HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBX44 (Q9H4M3)
F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3)
Gene: FBXO44

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	26186194, 25970626, 28514442, 33961781, 17215248, 18203720, 21640084, 29103612, 37028429, 37837399, 21145461
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 255
+	Hs
		1112731 CUL1_HUMAN (1-776): 0: 909: 100.00		FBX6_HUMAN (2-254): 3.07e-140: 397: 75.10
+	Hs
		1112774 CUL1_HUMAN (1-776): 0: 909: 100.00		FBX2_HUMAN (16-252): 2.81e-115: 333: 48.33
+	Mm
		1282066 CUL1_MOUSE (1-776): 0: 911: 99.87		FBX2_MOUSE (16-252): 3.58e-112: 326: 48.95
+	Hs
		1112651 CUL1_HUMAN (1-776): 0: 909: 100.00		FBX17_HUMAN (6-254): 1.78e-109: 318: 33.71
+	Hs
		1112610 CUL1_HUMAN (1-776): 0: 909: 100.00		FBX27_HUMAN (19-254): 1.27e-105: 308: 39.36
+	Hs
		1115059 CUL4A_HUMAN (7-776): 0: 778: 30.41		FBX44_HUMAN (1-255): 3.63e-141: 397: 100.00
+	Hs
		1115429 CUL4B_HUMAN (7-776): 0: 771: 29.90		FBX44_HUMAN (1-255): 3.63e-141: 397: 100.00
+	Hs
		1371829 CUL5_HUMAN (2-776): 0: 620: 28.85		FBX17_HUMAN (6-254): 1.78e-109: 318: 33.71