HitPredict

Interactor 1: SRBP2 (Q12772)
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
Gene: SREBF2

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37788672
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1141 Hs			1 768
+	Hs
		615382 SON_HUMAN (1-530): 4.28e-31: 135: 10.20		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1113894 CBP_HUMAN (5-493): 1.72e-27: 123: 12.45		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		130460 SPT5H_HUMAN (2-315): 9.29e-28: 123: 11.88		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		323871 SC31A_HUMAN (2-398): 1.35e-24: 113: 9.70		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1113742 KMT2C_HUMAN (11-533): 2.98e-13: 76.9: 8.68		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		624252 TFE3_HUMAN (37-467): 2.51e-25: 114: 18.68		CUL2_HUMAN (30-768): 0: 673: 26.17