HitPredict

Interactor 1: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	35271311, 24526689
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 129 Hs			1 126
+	Hs
		617950 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		1087075 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		617974 H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		1087239 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1087377 H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1216239 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		918497 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707681 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		886117 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		1087366 H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1274408 H2A1H_HUMAN (1-127): 1.77e-65: 196: 96.06		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		883049 H2A1H_HUMAN (1-127): 1.77e-65: 196: 96.06		H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83
+	Hs
		886151 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		886186 H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		241623 H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		1087049 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1216224 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1087076 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		1216241 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		1150515 H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06		H2B2C_HUMAN (1-96): 1.25e-43: 143: 91.67