HitPredict

Interactor 1: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Interactor 2: IQGA1 (Q9JKF1)
Ras GTPase-activating-like protein IQGAP1
Gene: Iqgap1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28706196
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005096 - GTPase activator activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0044877 - protein-containing complex binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1186 Mm			1 1657
+	Mm
		1112565 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		IQGA2_MOUSE (242-1657): 0: 1420: 52.60
+	Hs
		809252 RAP1A_HUMAN (398-567): 1.81e-70: 235: 23.03		IQGA1_HUMAN (1-1657): 0: 1837: 95.96
+	Mm
		1112542 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DAB2P_MOUSE (871-1481): 6.31e-113: 389: 12.40
+	Mm
		1012208 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		Q0VAV5_MOUSE (877-1450): 1.09e-99: 352: 12.50
+	Mm
		93233 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		E9PW37_MOUSE (877-1450): 1.35e-99: 352: 12.50
+	Mm
		99969 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		SYGP1_MOUSE (877-1477): 1.46e-87: 316: 13.56
+	Mm
		99872 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		F6QQP6_MOUSE (1003-1481): 1.01e-85: 299: 13.32
+	Mm
		980214 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		NF1_MOUSE (1002-1317): 1.94e-57: 222: 21.89
+	Mm
		1112670 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		RASL1_MOUSE (970-1280): 8.65e-59: 220: 19.08
+	Mm
		93411 E9Q3K3_MOUSE (80-1145): 0: 783: 43.63		SYGP1_MOUSE (877-1477): 1.46e-87: 316: 13.56
+	Hs
		1355995 AGAP1_HUMAN (384-1145): 0: 713: 53.70		NGAP_HUMAN (877-1428): 2.12e-97: 343: 12.81
+	Mm
		100045 AGAP1_MOUSE (384-1145): 0: 710: 53.70		SYGP1_MOUSE (877-1477): 1.46e-87: 316: 13.56
+	Mm
		99881 F8VQE9_MOUSE (384-1150): 0: 660: 51.54		SYGP1_MOUSE (877-1477): 1.46e-87: 316: 13.56
+	Hs
		598546 AGAP1_HUMAN (384-1145): 0: 713: 53.70		NF1_HUMAN (1002-1317): 1.93e-57: 222: 21.60
+	Mm
		100015 ASAP2_MOUSE (690-1168): 1.01e-99: 341: 21.08		SYGP1_MOUSE (877-1477): 1.46e-87: 316: 13.56
+	Mm
		88329 D3YX85_MOUSE (690-1168): 1.11e-97: 335: 21.08		SYGP1_MOUSE (877-1477): 1.46e-87: 316: 13.56
+	Mm
		100001 GIT1_MOUSE (932-1139): 6.25e-72: 258: 32.88		SYGP1_MOUSE (877-1477): 1.46e-87: 316: 13.56
+	Sc
		533758 RSR1_YEAST (398-656): 8.23e-79: 262: 17.91		BUD2_YEAST (765-1313): 2.14e-80: 291: 16.47
+	Hs
		596403 ACAP2_HUMAN (634-1166): 2.28e-51: 197: 13.44		RASA1_HUMAN (1025-1322): 1.13e-18: 94.9: 17.11