Protein: INSY1
Inhibitory synaptic factor 1 (InSyn1)

Gene: INSY1, INSYN1
Organism: Homo sapiens
Interactions: 169
UniProt ID: Q2T9L4

Gene Ontology (top 5):
GO:0014069 - postsynaptic density
GO:0060080 - inhibitory postsynaptic potential
GO:0098982 - GABA-ergic synapse
GO:0099084 - postsynaptic specialization organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

262390

DTNB
Dystrobrevin beta

3

3

High-throughput

0.665

High

1179812

CC146
Coiled-coil domain-containing protein 146

2

1

High-throughput

0.553

High

1179871

ABI2
Abl interactor 2

2

1

High-throughput

0.553

High

786636

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

2

Small-scale

0.543

High

244161

KIF5C
Kinesin heavy chain isoform 5C

1

4

High-throughput

0.536

High

1179808

HOME1
Homer protein homolog 1

1

3

High-throughput

0.536

High

1179815

MINK1
Misshapen-like kinase 1

1

2

High-throughput

0.536

High

1179867

HOME2
Homer protein homolog 2

1

3

High-throughput

0.536

High

1179805

ARC
Activity-regulated cytoskeleton-associated protein

1

0

High-throughput

0.513

High

1179882

MKLN1
Muskelin

1

0

High-throughput

0.513

High

161614

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

1

High-throughput

0.489

High

168858

PLD2
Phospholipase D2

1

1

High-throughput

0.489

High

212666

DAPK3
Death-associated protein kinase 3

1

1

High-throughput

0.489

High

272674

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

1

High-throughput

0.489

High

278364

NCOR1
Nuclear receptor corepressor 1

1

1

High-throughput

0.489

High

323728

AP2A2
AP-2 complex subunit alpha-2

1

2

High-throughput

0.489

High

331018

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.489

High

340146

PCNT
Pericentrin

1

1

High-throughput

0.489

High

344704

AP2A1
AP-2 complex subunit alpha-1

1

2

High-throughput

0.489

High

348134

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

2

High-throughput

0.489

High

429985

JUN
Transcription factor Jun

1

4

High-throughput

0.489

High

547453

DMD
Dystrophin

1

3

High-throughput

0.489

High

583567

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

3

High-throughput

0.489

High

605260

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

3

High-throughput

0.489

High

724392

COR1A
Coronin-1A

1

2

High-throughput

0.489

High

749923

KINH
Kinesin-1 heavy chain

1

4

High-throughput

0.489

High

839772

EPS15
Epidermal growth factor receptor substrate 15

1

1

High-throughput

0.489

High

862656

UTRN
Utrophin

1

3

High-throughput

0.489

High

913504

KIF11
Kinesin-like protein KIF11

1

4

High-throughput

0.489

High

921342

CEBPG
CCAAT/enhancer-binding protein gamma

1

4

High-throughput

0.489

High

922581

AP2S1
AP-2 complex subunit sigma

1

1

High-throughput

0.489

High

1039742

CREB5
Cyclic AMP-responsive element-binding protein 5

1

3

High-throughput

0.489

High

1083244

AP1B1
AP-1 complex subunit beta-1

1

2

High-throughput

0.489

High

1087007

KIF5A
Kinesin heavy chain isoform 5A

1

4

High-throughput

0.489

High

1103757

PLD1
Phospholipase D1

1

1

High-throughput

0.489

High

1104791

SNTA1
Alpha-1-syntrophin

1

3

High-throughput

0.489

High

1104830

SNTB2
Beta-2-syntrophin

1

3

High-throughput

0.489

High

1118435

SNTB1
Beta-1-syntrophin

1

3

High-throughput

0.489

High

1144819

RABE1
Rab GTPase-binding effector protein 1

1

1

High-throughput

0.489

High

1157447

PKN1
Serine/threonine-protein kinase N1

1

2

High-throughput

0.489

High

1157516

PKN2
Serine/threonine-protein kinase N2

1

2

High-throughput

0.489

High

1179783

EMAL3
Echinoderm microtubule-associated protein-like 3

1

3

High-throughput

0.489

High

1179784

EIPR1
EARP and GARP complex-interacting protein 1

1

2

High-throughput

0.489

High

1179788

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.489

High

1179792

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

1

High-throughput

0.489

High

1179799

PKN3
Serine/threonine-protein kinase N3

1

2

High-throughput

0.489

High

1179804

MAEA
E3 ubiquitin-protein transferase MAEA

1

1

High-throughput

0.489

High

1179820

POC1A
POC1 centriolar protein homolog A

1

1

High-throughput

0.489

High

1179821

POC1B
POC1 centriolar protein homolog B

1

1

High-throughput

0.489

High

1179843

KIF2C
Kinesin-like protein KIF2C

1

3

High-throughput

0.489

High

1179844

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

1

High-throughput

0.489

High

1179847

NADAP
Kanadaptin

1

2

High-throughput

0.489

High

1179850

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

1

High-throughput

0.489

High

1179852

KLC2
Kinesin light chain 2

1

1

High-throughput

0.489

High

1179856

RABE2
Rab GTPase-binding effector protein 2

1

1

High-throughput

0.489

High

1179859

WDR26
WD repeat-containing protein 26

1

2

High-throughput

0.489

High

1179860

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

1

High-throughput

0.489

High

1179863

EMAL4
Echinoderm microtubule-associated protein-like 4

1

1

High-throughput

0.489

High

1179868

KLC4
Kinesin light chain 4

1

1

High-throughput

0.489

High

1179870

NDE1
Nuclear distribution protein nudE homolog 1

1

1

High-throughput

0.489

High

1179873

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

2

High-throughput

0.489

High

1179880

TNIK
TRAF2 and NCK-interacting protein kinase

1

2

High-throughput

0.489

High

1179886

KIF3A
Kinesin-like protein KIF3A

1

4

High-throughput

0.489

High

1179887

C170B
Centrosomal protein of 170 kDa protein B

1

1

High-throughput

0.489

High

1179888

DTNA
Dystrobrevin alpha

1

3

High-throughput

0.489

High

1179890

NCOR2
Nuclear receptor corepressor 2

1

2

High-throughput

0.489

High

1179891

COMDA
COMM domain-containing protein 10

1

4

High-throughput

0.489

High

1179830

Q96AL5
PBX3 protein

1

1

High-throughput

0.470

High

823945

PBX3
Pre-B-cell leukemia transcription factor 3

1

1

High-throughput

0.439

High

90708

WASH3
Putative WAS protein family homolog 3

1

1

High-throughput

0.407

High

1179865

WASH6
WAS protein family homolog 6

1

1

High-throughput

0.407

High

333344

SNAPN
SNARE-associated protein Snapin

3

0

High-throughput

0.346

High

1179835

MCRS1
Microspherule protein 1

3

0

High-throughput

0.346

High

1179836

BORC6
BLOC-1-related complex subunit 6

3

0

High-throughput

0.346

High

1179885

WASC3
WASH complex subunit 3

3

0

High-throughput

0.346

High

1179881

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

2

0

High-throughput

0.320

High

952194

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

0

High-throughput

0.316

High

1179876

CS025
UPF0449 protein C19orf25

2

0

High-throughput

0.316

High

66615

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

85267

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.279

Low

187357

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.279

Low

188297

HDAC3
Histone deacetylase 3

1

0

High-throughput

0.279

Low

217098

MS18B
Protein Mis18-beta

1

0

High-throughput

0.279

Low

244706

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.279

Low

252869

EXOC3
Exocyst complex component 3

1

0

High-throughput

0.279

Low

253506

ANM3
Protein arginine N-methyltransferase 3

1

0

High-throughput

0.279

Low

257122

CCD22
Coiled-coil domain-containing protein 22

1

0

High-throughput

0.279

Low

276313

HMMR
Hyaluronan mediated motility receptor

1

0

High-throughput

0.279

Low

298179

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

503590

TFPT
TCF3 fusion partner

1

0

High-throughput

0.279

Low

687815

SYVC
Valine--tRNA ligase

1

0

High-throughput

0.279

Low

913136

STAT2
Signal transducer and activator of transcription 2

1

0

High-throughput

0.279

Low

1055222

MTG8
Protein CBFA2T1

1

0

High-throughput

0.279

Low

1063127

GOGA3
Golgin subfamily A member 3

1

0

High-throughput

0.279

Low

1086363

AKP13
A-kinase anchor protein 13

1

0

High-throughput

0.279

Low

1110788

PKD2
Polycystin-2

1

0

High-throughput

0.279

Low

1131871

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

1132734

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.279

Low

1150911

TRIPB
Thyroid receptor-interacting protein 11

1

0

High-throughput

0.279

Low

1179785

CCD93
Coiled-coil domain-containing protein 93

1

0

High-throughput

0.279

Low

1179786

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.279

Low

1179787

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.279

Low

1179789

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.279

Low

1179790

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.279

Low

1179791

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.279

Low

1179793

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.279

Low

1179794

FTM
Protein fantom

1

0

High-throughput

0.279

Low

1179795

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.279

Low

1179796

PHLB3
Pleckstrin homology-like domain family B member 3

1

0

High-throughput

0.279

Low

1179797

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.279

Low

1179798

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.279

Low

1179800

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

0

High-throughput

0.279

Low

1179801

SAS6
Spindle assembly abnormal protein 6 homolog

1

0

High-throughput

0.279

Low

1179802

CA122
Uncharacterized protein C1orf122

1

0

High-throughput

0.279

Low

1179803

RUFY3
Protein RUFY3

1

0

High-throughput

0.279

Low

1179806

COMD7
COMM domain-containing protein 7

1

0

High-throughput

0.279

Low

1179807

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.279

Low

1179809

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

0

High-throughput

0.279

Low

1179810

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.279

Low

1179811

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.279

Low

1179813

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

0

High-throughput

0.279

Low

1179814

NIN
Ninein

1

0

High-throughput

0.279

Low

1179816

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.279

Low

1179817

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.279

Low

1179818

BANP
Protein BANP

1

0

High-throughput

0.279

Low

1179819

SCAI
Protein SCAI

1

0

High-throughput

0.279

Low

1179822

DEN10
DENN domain-containing protein 10

1

0

High-throughput

0.279

Low

1179823

NEK9
Serine/threonine-protein kinase Nek9

1

0

High-throughput

0.279

Low

1179825

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.279

Low

1179826

IFT81
Intraflagellar transport protein 81 homolog

1

0

High-throughput

0.279

Low

1179827

BORC5
BLOC-1-related complex subunit 5

1

0

High-throughput

0.279

Low

1179828

SLAF9
SLAM family member 9

1

0

High-throughput

0.279

Low

1179829

EXOC4
Exocyst complex component 4

1

0

High-throughput

0.279

Low

1179831

BORC7
BLOC-1-related complex subunit 7

1

0

High-throughput

0.279

Low

1179832

SKA1
SKA complex subunit 1

1

0

High-throughput

0.279

Low

1179833

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.279

Low

1179834

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.279

Low

1179837

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.279

Low

1179838

REXO5
RNA exonuclease 5

1

0

High-throughput

0.279

Low

1179839

VPS50
Syndetin

1

0

High-throughput

0.279

Low

1179840

IFT74
Intraflagellar transport protein 74 homolog

1

0

High-throughput

0.279

Low

1179841

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

High-throughput

0.279

Low

1179842

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.279

Low

1179845

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.279

Low

1179846

BBLN
Bublin coiled-coil protein

1

0

High-throughput

0.279

Low

1179848

OSBL1
Oxysterol-binding protein-related protein 1

1

0

High-throughput

0.279

Low

1179849

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.279

Low

1179851

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.279

Low

1179853

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.279

Low

1179854

TARA
TRIO and F-actin-binding protein

1

0

High-throughput

0.279

Low

1179855

CENPH
Centromere protein H

1

0

High-throughput

0.279

Low

1179857

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.279

Low

1179858

CS044
Uncharacterized protein C19orf44

1

0

High-throughput

0.279

Low

1179861

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.279

Low

1179862

KANL2
KAT8 regulatory NSL complex subunit 2

1

0

High-throughput

0.279

Low

1179864

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

1179866

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

0

High-throughput

0.279

Low

1179869

COMD8
COMM domain-containing protein 8

1

0

High-throughput

0.279

Low

1179872

COMD9
COMM domain-containing protein 9

1

0

High-throughput

0.279

Low

1179874

COMD3
COMM domain-containing protein 3

1

0

High-throughput

0.279

Low

1179875

CTNL1
Alpha-catulin

1

0

High-throughput

0.279

Low

1179877

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.279

Low

1179878

TSYL4
Testis-specific Y-encoded-like protein 4

1

0

High-throughput

0.279

Low

1179879

RABX5
Rab5 GDP/GTP exchange factor

1

0

High-throughput

0.279

Low

1179883

ODF2L
Protein BCAP

1

0

High-throughput

0.279

Low

1179884

EXOC7
Exocyst complex component 7

1

0

High-throughput

0.279

Low

1179889

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

0

High-throughput

0.279

Low

521717

H14
Histone H1.4

1

0

High-throughput

0.269

Low

1179824

MIPT3
TRAF3-interacting protein 1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025