HitPredict

Interactor 1: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Interactor 2: PINK1 (Q9BXM7)
Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Gene: PINK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	28438176, 30783609, 21151955, 18003639, 18359116, 25036637
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0050821 - protein stabilization GO:0098779 - positive regulation of mitophagy in response to mitochondrial depolarization
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 378 Hs			1 581
+	Hs
		784018 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		1083052 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT3_HUMAN (110-573): 2.43e-120: 365: 13.88
+	Hs
		681873 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT1_HUMAN (115-573): 2.58e-118: 360: 12.89
+	Hs
		682179 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		AKT2_HUMAN (115-573): 1.5e-117: 358: 12.66
+	Hs
		983850 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KPCZ_HUMAN (54-568): 6.17e-114: 353: 13.97
+	Hs
		568678 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Hs
		850660 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A3_HUMAN (154-555): 2.08e-92: 301: 16.59
+	Hs
		1071643 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A2_HUMAN (197-576): 4.99e-92: 300: 15.42
+	Hs
		1073425 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A1_HUMAN (157-555): 9.95e-91: 296: 15.63
+	Hs
		1083040 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KS6A6_HUMAN (203-555): 8.05e-90: 294: 15.41
+	Hs
		1083050 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KCC2A_HUMAN (221-538): 5.11e-82: 266: 20.62
+	Rn
		506753 CDC37_RAT (1-377): 8.29e-168: 475: 95.24		KCC2A_RAT (221-538): 4.46e-82: 266: 20.62
+	Hs
		1038971 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KCC2G_HUMAN (225-505): 1.35e-49: 182: 22.92
+	Hs
		1038874 CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00		KCC2B_HUMAN (267-505): 2.71e-45: 171: 25.31