HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.985

The method score is based on:

Property Details
Experiments 19465477, 29715546, 35271311, 23575225, 22193716, 37101169, 20020773, 26099433, 19383787, 21666678, 26735904, 29531287, 31235914, 23384725
Identification Methods pull down, affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, transmission electron microscopy, molecular sieving, classical fluorescence spectroscopy, atomic force microscopy, nuclear magnetic resonance, 3D electron microscopy and 4 others

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Interaction Type direct interaction, physical association, disulfide bond

The annotation score is based on:

Property Details
Interacting Pfam domains RRM_1~RRM_1, TDP-43_C~TDP-43_C, TDP43_N~TDP43_N
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001933 - negative regulation of protein phosphorylation
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
and 30 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 414
Hs

1 414
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+ Ce
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Last updated: 11Aug2025