HitPredict

Interactor 1: G5EG62 (G5EG62)
UNC-45
Gene: unc-45

Interactor 2: HSP1 (P09446)
Heat shock protein hsp-1 (Heat shock 70 kDa protein A)
Gene: hsp-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.579

Property	Details
Experiments	23332754
Identification Methods	pull down, x-ray crystallography, isothermal titration calorimetry, molecular sieving
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0044183 - protein folding chaperone
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 961 Ce			1 640
+	Hs
		871653 UN45B_HUMAN (7-943): 0: 822: 30.55		HSP72_HUMAN (2-640): 0: 925: 81.12
+	Hs
		503738 PPP5_HUMAN (5-251): 2.75e-39: 155: 19.12		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		564043 PPP5_HUMAN (5-251): 2.75e-39: 155: 19.12		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Mm
		926131 PPP5_MOUSE (5-199): 1.68e-39: 155: 19.80		HSP7C_MOUSE (1-614): 0: 942: 86.32
+	Hs
		684439 STIP1_HUMAN (5-357): 1e-33: 139: 12.57		HS71L_HUMAN (2-640): 0: 953: 80.60
+	Hs
		504630 TTC1_HUMAN (3-159): 2.06e-38: 147: 29.11		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	At
		612321 OE64C_ARATH (2-126): 9.46e-38: 152: 38.40		HS701_ARATH (2-640): 0: 936: 75.27
+	Hs
		323397 TTC4_HUMAN (6-181): 7.45e-37: 145: 27.53		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	At
		99225 OE64M_ARATH (4-128): 1.96e-36: 148: 36.80		HS701_ARATH (2-640): 0: 936: 75.27
+	Hs
		503534 STIP1_HUMAN (5-357): 1e-33: 139: 12.57		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		503968 PPID_HUMAN (9-133): 5.12e-35: 139: 30.22		HSP7C_HUMAN (1-614): 0: 942: 86.32
+	Hs
		564017 STIP1_HUMAN (5-357): 1e-33: 139: 12.57		HSP76_HUMAN (2-640): 0: 942: 77.22
+	Ce
		183700 STIP1_CAEEL (4-187): 3.17e-31: 127: 16.85		HSP1_CAEEL (1-640): 0: 949: 100.00
+	Dm
		505082 Q9V3E9_DROME (6-164): 1.4e-36: 147: 25.93		HSP7D_DROME (1-613): 0: 927: 84.18
+	Hs
		483776 STIP1_HUMAN (5-357): 1e-33: 139: 12.57		HS71B_HUMAN (1-640): 0: 933: 81.46
+	Hs
		871750 TTC1_HUMAN (3-159): 2.06e-38: 147: 29.11		HSP72_HUMAN (2-640): 0: 925: 81.12
+	Dm
		505089 Q9VEV3_DROME (1-159): 7.34e-37: 141: 28.75		HSP7D_DROME (1-613): 0: 927: 84.18
+	Hs
		684557 STIP1_HUMAN (5-357): 1e-33: 139: 12.57		HSP72_HUMAN (2-640): 0: 925: 81.12
+	At
		1338008 HSOP1_ARATH (4-194): 4.81e-29: 125: 20.42		HS704_ARATH (2-640): 0: 937: 76.01
+	Dm
		505103 Q9VPN5_DROME (5-303): 3.84e-28: 121: 15.74		HSP7D_DROME (1-613): 0: 927: 84.18