HitPredict

Interactor 1: HIF1 (G5EGD2)
Hypoxia-inducible factor 1 (Hypoxia-induced factor 1)
Gene: hif-1

Interactor 2: CBP1 (P34545)
Protein cbp-1 (EC 2.3.1.48)
Gene: cbp-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	10973497
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 719 Ce			1 2017
+	Mm
		799605 BMAL1_MOUSE (4-530): 6.92e-131: 403: 15.01		CBP_MOUSE (4-1972): 0: 840: 26.67
+	Mm
		799600 BMAL2_MOUSE (13-530): 4.5e-105: 334: 16.61		CBP_MOUSE (4-1972): 0: 840: 26.67
+	Hs
		1085624 HIF1A_HUMAN (2-488): 5.69e-130: 406: 24.71		KAT2B_HUMAN (362-969): 3.3e-44: 176: 9.80
+	Hs
		126157 BMAL1_HUMAN (4-530): 3.58e-129: 398: 15.16		KAT2B_HUMAN (362-969): 3.3e-44: 176: 9.80
+	Hs
		170379 NCOA1_HUMAN (2-575): 3.99e-99: 335: 14.78		TIF1A_HUMAN (400-1011): 1.4e-44: 179: 11.56
+	Hs
		1078531 NCOA1_HUMAN (2-575): 3.99e-99: 335: 14.78		KAT2B_HUMAN (362-969): 3.3e-44: 176: 9.80
+	Mm
		70923 HIF1A_MOUSE (2-506): 3.53e-135: 420: 25.42		EP300_MOUSE (172-698): 9.27e-09: 63.2: 8.04
+	Rn
		193481 HIF1A_RAT (2-488): 1.38e-132: 413: 25.15		CBP_RAT (19-562): 1.14e-09: 66.3: 8.26
+	Hs
		649093 ARNT_HUMAN (2-560): 2.82e-131: 408: 18.03		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		998777 HIF1A_HUMAN (2-488): 5.69e-130: 406: 24.71		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		1085623 HIF1A_HUMAN (2-488): 5.69e-130: 406: 24.71		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Mm
		70944 BMAL1_MOUSE (4-530): 6.92e-131: 403: 15.01		EP300_MOUSE (172-698): 9.27e-09: 63.2: 8.04
+	Hs
		126124 BMAL1_HUMAN (4-530): 3.58e-129: 398: 15.16		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		126156 BMAL1_HUMAN (4-530): 3.58e-129: 398: 15.16		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Hs
		999019 EPAS1_HUMAN (2-466): 7.27e-124: 391: 22.67		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		1270775 EPAS1_HUMAN (2-466): 7.27e-124: 391: 22.67		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Hs
		998754 NCOA1_HUMAN (2-575): 3.99e-99: 335: 14.78		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75
+	Hs
		1078530 NCOA1_HUMAN (2-575): 3.99e-99: 335: 14.78		CBP_HUMAN (142-686): 8.75e-09: 63.2: 9.89
+	Mm
		70918 BMAL2_MOUSE (13-530): 4.5e-105: 334: 16.61		EP300_MOUSE (172-698): 9.27e-09: 63.2: 8.04
+	Hs
		998745 NCOA2_HUMAN (2-576): 2.43e-98: 333: 15.71		EP300_HUMAN (20-436): 5.06e-09: 63.9: 10.75