Small-scale

0.501

High

297832

TCAM2
TIR domain-containing adapter molecule 2

1

1

High-throughput

0.494

High

211524

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

8

Small-scale

0.481

High

297759

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.481

High

297760

STIP1
Stress-induced-phosphoprotein 1

1

5

Small-scale

0.481

High

297791

PHC1
Polyhomeotic-like protein 1

1

1

High-throughput

0.481

High

297827

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.481

High

297835

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

8

Small-scale

0.481

High

297844

CBP
CREB-binding protein

1

8

Small-scale

0.481

High

297846

TRI63
E3 ubiquitin-protein ligase TRIM63

1

16

High-throughput

0.481

High

297864

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.481

High

297886

ZN451
E3 SUMO-protein ligase ZNF451

1

1

Small-scale

0.481

High

297775

MAPK2
MAP kinase-activated protein kinase 2

1

0

Small-scale

0.480

High

142764

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

240318

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

297737

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

297746

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

297754

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

16

Small-scale

0.479

High

297755

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

4

Small-scale

0.479

High

297756

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

297768

ETV6
Transcription factor ETV6

1

12

High-throughput

0.479

High

297770

ELK3
ETS domain-containing protein Elk-3

1

14

High-throughput

0.479

High

297772

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

Small-scale

0.479

High

297776

CENPA
Histone H3-like centromeric protein A

1

11

High-throughput

0.479

High

297777

PAX9
Paired box protein Pax-9

1

2

High-throughput

0.479

High

297782

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

297783

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

Small-scale

0.479

High

297785

RACK1
Small ribosomal subunit protein RACK1

1

2

Small-scale

0.479

High

297788

H31
Histone H3.1

1

11

High-throughput

0.479

High

297789

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

297793

H33
Histone H3.3

1

11

High-throughput

0.479

High

297801

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

297804

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.479

High

297811

STAT4
Signal transducer and activator of transcription 4

1

5

Small-scale

0.479

High

297812

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

297816

SMN
Survival motor neuron protein

1

1

Small-scale

0.479

High

297826

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

297831

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

1

High-throughput

0.479

High

297840

SP7
Transcription factor Sp7

1

4

High-throughput

0.479

High

297842

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

Small-scale

0.479

High

297853

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

297856

FEV
Protein FEV

1

13

High-throughput

0.479

High

297857

MNT
Max-binding protein MNT

1

8

Small-scale

0.479

High

297858

EPAS1
Endothelial PAS domain-containing protein 1

1

5

Small-scale

0.479

High

297865

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

3

Small-scale

0.479

High

297874

ZMYM2
Zinc finger MYM-type protein 2

1

4

High-throughput

0.479

High

297885

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

297817

Q17R54
Synapsin III

1

3

High-throughput

0.470

High

297780

CLD2
Claudin-2

1

0

Small-scale

0.460

High

297818

BOREA
Borealin

1

0

Small-scale

0.460

High

297757

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

297761

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

297766

COIL
Coilin

1

0

High-throughput

0.458

High

297860

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.458

High

297884

NISCH
Nischarin

1

0

High-throughput

0.458

High

138423

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.457

High

297729

APOE
Apolipoprotein E

1

2

High-throughput

0.457

High

297798

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

297808

DX39B
Spliceosome RNA helicase DDX39B

1

3

Small-scale

0.457

High

297869

CHM1A
Charged multivesicular body protein 1a

1

1

High-throughput

0.457

High

174184

SYN3
Synapsin-3

1

1

High-throughput

0.439

High

104975

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

297868

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

297814

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.426

High

297871

CHMP5
Charged multivesicular body protein 5

1

1

High-throughput

0.417

High

297822

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

238986

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.316

High

297753

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

2

0

High-throughput

0.316

High

297820

LCE1E
Late cornified envelope protein 1E

2

0

High-throughput

0.316

High

297821

LCE2C
Late cornified envelope protein 2C

2

0

High-throughput

0.316

High

297829

CE024
UPF0461 protein C5orf24

2

0

High-throughput

0.316

High

297849

EDC3
Enhancer of mRNA-decapping protein 3

2

0

High-throughput

0.316

High

297859

F118B
Protein FAM118B

2

0

High-throughput

0.316

High

297866

SPC1L
Speriolin-like protein

2

0

High-throughput

0.316

High

297730

C1QA
Complement C1q subcomponent subunit A

1

0

High-throughput

0.282

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025