Protein: ZC3H3
Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor)

Gene: ZC3H3
Organism: Homo sapiens
Interactions: 228
UniProt ID: Q8IXZ2

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0008270 - zinc ion binding
GO:0031124 - mRNA 3'-end processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1313146

PABP3
Polyadenylate-binding protein 3

3

2

High-throughput

0.861

High

1313095

ZC3H8
Zinc finger CCCH domain-containing protein 8

2

2

High-throughput

0.789

High

841398

RBM34
RNA-binding protein 34

3

9

High-throughput

0.770

High

1313165

RBM28
RNA-binding protein 28

3

4

High-throughput

0.770

High

1313200

RBM19
Probable RNA-binding protein 19

3

4

High-throughput

0.770

High

1313166

PK1IP
p21-activated protein kinase-interacting protein 1

2

1

High-throughput

0.705

High

462507

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

6

High-throughput

0.691

High

1061048

SRSF1
Serine/arginine-rich splicing factor 1

1

11

High-throughput

0.691

High

1247267

WDR74
WD repeat-containing protein 74

1

1

High-throughput

0.691

High

1313100

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

7

High-throughput

0.691

High

1313188

SET1B
Histone-lysine N-methyltransferase SETD1B

1

4

High-throughput

0.691

High

1313194

RBMX2
RNA-binding motif protein, X-linked 2

1

7

High-throughput

0.691

High

257903

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

3

1

High-throughput

0.667

High

274189

ANR17
Ankyrin repeat domain-containing protein 17

3

3

High-throughput

0.667

High

596215

H12
Histone H1.2

3

6

High-throughput

0.667

High

985236

RL10A
Large ribosomal subunit protein uL1

3

3

High-throughput

0.667

High

1037256

H11
Histone H1.1

3

6

High-throughput

0.667

High

1117595

NOG2
Nucleolar GTP-binding protein 2

3

2

High-throughput

0.667

High

1148120

PUM3
Pumilio homolog 3

3

1

High-throughput

0.667

High

1226022

LAR1B
La-related protein 1B

3

5

High-throughput

0.667

High

1307269

H2A2B
Histone H2A type 2-B

3

4

High-throughput

0.667

High

1313094

ZCHC9
Zinc finger CCHC domain-containing protein 9

3

6

High-throughput

0.667

High

1313108

RENT1
Regulator of nonsense transcripts 1

3

2

High-throughput

0.667

High

1313142

GTPB4
GTP-binding protein 4

3

2

High-throughput

0.667

High

1313153

MOV10
Helicase MOV-10

3

2

High-throughput

0.667

High

1313158

SSF1
Suppressor of SWI4 1 homolog

3

1

High-throughput

0.667

High

422534

A4
Amyloid-beta precursor protein

3

0

High-throughput

0.642

High

882339

RM19
Large ribosomal subunit protein bL19m

3

0

High-throughput

0.638

High

1313123

RAB3I
Rab-3A-interacting protein

3

0

High-throughput

0.638

High

1313152

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

3

0

High-throughput

0.638

High

1313155

NGRN
Neugrin

3

0

High-throughput

0.638

High

1313176

ZNF70
Zinc finger protein 70

3

0

High-throughput

0.638

High

1313167

TRM1
tRNA

1

0

High-throughput

0.631

High

1313147

IKZF5
Zinc finger protein Pegasus

2

2

High-throughput

0.628

High

1313109

RL36L
Ribosomal protein eL42-like

3

0

High-throughput

0.628

High

1099152

SRSF5
Serine/arginine-rich splicing factor 5

1

10

High-throughput

0.618

High

1313104

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

1

High-throughput

0.618

High

1313140

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

9

High-throughput

0.618

High

1102014

PABP4
Polyadenylate-binding protein 4

1

2

High-throughput

0.618

High

1194206

LARP7
La-related protein 7

1

10

High-throughput

0.618

High

355555

NSD2
Histone-lysine N-methyltransferase NSD2

2

3

High-throughput

0.611

High

1313150

DDX31
ATP-dependent DNA helicase DDX31

2

4

High-throughput

0.611

High

230054

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

3

3

High-throughput

0.609

High

350920

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

3

2

High-throughput

0.609

High

787564

TNR3
Tumor necrosis factor receptor superfamily member 3

3

2

High-throughput

0.609

High

1011839

RT05
Small ribosomal subunit protein uS5m

3

1

High-throughput

0.609

High

1012893

RT09
Small ribosomal subunit protein uS9m

3

1

High-throughput

0.609

High

1245653

LARP1
La-related protein 1

3

5

High-throughput

0.609

High

1311332

ANKH1
Ankyrin repeat and KH domain-containing protein 1

3

3

High-throughput

0.609

High

1313103

BRX1
Ribosome biogenesis protein BRX1 homolog

3

6

High-throughput

0.609

High

1313111

MTEF3
Transcription termination factor 3, mitochondrial

3

1

High-throughput

0.609

High

1313118

SAHH3
Adenosylhomocysteinase 3

3

3

High-throughput

0.609

High

1313137

RM13
Large ribosomal subunit protein uL13m

3

2

High-throughput

0.609

High

1313149

RPF2
Ribosome production factor 2 homolog

3

1

High-throughput

0.609

High

1313151

RPF1
Ribosome production factor 1

3

2

High-throughput

0.609

High

1313159

DDX21
Nucleolar RNA helicase 2

3

4

High-throughput

0.609

High

1313187

RL26L
Ribosomal protein uL24-like

3

3

High-throughput

0.599

High

290622

SURF6
Surfeit locus protein 6

2

0

High-throughput

0.585

High

960791

RL15
Large ribosomal subunit protein eL15

2

0

High-throughput

0.585

High

1233915

Q6ICH2
single-stranded DNA cytosine deaminase

2

5

High-throughput

0.584

High

1241004

L2GL2
LLGL scribble cell polarity complex component 2

1

0

High-throughput

0.578

High

288976

ERAL1
GTPase Era, mitochondrial

2

1

High-throughput

0.558

High

301115

RL1D1
Ribosomal L1 domain-containing protein 1

2

3

High-throughput

0.558

High

338149

NSA2
Ribosome biogenesis protein NSA2 homolog

2

1

High-throughput

0.558

High

1012213

RT11
Small ribosomal subunit protein uS11m

2

1

High-throughput

0.558

High

1139956

RRS1
Ribosome biogenesis regulatory protein homolog

2

2

High-throughput

0.558

High

1313097

KRI1
Protein KRI1 homolog

2

1

High-throughput

0.558

High

1313141

RT26
Small ribosomal subunit protein mS26

2

1

High-throughput

0.558

High

1313144

DDX24
ATP-dependent RNA helicase DDX24

2

4

High-throughput

0.558

High

1313156

NOP10
H/ACA ribonucleoprotein complex subunit 3

2

1

High-throughput

0.558

High

1313173

NOP53
Ribosome biogenesis protein NOP53

2

2

High-throughput

0.558

High

1313195

RT02
Small ribosomal subunit protein uS2m

2

2

High-throughput

0.558

High

1090256

ELAV2
ELAV-like protein 2

1

4

High-throughput

0.553

High

1313184

PNMA2
Paraneoplastic antigen Ma2

2

1

High-throughput

0.549

High

244734

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.536

High

502421

H2A1
Histone H2A type 1

1

4

High-throughput

0.536

High

600182

ZNF22
Zinc finger protein 22

1

2

High-throughput

0.536

High

624090

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

3

High-throughput

0.536

High

686259

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.536

High

770019

RFC1
Replication factor C subunit 1

1

2

High-throughput

0.536

High

785284

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

975796

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.536

High

978602

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

987100

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.536

High

994646

YBOX1
Y-box-binding protein 1

1

6

High-throughput

0.536

High

1047624

NOTC2
Neurogenic locus notch homolog protein 2

1

4

High-throughput

0.536

High

1098254

DDX10
Probable ATP-dependent RNA helicase DDX10

1

5

High-throughput

0.536

High

1130331

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.536

High

1130777

RRP5
Protein RRP5 homolog

1

1

High-throughput

0.536

High

1252621

ZN574
Zinc finger protein 574

1

1

High-throughput

0.536

High

1271447

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.536

High

1275554

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

3

High-throughput

0.536

High

1308045

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

5

High-throughput

0.536

High

1313102

DDX54
ATP-dependent RNA helicase DDX54

1

4

High-throughput

0.536

High

1313129

BUD13
BUD13 homolog

1

1

High-throughput

0.536

High

1313145

TSYL1
Testis-specific Y-encoded-like protein 1

1

1

High-throughput

0.536

High

1313160

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

5

High-throughput

0.536

High

1313169

AATF
Protein AATF

1

1

High-throughput

0.536

High

1313183

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1313185

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

183025

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.513

High

215836

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

0

High-throughput

0.513

High

353820

PTTG1
Securin

1

0

High-throughput

0.513

High

886531

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

941490

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.513

High

979048

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

982484

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.513

High

982727

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.513

High

1032835

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

1146512

TTF1
Transcription termination factor 1

1

0

High-throughput

0.513

High

1193341

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.513

High

1245166

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

0

High-throughput

0.513

High

1245459

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.513

High

1313115

THOC1
THO complex subunit 1

1

0

High-throughput

0.513

High

1313116

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.513

High

1313120

ZN512
Zinc finger protein 512

1

0

High-throughput

0.513

High

1313122

F111A
Serine protease FAM111A

1

0

High-throughput

0.513

High

1313171

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

1313179

PARP2
Poly [ADP-ribose] polymerase 2

1

0

High-throughput

0.513

High

346046

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.489

High

477821

RM03
Large ribosomal subunit protein uL3m

1

2

High-throughput

0.489

High

630315

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.489

High

856307

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.489

High

1012549

RT34
Small ribosomal subunit protein mS34

1

1

High-throughput

0.489

High

1012723

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.489

High

1112080

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.489

High

1231628

RL7L
Ribosomal protein uL30-like

1

1

High-throughput

0.489

High

1313105

RT27
Small ribosomal subunit protein mS27

1

1

High-throughput

0.489

High

1313117

DDX27
Probable ATP-dependent RNA helicase DDX27

1

5

High-throughput

0.489

High

1313126

DDX50
ATP-dependent RNA helicase DDX50

1

5

High-throughput

0.489

High

1313132

UTP23
rRNA-processing protein UTP23 homolog

1

2

High-throughput

0.489

High

1313133

NOC4L
Nucleolar complex protein 4 homolog

1

1

High-throughput

0.489

High

1313135

MAK16
Protein MAK16 homolog

1

1

High-throughput

0.489

High

1313148

YTDC2
3'-5' RNA helicase YTHDC2

1

2

High-throughput

0.489

High

1313162

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

3

High-throughput

0.489

High

1313163

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.489

High

1313168

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.489

High

1313186

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

2

High-throughput

0.489

High

1313199

RT18C
Small ribosomal subunit protein bS18m

1

3

High-throughput

0.489

High

1313201

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.489

High

341616

EYA4
Protein phosphatase EYA4

1

3

High-throughput

0.479

High

674237

BRD2
Bromodomain-containing protein 2

1

5

High-throughput

0.479

High

810204

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

824225

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.479

High

855128

NOP2
28S rRNA

1

1

High-throughput

0.479

High

1025721

PURA
Transcriptional activator protein Pur-alpha

1

2

High-throughput

0.479

High

1313098

PAPD5
Terminal nucleotidyltransferase 4B

1

5

High-throughput

0.479

High

1313107

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1313143

REXO4
RNA exonuclease 4

1

1

High-throughput

0.479

High

1313178

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1313181

XPO7
Exportin-7

1

3

High-throughput

0.479

High

959853

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

1313134

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

73423

B2CML4
single-stranded DNA cytosine deaminase

1

5

High-throughput

0.445

High

1313110

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

5

High-throughput

0.445

High

960163

RL26
Large ribosomal subunit protein uL24

1

3

High-throughput

0.437

High

1313175

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

1313182

HERC5
E3 ISG15--protein ligase HERC5

1

2

High-throughput

0.437

High

96880

E9PDP5
Ankyrin repeat and KH domain containing 1

1

3

High-throughput

0.407

High

158578

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

3

0

High-throughput

0.347

High

271071

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

3

0

High-throughput

0.347

High

902523

RT29
Small ribosomal subunit protein mS29

3

0

High-throughput

0.347

High

985497

RL32
Large ribosomal subunit protein eL32

3

0

High-throughput

0.347

High

1011484

RT10
Small ribosomal subunit protein uS10m

3

0

High-throughput

0.347

High

1011658

RT35
Small ribosomal subunit protein mS35

3

0

High-throughput

0.347

High

1313112

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

3

0

High-throughput

0.347

High

1313114

PTCD3
Small ribosomal subunit protein mS39

3

0

High-throughput

0.347

High

1313170

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

3

0

High-throughput

0.347

High

1313190

RT33
Small ribosomal subunit protein mS33

3

0

High-throughput

0.347

High

1313193

SYYM
Tyrosine--tRNA ligase, mitochondrial

3

0

High-throughput

0.347

High

239124

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

1256695

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

1313096

TM102
Transmembrane protein 102

2

0

High-throughput

0.328

High

1313177

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

0

High-throughput

0.328

High

256328

RT14
Small ribosomal subunit protein uS14m

2

0

High-throughput

0.318

High

1011311

RT25
Small ribosomal subunit protein mS25

2

0

High-throughput

0.318

High

1012428

RT21
Small ribosomal subunit protein bS21m

2

0

High-throughput

0.318

High

1313093

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

0

High-throughput

0.318

High

1313101

RM30
Large ribosomal subunit protein uL30m

2

0

High-throughput

0.318

High

1313106

RT31
Small ribosomal subunit protein mS31

2

0

High-throughput

0.318

High

1313113

RT24
Small ribosomal subunit protein uS3m

2

0

High-throughput

0.318

High

1313125

POP1
Ribonucleases P/MRP protein subunit POP1

2

0

High-throughput

0.318

High

1313127

RM34
Large ribosomal subunit protein bL34m

2

0

High-throughput

0.318

High

1313136

RM32
Large ribosomal subunit protein bL32m

2

0

High-throughput

0.318

High

1313138

RM09
Large ribosomal subunit protein bL9m

2

0

High-throughput

0.318

High

1313139

RM01
Large ribosomal subunit protein uL1m

2

0

High-throughput

0.318

High

1313161

RM17
Large ribosomal subunit protein bL17m

2

0

High-throughput

0.318

High

1313189

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

2

0

High-throughput

0.318

High

1313197

NOP16
Nucleolar protein 16

2

0

High-throughput

0.318

High

391340

FRIL
Ferritin light chain

2

0

High-throughput

0.313

High

140605

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

1

0

High-throughput

0.279

Low

164158

KIF3C
Kinesin-like protein KIF3C

1

0

High-throughput

0.279

Low

164697

TNF11
Tumor necrosis factor ligand superfamily member 11

1

0

High-throughput

0.279

Low

208304

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.279

Low

428443

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.279

Low

1004362

NOP14
Nucleolar protein 14

1

0

High-throughput

0.279

Low

1012340

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.279

Low

1037549

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.279

Low

1063807

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.279

Low

1065849

MZT1
Mitotic-spindle organizing protein 1

1

0

High-throughput

0.279

Low

1130937

BMS1
Ribosome biogenesis protein BMS1 homolog

1

0

High-throughput

0.279

Low

1287509

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.279

Low

1313099

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.279

Low

1313119

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1313121

TMM74
Transmembrane protein 74

1

0

High-throughput

0.279

Low

1313124

MTMR9
Myotubularin-related protein 9

1

0

High-throughput

0.279

Low

1313128

RT63
Large ribosomal subunit protein mL63

1

0

High-throughput

0.279

Low

1313130

CHOLN
Protein cholesin

1

0

High-throughput

0.279

Low

1313154

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.279

Low

1313157

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.279

Low

1313164

SPS2L
SPATS2-like protein

1

0

High-throughput

0.279

Low

1313172

RM35
Large ribosomal subunit protein bL35m

1

0

High-throughput

0.279

Low

1313174

RM15
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.279

Low

1313180

RLP24
Probable ribosome biogenesis protein RLP24

1

0

High-throughput

0.279

Low

1313191

NISCH
Nischarin

1

0

High-throughput

0.279

Low

1313192

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.279

Low

1313196

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.279

Low

1313198

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.279

Low

75994

B4DEF8
Large ribosomal subunit protein mL45

1

0

High-throughput

0.249

Low

334438

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

584658

HIS3
Histatin-3

1

0

Small-scale

0.249

Low

657630

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

1011121

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.249

Low

1240835

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.249

Low

1275794

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.249

Low

1313131

LLPH
Protein LLP homolog

1

0

High-throughput

0.249

Low

58863

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

1136815

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025