Protein: NEXN
Nexilin (F-actin-binding protein) (Nelin)

Gene: NEXN
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q0ZGT2

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0005912 - adherens junction
GO:0005925 - focal adhesion
GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007411 - axon guidance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

952781

ACTB
Actin, cytoplasmic 1

3

13

High-throughput

0.861

High

977685

ACTA
Actin, aortic smooth muscle

2

13

High-throughput

0.811

High

1082533

ANK3
Ankyrin-3

2

9

High-throughput

0.811

High

1082548

ACTBL
Beta-actin-like protein 2

2

13

High-throughput

0.811

High

1082579

ARP10
Actin-related protein 10

2

13

High-throughput

0.726

High

920432

DAPK1
Death-associated protein kinase 1

1

13

High-throughput

0.691

High

995555

ACTC
Actin, alpha cardiac muscle 1

1

12

High-throughput

0.691

High

1082550

EMB
Embigin

1

19

High-throughput

0.691

High

1005356

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

19

Small-scale

0.647

High

227861

MYO1B
Unconventional myosin-Ib

2

16

High-throughput

0.628

High

442306

GELS
Gelsolin

2

3

High-throughput

0.628

High

1082582

LIMA1
LIM domain and actin-binding protein 1

2

7

High-throughput

0.628

High

1082585

NEB1
Neurabin-1

2

12

High-throughput

0.628

High

1082564

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

6

High-throughput

0.618

High

1082566

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.618

High

1082572

ANLN
Anillin

2

2

High-throughput

0.611

High

371876

MYC
Myc proto-oncogene protein

2

10

High-throughput

0.584

High

900294

FXR2
RNA-binding protein FXR2

2

5

High-throughput

0.553

High

136082

PLK4
Serine/threonine-protein kinase PLK4

1

6

Small-scale

0.553

High

157291

CTRO
Citron Rho-interacting kinase

1

14

High-throughput

0.553

High

415528

HSPB1
Heat shock protein beta-1

1

10

High-throughput

0.541

High

318311

MYO1D
Unconventional myosin-Id

1

16

High-throughput

0.536

High

637477

FLNA
Filamin-A

1

16

High-throughput

0.536

High

772765

MYH9
Myosin-9

1

10

High-throughput

0.536

High

862818

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.536

High

968271

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.536

High

987344

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.536

High

1051999

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1082537

CUL1
Cullin-1

1

12

High-throughput

0.536

High

1082538

SRC8
Src substrate cortactin

1

11

High-throughput

0.536

High

1082543

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

1082544

DREB
Drebrin

1

13

High-throughput

0.536

High

1082553

SYNPO
Synaptopodin

1

5

High-throughput

0.536

High

1082561

MYO19
Unconventional myosin-XIX

1

15

High-throughput

0.536

High

1082563

S39A3
Zinc transporter ZIP3

1

2

High-throughput

0.536

High

1082573

MYO5C
Unconventional myosin-Vc

1

9

High-throughput

0.536

High

701974

TMOD1
Tropomodulin-1

2

1

High-throughput

0.521

High

981802

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

1082584

MUCEN
Endomucin

1

0

High-throughput

0.513

High

1082551

FBX46
F-box only protein 46

1

1

High-throughput

0.489

High

1082574

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.489

High

1082576

FBX34
F-box only protein 34

1

1

High-throughput

0.489

High

1082577

MTMRA
Myotubularin-related protein 10

1

3

High-throughput

0.489

High

1082583

NXT1
NTF2-related export protein 1

1

2

High-throughput

0.489

High

123679

MYO1C
Unconventional myosin-Ic

1

17

High-throughput

0.479

High

403163

APOB
Apolipoprotein B-100

1

1

High-throughput

0.479

High

537052

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

767426

RADI
Radixin

1

11

High-throughput

0.479

High

866656

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.479

High

867078

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

986373

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1082535

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

1082541

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1082552

RHG24
Rho GTPase-activating protein 24

1

9

High-throughput

0.479

High

1082556

MY18A
Unconventional myosin-XVIIIa

1

12

High-throughput

0.479

High

1082560

VMP1
Vacuole membrane protein 1

1

1

High-throughput

0.479

High

1082570

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

1082580

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

1082581

TES
Testin

1

11

High-throughput

0.479

High

1082565

CECR2
Chromatin remodeling regulator CECR2

1

4

High-throughput

0.470

High

481262

HMGB1
High mobility group protein B1

1

5

High-throughput

0.464

High

687229

HMGB2
High mobility group protein B2

1

5

High-throughput

0.464

High

352761

F107A
Actin-associated protein FAM107A

1

0

Small-scale

0.460

High

1082567

TRI15
E3 ubiquitin-protein ligase TRIM15

1

0

Small-scale

0.460

High

786570

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

7

High-throughput

0.445

High

942584

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

16

High-throughput

0.445

High

987590

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.445

High

1033968

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

1082542

CNN3
Calponin-3

1

5

High-throughput

0.445

High

1082586

COR2B
Coronin-2B

1

8

High-throughput

0.445

High

293623

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

323347

TRI37
E3 ubiquitin-protein ligase TRIM37

1

8

High-throughput

0.437

High

551012

PCNA
Proliferating cell nuclear antigen

1

4

High-throughput

0.437

High

1082534

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

16

Small-scale

0.437

High

1082539

CUL7
Cullin-7

1

1

High-throughput

0.437

High

1082540

TNIP1
TNFAIP3-interacting protein 1

1

19

High-throughput

0.437

High

1082547

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

7

High-throughput

0.437

High

1082555

NUDC2
NudC domain-containing protein 2

1

3

High-throughput

0.437

High

1082557

NELL1
Protein kinase C-binding protein NELL1

1

11

Small-scale

0.437

High

1082558

STMN2
Stathmin-2

1

1

High-throughput

0.437

High

1082562

MEP50
Methylosome protein WDR77

1

8

High-throughput

0.437

High

1082571

ECT2
Protein ECT2

1

12

High-throughput

0.437

High

1082587

MB212
Protein mab-21-like 2

1

2

High-throughput

0.437

High

387110

TNNC2
Troponin C, skeletal muscle

1

1

High-throughput

0.407

High

708848

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

10

High-throughput

0.407

High

1082536

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.407

High

1082568

TOLIP
Toll-interacting protein

1

2

High-throughput

0.407

High

1082569

CPVL
Probable serine carboxypeptidase CPVL

2

0

High-throughput

0.328

High

517580

ZSC22
Zinc finger and SCAN domain-containing protein 22

2

0

High-throughput

0.316

High

585023

ZN250
Zinc finger protein 250

2

0

High-throughput

0.316

High

456060

CRGD
Gamma-crystallin D

1

0

High-throughput

0.279

Low

1082545

CC036
Uncharacterized protein C3orf36

1

0

High-throughput

0.279

Low

1082559

OTUB2
Ubiquitin thioesterase OTUB2

1

0

High-throughput

0.279

Low

1082554

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.269

Low

1082549

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

1082546

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

0

High-throughput

0.232

Low

1082575

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low

1082578

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025