HitPredict

Interactor 1: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005154 - epidermal growth factor receptor binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1308 Hs			1 261
+	Hs
		412202 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		FYN_HUMAN (6-259): 1.62e-81: 255: 31.68
+	Hs
		442833 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		HCK_HUMAN (7-259): 4.34e-81: 254: 30.39
+	Hs
		433770 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		454834 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		FGR_HUMAN (6-259): 4.1e-79: 249: 30.92
+	Hs
		433359 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		YES_HUMAN (33-259): 1.87e-78: 248: 32.34
+	Hs
		411729 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Hs
		522997 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SRC_HUMAN (13-259): 9.05e-77: 243: 31.37
+	Hs
		846473 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		BLK_HUMAN (2-259): 4.45e-77: 243: 30.88
+	Hs
		996562 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		ITK_HUMAN (8-260): 7.03e-64: 211: 22.56
+	Hs
		788994 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		TEC_HUMAN (7-260): 1.36e-62: 208: 21.81
+	Hs
		789023 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		TXK_HUMAN (1-260): 3.18e-63: 208: 24.72
+	Hs
		337480 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		789067 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		ABL2_HUMAN (11-260): 3.92e-58: 201: 22.09
+	Hs
		1028470 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SLAP1_HUMAN (13-259): 4.83e-60: 193: 38.49
+	Hs
		1046403 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		PTK6_HUMAN (26-251): 9.18e-58: 192: 22.88
+	Hs
		275197 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		924589 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Rn
		1225226 Q8K3F9_RAT (6-1272): 0: 1096: 44.95		SRC_RAT (13-259): 5.35e-77: 244: 31.37
+	Hs
		337346 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		275172 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14