Protein: TFE3
Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33)

Gene: TFE3
Organism: Homo sapiens
Interactions: 79
UniProt ID: P19532

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

623614

TFEB
Transcription factor EB

4

13

Small-scale

0.903

High

269091

MITF
Microphthalmia-associated transcription factor

4

13

Small-scale

0.895

High

168934

TFEC
Transcription factor EC

1

13

Small-scale

0.647

High

624215

TFE3
Transcription factor E3

1

15

Small-scale

0.647

High

624221

1433T
14-3-3 protein theta

3

20

High-throughput

0.643

High

224938

TLX3
T-cell leukemia homeobox protein 3

1

12

High-throughput

0.618

High

624260

RRAGA
Ras-related GTP-binding protein A

1

9

Small-scale

0.618

High

624268

RRAGC
Ras-related GTP-binding protein C

1

9

Small-scale

0.618

High

624269

VSX1
Visual system homeobox 1

1

4

High-throughput

0.618

High

624270

LTOR3
Ragulator complex protein LAMTOR3

2

1

High-throughput

0.606

High

624241

SMAD3
Mothers against decapentaplegic homolog 3

2

4

Small-scale

0.602

High

624251

SMAD4
Mothers against decapentaplegic homolog 4

2

4

Small-scale

0.602

High

624236

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

624249

TIF1B
Transcription intermediary factor 1-beta

2

6

Small-scale

0.601

High

143392

E2F3
Transcription factor E2F3

1

3

Small-scale

0.573

High

624271

FBW1B
F-box/WD repeat-containing protein 11

1

14

Small-scale

0.561

High

624253

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

624273

FBW1A
F-box/WD repeat-containing protein 1A

1

14

Small-scale

0.527

High

460429

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.515

High

580381

ALDR
Aldo-keto reductase family 1 member B1

1

1

High-throughput

0.515

High

624220

SYVC
Valine--tRNA ligase

1

2

High-throughput

0.515

High

624225

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.515

High

624230

ACLY
ATP-citrate synthase

1

3

High-throughput

0.515

High

624240

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.515

High

624242

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.515

High

624252

CUL2
Cullin-2

1

4

High-throughput

0.515

High

624255

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

4

High-throughput

0.515

High

624257

NEDD8
Ubiquitin-like protein NEDD8

1

2

High-throughput

0.515

High

624265

PHB2
Prohibitin-2

1

1

High-throughput

0.515

High

166118

AIM2
Interferon-inducible protein AIM2

1

0

High-throughput

0.513

High

624262

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

8

Small-scale

0.501

High

176645

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.493

High

142827

NFIB
Nuclear factor 1 B-type

1

6

High-throughput

0.479

High

172463

XPO1
Exportin-1

1

8

High-throughput

0.479

High

189104

IPO8
Importin-8

1

1

Small-scale

0.479

High

194507

KDM6A
Lysine-specific demethylase 6A

1

3

Small-scale

0.479

High

291209

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

333933

SMC2
Structural maintenance of chromosomes protein 2

1

3

High-throughput

0.479

High

339650

KLF8
Krueppel-like factor 8

1

17

High-throughput

0.479

High

403808

GCR
Glucocorticoid receptor

1

11

High-throughput

0.479

High

473780

NFIC
Nuclear factor 1 C-type

1

12

High-throughput

0.479

High

624216

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

624217

GSTM3
Glutathione S-transferase Mu 3

1

1

High-throughput

0.479

High

624218

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.479

High

624219

PSA3
Proteasome subunit alpha type-3

1

1

High-throughput

0.479

High

624226

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

624227

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.479

High

624228

NASP
Nuclear autoantigenic sperm protein

1

2

High-throughput

0.479

High

624231

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

624232

NP1L1
Nucleosome assembly protein 1-like 1

1

5

High-throughput

0.479

High

624233

SYMC
Methionine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

624234

KLF3
Krueppel-like factor 3

1

16

High-throughput

0.479

High

624235

PSA6
Proteasome subunit alpha type-6

1

1

High-throughput

0.479

High

624237

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

8

High-throughput

0.479

High

624238

H4
Histone H4

1

13

High-throughput

0.479

High

624239

SUMO1
Small ubiquitin-related modifier 1

1

4

Small-scale

0.479

High

624243

SET
Protein SET

1

5

High-throughput

0.479

High

624244

EWS
RNA-binding protein EWS

1

10

High-throughput

0.479

High

624245

IRF8
Interferon regulatory factor 8

1

1

High-throughput

0.479

High

624246

DHX9
ATP-dependent RNA helicase A

1

7

High-throughput

0.479

High

624247

NFIA
Nuclear factor 1 A-type

1

10

High-throughput

0.479

High

624248

TADBP
TAR DNA-binding protein 43

1

11

Small-scale

0.479

High

624250

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

11

High-throughput

0.479

High

624254

KLF5
Krueppel-like factor 5

1

18

High-throughput

0.479

High

624261

PDC6I
Programmed cell death 6-interacting protein

1

14

High-throughput

0.479

High

624263

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

4

High-throughput

0.479

High

624266

KLF16
Krueppel-like factor 16

1

16

High-throughput

0.479

High

624267

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

624272

HDAC5
Histone deacetylase 5

1

13

Small-scale

0.479

High

624274

KLF12
Krueppel-like factor 12

1

15

High-throughput

0.479

High

624229

SPSY
Spermine synthase

1

0

High-throughput

0.458

High

624258

FSCN1
Fascin

1

0

High-throughput

0.458

High

624264

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.458

High

624223

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

624224

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

624259

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.445

High

624222

ECHM
Enoyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.249

Low

624256

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025