Protein: MKRN2
E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)

Gene: MKRN2
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q9H000

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

473065

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

17

High-throughput

0.861

High

1409834

RBM4B
RNA-binding protein 4B

3

20

High-throughput

0.861

High

992953

RACK1
Small ribosomal subunit protein RACK1

3

3

High-throughput

0.845

High

135342

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

2

17

Small-scale

0.834

High

1090295

ELAV2
ELAV-like protein 2

2

19

High-throughput

0.811

High

1245413

ZC3HE
Zinc finger CCCH domain-containing protein 14

2

1

High-throughput

0.789

High

550458

PABP1
Polyadenylate-binding protein 1

2

12

High-throughput

0.754

High

1102088

PABP4
Polyadenylate-binding protein 4

2

12

High-throughput

0.754

High

1429243

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

8

High-throughput

0.754

High

906779

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

14

Small-scale

0.701

High

1429220

PAIP1
Polyadenylate-binding protein-interacting protein 1

4

3

High-throughput

0.694

High

64810

EPAB2
Embryonic polyadenylate-binding protein 2

1

18

High-throughput

0.691

High

74595

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

13

High-throughput

0.691

High

256679

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

13

High-throughput

0.691

High

462625

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

17

High-throughput

0.691

High

1009316

PRR3
Proline-rich protein 3

1

3

High-throughput

0.691

High

1016605

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.691

High

1148786

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

20

High-throughput

0.691

High

1290143

THOC4
THO complex subunit 4

1

10

High-throughput

0.691

High

1387886

PABP5
Polyadenylate-binding protein 5

1

12

High-throughput

0.691

High

1429222

PAR12
Protein mono-ADP-ribosyltransferase PARP12

4

3

High-throughput

0.691

High

1429258

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

14

High-throughput

0.675

High

1096217

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.665

High

1326550

CARME
Carnosine N-methyltransferase

4

0

High-throughput

0.661

High

192640

NUP42
Nucleoporin NUP42

3

1

High-throughput

0.656

High

1290712

ZCH18
Zinc finger CCCH domain-containing protein 18

2

3

High-throughput

0.628

High

48069

RBM47
RNA-binding protein 47

1

18

High-throughput

0.618

High

172207

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

20

High-throughput

0.618

High

214929

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

18

High-throughput

0.618

High

222526

PLRG1
Pleiotropic regulator 1

1

3

High-throughput

0.618

High

250813

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

17

High-throughput

0.618

High

688311

TTP
mRNA decay activator protein ZFP36

1

1

High-throughput

0.618

High

713849

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

20

High-throughput

0.618

High

988206

TRA2B
Transformer-2 protein homolog beta

1

17

High-throughput

0.618

High

1007780

RAE1L
mRNA export factor RAE1

1

3

High-throughput

0.618

High

1093713

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

8

High-throughput

0.618

High

1111863

TRA2A
Transformer-2 protein homolog alpha

1

15

High-throughput

0.618

High

1287831

PABP2
Polyadenylate-binding protein 2

1

17

High-throughput

0.618

High

1310642

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

1

High-throughput

0.618

High

1369835

CELF1
CUGBP Elav-like family member 1

1

19

High-throughput

0.618

High

1370238

DAZL
Deleted in azoospermia-like

1

15

High-throughput

0.618

High

1416115

RBM4
RNA-binding protein 4

1

20

Small-scale

0.618

High

1418573

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

20

High-throughput

0.618

High

1429227

RC3H2
Roquin-2

1

5

High-throughput

0.618

High

1429229

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

4

High-throughput

0.618

High

1429239

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

10

High-throughput

0.618

High

1429250

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

High-throughput

0.618

High

1429264

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

13

High-throughput

0.618

High

1405676

NECD
Necdin

2

3

High-throughput

0.613

High

1365665

LAR4B
La-related protein 4B

2

11

High-throughput

0.611

High

1429257

TR150
Thyroid hormone receptor-associated protein 3

2

6

High-throughput

0.611

High

1239103

HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

3

1

High-throughput

0.609

High

1429242

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.602

High

96100

E9KL35
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.594

High

1429260

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.586

High

272999

ZC11A
Zinc finger CCCH domain-containing protein 11A

2

0

High-throughput

0.585

High

242860

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

1233944

Q6ICH2
single-stranded DNA cytosine deaminase

2

12

High-throughput

0.584

High

1406486

ATX2
Ataxin-2

2

4

High-throughput

0.584

High

414582

P53
Cellular tumor antigen p53

1

1

Small-scale

0.578

High

1256733

NKAP1
Uncharacterized protein NKAPD1

2

2

High-throughput

0.574

High

843964

HD
Huntingtin

2

0

High-throughput

0.571

High

1056959

FMR1
Fragile X messenger ribonucleoprotein 1

2

0

High-throughput

0.559

High

1199374

GLE1
mRNA export factor GLE1

2

0

High-throughput

0.559

High

1429236

AIRIM
AFG2-interacting ribosome maturation factor

1

0

High-throughput

0.549

High

1418792

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

High-throughput

0.541

High

1045747

TF65
Transcription factor p65

1

0

Small-scale

0.537

High

244767

ZC3H1
Zinc finger C3H1 domain-containing protein

1

3

High-throughput

0.536

High

344314

PTBP3
Polypyrimidine tract-binding protein 3

1

14

High-throughput

0.536

High

1155743

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.536

High

1168888

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

4

High-throughput

0.536

High

1250657

BCOR
BCL-6 corepressor

1

6

Small-scale

0.536

High

1429221

SHRPN
Sharpin

1

2

High-throughput

0.536

High

1429240

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.536

High

1429247

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

2

High-throughput

0.536

High

1395580

PDLI2
PDZ and LIM domain protein 2

1

0

Small-scale

0.529

High

647653

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.513

High

1339701

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

889501

CLK1
Dual specificity protein kinase CLK1

1

3

High-throughput

0.501

High

996018

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

15

Small-scale

0.501

High

1364110

TM9S4
Transmembrane 9 superfamily member 4

1

1

High-throughput

0.489

High

957667

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

18

High-throughput

0.481

High

982317

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

14

High-throughput

0.481

High

173332

XPO1
Exportin-1

1

4

High-throughput

0.479

High

273927

CNOT3
CCR4-NOT transcription complex subunit 3

1

1

High-throughput

0.479

High

286277

CSDE1
Cold shock domain-containing protein E1

1

1

High-throughput

0.479

High

320044

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

406624

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

460634

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

487731

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

542643

TOP2A
DNA topoisomerase 2-alpha

1

2

High-throughput

0.479

High

668710

APC
Adenomatous polyposis coli protein

1

4

High-throughput

0.479

High

773010

MYH9
Myosin-9

1

1

High-throughput

0.479

High

773272

MYH10
Myosin-10

1

1

High-throughput

0.479

High

799467

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

834528

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

875779

PRC2A
Protein PRRC2A

1

5

High-throughput

0.479

High

954263

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

1032410

OTUD4
OTU domain-containing protein 4

1

2

High-throughput

0.479

High

1056646

PAX8
Paired box protein Pax-8

1

2

Small-scale

0.479

High

1059955

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

High-throughput

0.479

High

1092235

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

1114249

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1122157

UBP2L
Ubiquitin-associated protein 2-like

1

2

High-throughput

0.479

High

1129499

PUM1
Pumilio homolog 1

1

4

High-throughput

0.479

High

1138949

R3HD1
R3H domain-containing protein 1

1

3

High-throughput

0.479

High

1165502

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

14

High-throughput

0.479

High

1197562

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.479

High

1201696

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

3

High-throughput

0.479

High

1206541

PRC2B
Protein PRRC2B

1

3

High-throughput

0.479

High

1215820

RC3H1
Roquin-1

1

2

High-throughput

0.479

High

1219429

TUT7
Terminal uridylyltransferase 7

1

1

High-throughput

0.479

High

1226043

LAR1B
La-related protein 1B

1

11

High-throughput

0.479

High

1229074

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

1240492

DHX57
Putative ATP-dependent RNA helicase DHX57

1

5

High-throughput

0.479

High

1245733

LARP1
La-related protein 1

1

12

High-throughput

0.479

High

1259152

LARP4
La-related protein 4

1

11

High-throughput

0.479

High

1275664

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

5

High-throughput

0.479

High

1280737

YTHD3
YTH domain-containing family protein 3

1

3

High-throughput

0.479

High

1287123

PATL1
Protein PAT1 homolog 1

1

1

High-throughput

0.479

High

1308626

PKHH2
Pleckstrin homology domain-containing family H member 2

1

1

High-throughput

0.479

High

1325003

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

2

High-throughput

0.479

High

1331962

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

1

High-throughput

0.479

High

1334897

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1336295

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.479

High

1336837

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

4

High-throughput

0.479

High

1340617

TDRD7
Tudor domain-containing protein 7

1

1

High-throughput

0.479

High

1348123

PUM2
Pumilio homolog 2

1

4

High-throughput

0.479

High

1351467

BRX1
Ribosome biogenesis protein BRX1 homolog

1

6

High-throughput

0.479

High

1357551

DCAF4
DDB1- and CUL4-associated factor 4

1

2

High-throughput

0.479

High

1363969

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

1370104

RENT1
Regulator of nonsense transcripts 1

1

7

High-throughput

0.479

High

1393947

FUBP3
Far upstream element-binding protein 3

1

11

High-throughput

0.479

High

1400477

SMG1
Serine/threonine-protein kinase SMG1

1

1

High-throughput

0.479

High

1404378

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.479

High

1409764

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

2

High-throughput

0.479

High

1412091

TRI56
E3 ubiquitin-protein ligase TRIM56

1

4

High-throughput

0.479

High

1418717

YTHD1
YTH domain-containing family protein 1

1

3

High-throughput

0.479

High

1420920

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

14

High-throughput

0.479

High

1429223

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1429226

AGO3
Protein argonaute-3

1

3

High-throughput

0.479

High

1429228

MOV10
Helicase MOV-10

1

7

High-throughput

0.479

High

1429234

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

1

High-throughput

0.479

High

1429235

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

10

High-throughput

0.479

High

1429237

BCLF1
Bcl-2-associated transcription factor 1

1

6

High-throughput

0.479

High

1429238

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

2

High-throughput

0.479

High

1429241

SYLC
Leucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

1429244

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

1429245

AGO2
Protein argonaute-2

1

3

High-throughput

0.479

High

1429246

AGO1
Protein argonaute-1

1

3

High-throughput

0.479

High

1429248

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.479

High

1429249

PRP19
Pre-mRNA-processing factor 19

1

4

High-throughput

0.479

High

1429252

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

3

High-throughput

0.479

High

1429253

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

2

High-throughput

0.479

High

1429255

R3HD2
R3H domain-containing protein 2

1

3

High-throughput

0.479

High

1429259

LC7L2
Putative RNA-binding protein Luc7-like 2

1

3

High-throughput

0.479

High

1429261

PRC2C
Protein PRRC2C

1

2

High-throughput

0.479

High

1429262

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.479

High

64113

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

290144

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

294301

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

352544

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

731601

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

1124048

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1126536

CAPR1
Caprin-1

1

0

High-throughput

0.458

High

1131125

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

High-throughput

0.458

High

1151385

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1187076

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

1252382

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1336212

RN214
RING finger protein 214

1

0

High-throughput

0.458

High

1356828

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

1365354

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

1399000

BROMI
Protein broad-minded

1

0

Small-scale

0.458

High

1400750

UIF
UAP56-interacting factor

1

0

High-throughput

0.458

High

1403241

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.458

High

1429224

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1429225

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.458

High

1429233

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

73450

B2CML4
single-stranded DNA cytosine deaminase

1

12

High-throughput

0.445

High

1383328

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

12

High-throughput

0.445

High

1429256

YBOX2
Y-box-binding protein 2

1

10

High-throughput

0.445

High

340233

PCNT
Pericentrin

1

3

High-throughput

0.437

High

675151

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

High-throughput

0.437

High

1150949

TRIPB
Thyroid receptor-interacting protein 11

1

2

High-throughput

0.437

High

1241584

CEP85
Centrosomal protein of 85 kDa

1

3

High-throughput

0.437

High

1350181

ALMS1
Centrosome-associated protein ALMS1

1

1

High-throughput

0.437

High

1351973

RBCC1
RB1-inducible coiled-coil protein 1

1

2

High-throughput

0.437

High

1429231

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

1

High-throughput

0.437

High

1429251

CP131
Centrosomal protein of 131 kDa

1

3

High-throughput

0.437

High

1429254

ANR26
Ankyrin repeat domain-containing protein 26

1

4

High-throughput

0.437

High

1034525

TAGL
Transgelin

1

0

High-throughput

0.426

High

75534

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

16

High-throughput

0.417

High

131509

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

0

High-throughput

0.316

High

1031951

NC2B
Protein Dr1

1

0

High-throughput

0.268

Low

1429263

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.268

Low

176543

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

873922

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.249

Low

1178009

MOONR
Protein moonraker

1

0

High-throughput

0.249

Low

1333328

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1336170

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.249

Low

1348208

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1397833

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

1429230

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low

1429232

ANLN
Anillin

1

0

High-throughput

0.249

Low

388455

B3AT
Band 3 anion transport protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025