HitPredict

Interactor 1: NEXN (Q0ZGT2)
Nexilin (F-actin-binding protein) (Nelin)
Gene: NEXN

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~I-set
Common GO terms	GO:0015629 - actin cytoskeleton GO:0030424 - axon
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 675 Hs			1 376
+	Hs
		952781 NEXN_HUMAN (1-675): 9e-105: 335: 100.00		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		995555 NEXN_HUMAN (1-675): 9e-105: 335: 100.00		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		977685 NEXN_HUMAN (1-675): 9e-105: 335: 100.00		ACTA_HUMAN (1-376): 0: 586: 87.80
+	Hs
		541420 FGFR1_HUMAN (349-674): 3.55e-41: 162: 13.51		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		541429 FGFR1_HUMAN (349-674): 3.55e-41: 162: 13.51		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		541430 FGFR1_HUMAN (349-674): 3.55e-41: 162: 13.51		ACTS_HUMAN (2-376): 0: 588: 87.47
+	Hs
		952825 MYPC3_HUMAN (10-653): 1.07e-31: 134: 11.78		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		995595 MYPC3_HUMAN (10-653): 1.07e-31: 134: 11.78		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Dm
		1014441 Q8MYR8_DROME (535-671): 5.55e-20: 96.3: 19.71		ACT6_DROME (1-376): 0: 594: 88.83
+	Hs
		952989 PALLD_HUMAN (573-675): 5.32e-11: 68.3: 23.08		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Dm
		56405 A1ZA72_DROME (357-675): 3.93e-10: 65.7: 13.08		ACT6_DROME (1-376): 0: 594: 88.83
+	Mm
		267094 MYPC3_MOUSE (238-674): 1.25e-11: 70.3: 12.04		ACTC_MOUSE (2-376): 0: 589: 88.27
+	Dm
		387049 Q7KQP6_DROME (246-671): 8.17e-09: 61.4: 12.33		ACT4_DROME (1-376): 0: 589: 89.10